COVID-19 poškozuje buňky a tkáně oxidačním stresem, ale to v současné době není dost známo. Ochrana před volnými radikály by mohla zlepšit stav nemocných a snížit jejich počet. Některé antioxidanty a postupy jsou slibné a zaslouží si publikaci. Terapie COVID-19 infekce z hlediska oxidoredukčních stavů by měla probíhat následujícími fázemi: 1. Zabránit množení viru a oxidačnímu stresu (antioxidant flavonoid taxifolin?). Terapie antioxidanty má smysl jen tehdy, jde-li o převahu volných radikálů. Jinak by byla kontraproduktivní; 2. Bránit mutacím (selen a snad antioxidanty, protože volné radikály umí mutovat nukleové kyseliny. Koronarovir je monovláknová RNA). Tím by se mohlo zabránit vzniku mutované formy viru, na kterou ještě člověk nemá protilátky = zábrana druhé vlny infekce); 3. Zabít viry (pokud ještě zůstaly virulentní v těle a tak bránit se proti latentní infekci a opakování onemocnění, (UVB paprsky, viruscidní látky, kombinace antioxidantů, očkování, atd.).
Covid-19 damages cells and tissues by oxidative stress, but currently is not known enough. Protection from free radicals could improve the condition of patients and decrease the number of sicks. Some antioxidants and methods are promising and deserve publication. Therapy of COVID-19 infection termed oxidoreduction states should take place in the following phases: 1. Prevent the virus from multiplying and from oxidative stress (antioxidant flavonoid taxifolin?). Antioxidative therapy only makes sense when it comes about dominance of free radicals. Otherwise, it would be counterproductive; 2. Prevent mutations (selenium and probably antioxidants, because free radicals can mutate nucleic acids. Coronavirus is single-branched RNA). This could prevent the emergence of mutated form of virus, to which human does not yet have antibodies- prevention of second wave of infection); 3. Kill viruses (if they remained virulent in the body and so defend against latent infection and repetition of disease (UVB rays, virucidal substances, combination of antioxidants, vaccination, etc.).
- MeSH
- antioxidancia MeSH
- COVID-19 * patofyziologie prevence a kontrola terapie MeSH
- lidé MeSH
- oxidační stres MeSH
- volné radikály MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Epidemiologické studie terapie antioxidanty často nejsou úspěšné, ačkoliv oxidační stres byl hodnověrně prokázán. ROS látky mají svůj význam v signalizaci a zneškodňování bakterií, kvasinek, parazitů, virů leukocyty i nádorových buněk NK buňkami. Rovnováha mezi volnými radikály a antioxidanty je komplexní a pečlivě regulovaná. Její porušení vede k poškození homeostázy. Proto podání slabých prooxidantů je někdy pro prevenci nemocí užitečné (Halliwel, 2013). Oxidační stres znamená převahu ROS, resp. volných radikálů nad antioxidační obranou.
Epidemiological studies concerning on the therapy of antioxidants are not fully successful, despite the prove of oxidative stress. Reactive oxygen species (ROS) have a great importance in signalization and neutralisation of bacteries, yeasts, parasites, viruses with the help of leukocytes and tumor cells by NK cells. The balance between free radikals and antioxidants is complex and very carefully regulated. The disbalance of this system leeds to the disturbance of homeostasis. Therefore the application of weak prooxidants is sometimes useful for the prevention of deseases (Halliwel, 2013). Oxidative stress is characterised by the predominance of free radicals above the antioxidative defence.
- MeSH
- gastrointestinální nádory * patofyziologie MeSH
- lidé MeSH
- volné radikály * škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
BACKGROUND: The benefit of probiotics in newborn children in relation to allergy and general morbidity later in life appears to be controversial. Allergic diseases represent an increasingly important health problem worldwide in recent years. This is evident in all age groups. The occurrence of allergic illnesses also continues to rise exponentially, and thus the use of preventive and prognostic methods, particularly in children with an inherently higher risk of allergy, is gaining increased importance. Since the advent of probiotics the effect of probiosis on immunity through alterations of composition and function of the human gut microbiome has been increasingly studied. The exact mechanisms have not yet been clearly defined. The Academy of Sciences of the Czech Republic (The Czech Academy of Sciences has suggested that the expression of TH1 and TH2 cytokines in umbilical blood is associated with an increased risk of allergies. The counter -balance of Th1 and Th2 affect Immunoglobulin E (IgE) production and maturation of the gastrointestinal tract epithelium. CASE PRESENTATION: We examined IgE levels in 3000 samples of umbilical blood taken from children born into families with a positive history of allergy in one or both parents from 2007 to 2017. At the age of ten days, those with high IgE were given Colinfant Newborn (a lyophilized non-pathogenic strain of Escherichia.coli) for one month, three times weekly. At 15 months and three years we investigated the levels of Immunoglobulins E,A and G, and the incidence of illness and allergy. The results revealed that allergy and high umbilical IgE is strongly linked with family history (p ≤ 0.001). We also detected differences in seasonality, especially with regards to pollen allergies. Eighty percent of children treated with Colinfant Newborn had significantly reduced IgE and morbidity at 13-15 months and 3 years, and furthermore without any clinical signs of allergy. Normalization of Immunoglobulins A and G was seen in 90% of treated subjects (p ≤ 0.001). These levels significantly correlated with an almost negligible morbidity up to 4 years of life. Colinfant Newborn, a lyophilized strain of Esherichia coli (E. coli), and a normal component of intestinal flora, readily colonizes the intestinal tract. It's long term presence significantly stimulates the production of specific and non-specific intestinal antibodies. and optimalizes immune development through tolerance. In our study Colinfant Newborn reduced the incidence of infections later in life by safely and effectively normalizing immunoglobulin levels in the majority of treated patients. CONCLUSION: Our study strongly suggests as positive effect of physiological Escherichia coli on the microbiome of newborn children as evidenced by a significantly reduced incidence of allergy and morbidity when applied early in life. These benefits appear to be strongly strain specific.
- MeSH
- alergie diagnóza farmakoterapie MeSH
- biologická terapie metody MeSH
- časové faktory MeSH
- centra terciární péče MeSH
- fetální krev imunologie MeSH
- hospitalizace statistika a číselné údaje MeSH
- imunoglobulin E krev MeSH
- kohortové studie MeSH
- lidé MeSH
- mikrobiota MeSH
- následné studie MeSH
- novorozenec MeSH
- novorozenecký screening metody MeSH
- retrospektivní studie MeSH
- senzitivita a specificita MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
- Klíčová slova
- COLIFANT NEWBORN,
- MeSH
- anamnéza MeSH
- časná přecitlivělost * farmakoterapie krev prevence a kontrola MeSH
- dítě MeSH
- Escherichia coli imunologie MeSH
- fetální krev imunologie MeSH
- imunoglobulin A analýza imunologie MeSH
- imunoglobulin E analýza MeSH
- kojenec MeSH
- lidé MeSH
- morbidita MeSH
- novorozenec MeSH
- odběr fetální krve MeSH
- střevní mikroflóra imunologie účinky léků MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- MeSH
- komplikace těhotenství MeSH
- lidé MeSH
- plod * embryologie patologie MeSH
- plodová voda MeSH
- Check Tag
- lidé MeSH
Pain increased the number of free radicals in the body. Previously, we studied changes mainly in oxygen and nitroxide free radicals and described these changes relative to the lipids and saccharides. In this article we focus on changes relative to proteins. Assessment of AGE products (advanced glycation end-products) was carried out by measuring fluorescence. Patients were divided into two groups: 15 patients with acute pain and 17 patients with chronic pain. Acute pain was associated with a variety of surgical procedures and patients were examined before and after surgical procedures. The group of patients with chronic pain suffered from various types of chronic pain, but mainly back pain. In patients with acute pain, total protein (TP) decreased after surgery, as did the level of AGE and the AGE/TP ratio. Nonetheless, post-operative pain increased. In patients with chronic pain, neither total protein, AGE, or AGE/TP changed, despite significant pain relief being reported after treatment. Changes in proteins, as biochemical markers, before and after pain treatment did not show any significant changes. In patients with acute pain, the recorded changes only lasted for 3-5 days after the operation. While in chronic pain, there were no significant changes at all. The assumption that changes in proteins, as biomarkers, would have the same importance as changes in lipids and saccharides was not proven.
- MeSH
- akutní bolest krev terapie MeSH
- biologické markery krev MeSH
- chronická bolest krev terapie MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- měření bolesti metody MeSH
- opioidní analgetika terapeutické užití MeSH
- paracetamol terapeutické užití MeSH
- pooperační bolest krev terapie MeSH
- produkty pokročilé glykace krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
