Hyperinflation is the consequence of a dysbalance of static forces (determining the relaxation volume) and/or of the dynamic components. The relaxation volume is determined by an equilibrium between the elastic recoil of the lungs and of the chest walls. The dynamic components include the pattern of breathing, upper airway resistance and postinspiratory activity of inspiratory muscles. The respiratory and laryngeal muscles are under control and thus both static and dynamic hyperinflation can be secured. Our knowledge of the mechanism of increased FRC is based on clinical observations and on experiments. The most frequent stimuli leading to a dynamic increase of functional residual lung capacity (FRC) include hypoxia and vagus afferentation. Regulation of FRC is still and undetermined concept. The controlled increase of FRC, hyperinflation, participates in a number of lung diseases.

• MeSH
• funkční reziduální kapacita * MeSH
• lidé MeSH
• mechanika dýchání fyziologie   MeSH
• plíce fyziologie   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

The aim of this study was to systematically analyze the potential and limitations of using plant functional trait observations from global databases versus in situ data to improve our understanding of vegetation impacts on ecosystem functional properties (EFPs). Using ecosystem photosynthetic capacity as an example, we first provide an objective approach to derive robust EFP estimates from gross primary productivity (GPP) obtained from eddy covariance flux measurements. Second, we investigate the impact of synchronizing EFPs and plant functional traits in time and space to evaluate their relationships, and the extent to which we can benefit from global plant trait databases to explain the variability of ecosystem photosynthetic capacity. Finally, we identify a set of plant functional traits controlling ecosystem photosynthetic capacity at selected sites. Suitable estimates of the ecosystem photosynthetic capacity can be derived from light response curve of GPP responding to radiation (photosynthetically active radiation or absorbed photosynthetically active radiation). Although the effect of climate is minimized in these calculations, the estimates indicate substantial interannual variation of the photosynthetic capacity, even after removing site-years with confounding factors like disturbance such as fire events. The relationships between foliar nitrogen concentration and ecosystem photosynthetic capacity are tighter when both of the measurements are synchronized in space and time. When using multiple plant traits simultaneously as predictors for ecosystem photosynthetic capacity variation, the combination of leaf carbon to nitrogen ratio with leaf phosphorus content explains the variance of ecosystem photosynthetic capacity best (adjusted R2 = 0.55). Overall, this study provides an objective approach to identify links between leaf level traits and canopy level processes and highlights the relevance of the dynamic nature of ecosystems. Synchronizing measurements of eddy covariance fluxes and plant traits in time and space is shown to be highly relevant to better understand the importance of intra- and interspecific trait variation on ecosystem functioning.

• Klíčová slova
• FLUXNET, TRY database, ecosystem functional property, eddy covariance, interannual variability, photosynthetic capacity, plant traits, spatiotemporal variability,
• Publikační typ
• časopisecké články MeSH

Functional residual capacity of the lungs (FRC) was measured by a plethysmographic method in anaesthetized, intubated rats breathing air or a hypoxic mixture (10% O2 in N2), before and after bilateral cervical vagotomy. Inhalation of the with intact vagi, the drop in Pao2 was accompanied by a significant rise of FRC; after hypoxic mixture led to the same decrease in Pao2 before and after vagotomy. In rats vagotomy, hypoxia did not affect the FRC. The vagal nerves are thus apparently necessary for the increase of FRC during hypoxia in the rat.

• MeSH
• akutní nemoc MeSH
• funkční reziduální kapacita * MeSH
• hypoxie patofyziologie   MeSH
• inbrední kmeny potkanů MeSH
• krysa rodu Rattus MeSH
• měření objemu plic * MeSH
• nervus vagus patofyziologie   MeSH
• plicní ventilace MeSH
• vagotomie MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

Experimental pneumonia induced by intratracheal application of carrageenan or paraquat increases the functional residual lung capacity (FRC) in rats. The mechanism of this increase is not clear, but a decrease in PO(2) may be involved. To test this possibility, we attempted to eliminate the PO(2) decrease in carrageenan-treated rats by exposing them to hyperoxia. Animals of the first group were exposed to 7 days of hyperoxia (F(I)O(2) 0.78-0.84, group Car+O(2)) after intratracheal application of carrageenan (0.5 ml of 0.7 % carrageenan in saline), whereas animals of the second group were given the same dose of carrageenan but breathed air (group Car+A). The third group of rats was kept for seven days in hyperoxia (group O(2)) and the fourth group served as controls (C). The animals were then anesthetized and intubated and their ventilatory parameters and FRC were measured during air breathing. Carrageenan application induced a FRC increase (Car+A 2.0+/-0.2 ml, C 1.6+/-0.1 ml), which was not seen in carrageenan-treated rats exposed to hyperoxia (Car+O(2) 1.6+/-0.1 ml). Hyperoxia alone did not affect the value of FRC (O(2) 1.5+/-0.1 ml). These results support the hypothesis that a decrease in PO(2) plays an important role in the carrageenan-induced increase of FRC in rats.

• MeSH
• aspirační pneumonie chemicky indukované   patofyziologie   MeSH
• dechový objem účinky léků   fyziologie   MeSH
• funkční reziduální kapacita účinky léků   fyziologie   MeSH
• hyperoxie patofyziologie   MeSH
• karagenan farmakologie   MeSH
• krysa rodu Rattus MeSH
• kyslík farmakologie   MeSH
• mechanika dýchání účinky léků   fyziologie   MeSH
• měření objemu plic MeSH
• plíce účinky léků   patofyziologie   MeSH
• plicní ventilace účinky léků   fyziologie   MeSH
• potkani Wistar MeSH
• tělesná hmotnost fyziologie   MeSH
• vydechnutí účinky léků   fyziologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• karagenan MeSH
• kyslík MeSH

To determine whether changes in partial pressure of CO2 participate in mechanism enlarging the lung functional residual capacity (FRC) during chronic hypoxia, we measured FRC and ventilation in rats exposed either to poikilocapnic (group H, F(I)O2 0.1, F(I)CO2 <0.01) or hypercapnic (group H+CO2, F(I)O2 0.1, F(I)CO2 0.04-0.05) hypoxia for the three weeks and in the controls (group C) breathing air. At the end of exposure a body plethysmograph was used to measure ventilatory parameters (V'(E), f(R), V(T)) and FRC during air breathing and acute hypoxia (10 % O2 in N2). The exposure to hypoxia for three weeks increased FRC measured during air breathing in both experimental groups (H: 3.0+/-0.1 ml, H+CO2: 3.1+/-0.2 ml, C: 1.8+/-0.2 ml). During the following acute hypoxia, we observed a significant increase of FRC in the controls (3.2+/-0.2 ml) and in both experimental groups (H: 3.5+/-0.2 ml, H+CO2: 3.6+/-0.2 ml). Because chronic hypoxia combined with chronic hypercapnia and chronic poikilocapnic hypoxia induced the same increase of FRC, we conclude that hypercapnia did not participate in the FRC enlargement during chronic hypoxia.

• MeSH
• chronická nemoc MeSH
• funkční reziduální kapacita * MeSH
• hyperkapnie diagnóza   patofyziologie   MeSH
• hypoxie diagnóza   patofyziologie   MeSH
• krysa rodu Rattus MeSH
• mechanika dýchání MeSH
• oxid uhličitý krev   MeSH
• potkani Wistar MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• oxid uhličitý MeSH

BACKGROUND: Although evidence suggests that functional endurance capacity is the most important component associated with future health, little is known of how it is associated with multiple other physical fitness components. Since various physical fitness aspects do not change the same as functional endurance capacity during childhood, it is necessary to establish possible associations between functional endurance capacity and other physical fitness components in children. Therefore, the main purpose of the study was to test the associations between functional endurance capacity with other physical fitness components in 7-14-year-old children, stratified by gender. METHODS: In this cross-sectional study, we recruited 1612 children [mean age ± standard deviation (SD) = 9.72 ± 2.37 years; 52.5% girls). Health-related physical fitness components included: 1) body-mass index (kg/m2) calculated from height and weight (measure of body size), 2) sit-and-reach test (measure of flexibility), 3) standing broad jump (measure of explosive strength of lower extremities), 4) sit-ups in 30 s (measure of repetitive strength of the trunk), 5) 10 × 5 shuttle run test (measure of agility) and 6) 20-m shuttle run test (measure of functional endurance capacity). The associations were performed using generalized estimating equations with beta (β) coefficients. RESULTS: After adjusting for age, functional endurance capacity was associated with sit-and-reach test (β = 0.13, p < 0.001), standing broad jump (β = 0.59, p < 0.001), sit-ups in 30 s (β = 0.53, p < 0.001) and 10 × 5 shuttle run test (β = - 0.56, p < 0.001) in boys. In girls, functional endurance capacity was associated with body-mass index (β = - 0.12, p < 0.001), sit-and-reach test (β = 0.21, p < 0.001), standing broad jump (β = 0.25, p < 0.001), sit-ups in 30 s (β = 0.36, p < 0.001) and 10 × 5 shuttle run test (β = - 0.40, p < 0.001). No significant associations between functional endurance capacity and body-mass index in boys were observed. CONCLUSIONS: Although significant, functional endurance capacity is weakly to moderately associated with other physical fitness components, pointing out that such measure should be tested separately from other aspects of physical fitness in school-aged children.

• Klíčová slova
• Functional endurance capacity, Musculoskeletal fitness, School-aged children, Testing,
• MeSH
• cvičení * MeSH
• dítě MeSH
• index tělesné hmotnosti MeSH
• lidé MeSH
• mladiství MeSH
• průřezové studie MeSH
• tělesná hmotnost MeSH
• tělesná výkonnost * MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

BACKGROUND: The chronic course of schizophrenia typically results in severe social, vocational and functional impairment, interferes with patients' autonomy, reduces quality of life and increases disability. AIMS: The aim of our study was: (1) to assess social and functional impairment in schizophrenia outpatients from the Czech Republic and Slovakia; and (2) to examine a relationship between functioning and antipsychotic treatment and demographic variables. METHODS: Schizophrenia outpatients in a stable phase of illness, treated with current antipsychotic medication for a minimum of one month, were enrolled for the study. Demographic and medication data were recorded. The Personal and Social Performance (PSP), Subjective Well-Being under Neuroleptics (SWN) and Clinical Global Impressions (CGI) scales were administered. RESULTS: The total number of study subjects was 926. Most PSP values were within the interval of moderate impairment. Functional performance correlated positively with subjective satisfaction with medication and negatively with symptom severity. Higher education predicted better functioning on PSP. The best performance was associated with a stable relationship and a useful work role. Patients who showed the best level of functioning were more likely to be treated with antipsychotic monotherapy. No difference among drugs in monotherapy was found in subjective satisfaction. CONCLUSIONS: The PSP values of stable schizophrenia outpatients indicated a moderate degree of impairment. Improvement of functional capacity remains one of the unmet needs of schizophrenia patients.

• Klíčová slova
• Schizophrenia, antipsychotic drugs, functional outcome, patient outcome assessment, well-being,
• MeSH
• antipsychotika terapeutické užití   MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• osobní uspokojení MeSH
• posuzování pracovní neschopnosti * MeSH
• průřezové studie MeSH
• schizofrenie (psychologie) * MeSH
• schizofrenie farmakoterapie   patofyziologie   MeSH
• stupeň závažnosti nemoci MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Slovenská republika MeSH
• Názvy látek
• antipsychotika MeSH

In 28 patients with cystic fibrosis aged 5--24 years the values of maximum expiratory flow rates (Vmax) at lower volume levels were assessed, as well as the "specific" conductance of the respiratory pathways (Gaw/TGV), the vital capacity (VC), total lung capacity (TLC), residual volume (RV), functional residual capacity (FRC), RV/TLC and FRC/TLC ratios and the one-second forced expiration of the vital capacity (FEV1) to evaluate obstruction of the respiratory pathways. Most markedly and most frequently abnormal were the values of Vmax, RV and of the RV/TLC ratio. These findings revealed that in almost all patients with CF there was already during the initial examination an obstruction of the peripheral respiratory pathways and hyperinflation of the lungs. During repeated measurement of the above values of lung function in 15 patients with cystic fibrosis during a period of 1--5 years when the patients increased in height by 10 cm on average, the above values did not deteriorate on average. There was, however, an individual variability of the investigated values during this period. The comprehensive treatment provided in our country prevented in patients with CF a deterioration of obstruction of the respiratory pathways during the period of investigation.

• MeSH
• celková kapacita plic MeSH
• cystická fibróza komplikace   patofyziologie   MeSH
• dítě MeSH
• dospělí MeSH
• funkční reziduální kapacita MeSH
• lidé MeSH
• mladiství MeSH
• obstrukce dýchacích cest etiologie   MeSH
• plíce patofyziologie   MeSH
• předškolní dítě MeSH
• respirační funkční testy MeSH
• reziduální objem plic MeSH
• vitální kapacita MeSH
• vrcholová výdechová rychlost MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• předškolní dítě MeSH
• Publikační typ
• časopisecké články MeSH

• MeSH
• dospělí MeSH
• lidé MeSH
• respirační funkční testy * MeSH
• těhotenství * MeSH
• vitální kapacita MeSH
• vrcholová výdechová rychlost MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• těhotenství * MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH

• MeSH
• dýchání MeSH
• funkční reziduální kapacita * MeSH
• hrudník fyziologie   MeSH
• lidé MeSH
• měření objemu plic * MeSH
• nemoci dýchací soustavy patofyziologie   MeSH
• plíce fyziologie   patofyziologie   MeSH
• poddajnost plic MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH