parietal cortex
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- MeSH
- čelní lalok MeSH
- corpus callosum MeSH
- histologie MeSH
- kočky MeSH
- temenní lalok MeSH
- Check Tag
- kočky MeSH
A current topic in neurobiology is the study of the role of various brain structures in processing of spatial information. The present study was aimed at elucidating the role of the rat posterior parietal cortex in performing a place avoidance task. Two variants of the task were used: an arena frame task, in which animals were trained to avoid a sector defined by local cues bound to the surface of a rotating arena, and the room frame task, in which the shock sector was defined with respect to distal room landmarks. The results showed that both control and lesioned rats were able to efficiently solve both tasks, while locomotion was not altered. These results suggest that the posterior parietal cortex is not crucial for the processing of either proximal or distal cues in place avoidance.
- MeSH
- analýza rozptylu MeSH
- časové faktory MeSH
- chování zvířat MeSH
- financování organizované MeSH
- krysa rodu rattus MeSH
- lokomoce fyziologie MeSH
- orientace MeSH
- podněty MeSH
- potkani Long-Evans MeSH
- prostorové chování fyziologie MeSH
- reakční čas fyziologie MeSH
- temenní lalok fyziologie zranění MeSH
- učení vyhýbat se fyziologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- MeSH
- čelní lalok MeSH
- corpus callosum MeSH
- histologie MeSH
- kočky MeSH
- temenní lalok MeSH
- Check Tag
- kočky MeSH
- MeSH
- biomedicínský výzkum MeSH
- evokované potenciály MeSH
- lidé MeSH
- mozková kůra MeSH
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- lidé MeSH
In post-stroke spasticity (PSS), effective treatment with botulinum neurotoxin (BoNT) is associated with transient decrease in activation of the ipsilesional superior parietal lobule (SPL) and intraparietal sulcus (IPS). We hypothesized that this would be reflected in changes in resting-state functional connectivity (rsFC) of the SPL/IPS. Our aim was therefore to assess rsFC of the ipsilesional SPL/IPS in chronic stroke patients with hemiparesis both with and without PSS and to explore the relationship between SPL/IPS rsFC and PSS severity. To this end, fourteen chronic stroke patients with upper limb weakness and PSS (the PSS group) and 8 patients with comparable weakness but no PSS (the control group) underwent clinical evaluation and 3 fMRI examinations, at baseline (W0) and 4 and 11 weeks after BoNT (W4 and W11, respectively). Seed-based rsFC of the atlas-based SPL and IPS was evaluated using a group×time interaction analysis and a correlation analysis with PSS severity (modified Ashworth scale), integrity of the ipsilesional somatosensory afferent pathway (evoked potential N20 latency), and age. In the PSS group, transient improvement in PSS was associated with increase in rsFC between the ipsilesional IPS and the contralesional SPL at W4. The interhemispheric connectivity was negatively correlated with PSS severity at baseline and with PSS improvement at W4. We propose adaptation of the internal forward model as the putative underlying mechanism and discuss its possible association with increased limb use, diminished spastic dystonia, or improved motor performance, as well as its potential contribution to the clinical effects of BoNT.
- MeSH
- botulotoxiny typu A * terapeutické užití MeSH
- cévní mozková příhoda * komplikace MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- nervosvalové látky * terapeutické užití MeSH
- svalová spasticita MeSH
- temenní lalok MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
