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10 záznamů v Medvik Filtry

Článek online

Association of metabolic and genetic factors with cholesterol esterification rate in HDL plasma and atherogenic index of plasma in a 40 years old Slovak population

Rašlová, Katarína
Autor Autorita National Reference Centre for Familial Hyperlipoproteinemias, Slovak Medical University, Bratislava
Dobiášová, Milada
Autor Autorita Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
Hubáček, Jaroslav, 1966-
Autor Autorita Institute for Clinical and Experimental Medicine, Prague, Czech Republic, Third Department of Medicine, First School of Medicine, Charles University, Prague
Bencová, D
Autor Bencová, D Department of Anthropology, Faculty of Sciences, Comenius University, Bratislava
Siváková, Daniela, 1947-
Autor Autorita Department of Anthropology, Faculty of Sciences, Comenius University, Bratislava
Danková, Zuzana
Autor Autorita
Franeková, Janka
Autor Autorita Department of Laboratory Methods, Institute for Clinical and Experimental Medicine, Prague
Jabor, Antonín, 1953-
Autor Autorita Department of Laboratory Methods, Institute for Clinical and Experimental Medicine, Prague
Gašparovič, J
Autor Gašparovič, J
Vohnout, Branislav
Autor Autorita National Reference Centre for Familial Hyperlipoproteinemias, Slovak Medical University, Bratislava Department of Physiological and Clinical Nutrition, Faculty of Nursing and Health Professional Studies, Slovak Medical University, Bratislava

Physiological research. 2011 ; 60 (5) : 785-795.

Physiol. Res. (Print)
ISSN 0862-8408
Medvik
Zdroj

We assessed association between novel biomarkers of cardiovascular disease and conventional factors in 40 years old subjects (208 men and 266 women) from the general population of Slovakia. FERHDL (cholesterol esterification rate in HDL plasma), AIP – Atherogenic Index of Plasma [Log(TG/HDL-C)] as markers of lipoprotein particle size, and CILP2, FTO and MLXIPL polymorphisms, were examined in relation to biomarkers and conventional risk factors. Univariate analyses confirmed correlation between AIP, FERHDL and the most of measured parameters. Relations between AIP and CILP2, FTO and MLXIPL were not significant. However, CILP2 was significantly related to FERHDL in both genders. In multivariate analysis BMI was the strongest correlate of AIP levels. In a model where AIP was omitted, TG levels explained 43 % of the FERHDL variability in men, while in women HDL-C was the major determinant (42 %). In conclusions, FERHDL and AIP related to the known markers of cardiovascular risk provide means to express their subtle interactions by one number. Our novel finding of association between CILP2 polymorphism and FERHDL supports its role in lipid metabolism.

MeSH
dospělí MeSH
esterifikace MeSH
extracelulární matrix - proteiny genetika MeSH
genetická predispozice k nemoci epidemiologie genetika MeSH
HDL-cholesterol krev MeSH
hodnocení rizik MeSH
jednonukleotidový polymorfismus genetika MeSH
lidé MeSH
nemoci koronárních tepen epidemiologie genetika krev MeSH
prevalence MeSH
pyrofosfatasy genetika MeSH
rizikové faktory MeSH
statistika jako téma MeSH
Check Tag
dospělí MeSH
lidé MeSH
mužské pohlaví MeSH
ženské pohlaví MeSH
Publikační typ
práce podpořená grantem MeSH
Geografické názvy
Slovenská republika MeSH

Článek

Assessment of functional status of Slovak adults according to their smoking, physical activity and marital status

Česká antropologie. 2010 ; 60 (1) : 10-15.

Čes. antropol.
ISSN 1804-1876
Medvik
Zdroj

Biological age estimates the functional status of an individual (in comparison with the chronological peers). In this study we used a Borkan and Norris method (1980b) for assessment of biological age in adult Slovak women and men using bioimpedance, biochemical and anthropometrical parameters in the context of lifestyle behavior characteristics. Our findings revealed that healthy life-style such as sporting, no-smoking and living with partner may be associated with younger biological age.

MeSH
antropometrie metody MeSH
dospělí MeSH
financování organizované MeSH
interpretace statistických dat MeSH
kouření škodlivé účinky MeSH
lidé středního věku MeSH
lidé MeSH
manželský stav statistika a číselné údaje MeSH
senioři MeSH
stárnutí fyziologie MeSH
techniky cvičení a pohybu metody statistika a číselné údaje využití MeSH
věkové skupiny MeSH
životní styl MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Geografické názvy
Slovenská republika MeSH

Článek

Menopauzálny status, klimakterické symptómy a kvalita života slovenských žien
[Menopausal status, climacteric symptoms and quality of life of Slovak women]

Česká antropologie. 2010 ; 60 (1) : 27-34.

Čes. antropol.
ISSN 1804-1876
Medvik
Zdroj

The purpose of the study was to determine symptoms related to menopausal status, and their prevalence in two subgroups of the Slovak women divided on the basis of the WHO (1996) definition as pre- and postmenopausal. Two hundred and three women from different regions (Dubnica nad Váhom, Pezinok, Nové Zámky a Bratislava), of non-clinical population, ranging in age betwee n 40 and 59 years were investigated in crosssectional survey. Several aspects of the Menopause-Specific Questionnaire (Kaczmarek, 2000) were examined and compared between the two subgroups of women. Statistical analysis was accomplished with SPSS software (Version 17.0 for Windows) and graphical processing with Excel 2007. The results showed significant differences in issues related to menopausal symptoms, some psychological aspects, intellectual and physical activities between two subgroups of women. Particularly, in the items indicated bothers in night sweats (p < 0.05), ache in muscles and joints (p < 0.01), noticed pins and needles in hands and feet (p < 0.05), vaginal dryness during intercourse (p < 0.05), always with higher mean values (i.e. undesirable) in the postmenopausal women. Higher percentage of the premenopausal women had better sleep, they are more active in intellectual a and physical activities (not specified), than the postmenopausal women. Here we present the first data examining menopausal symptoms in non-clinical sample of women from Slovakia.

MeSH
dospělí MeSH
financování organizované MeSH
interpretace statistických dat MeSH
klimakterium fyziologie psychologie MeSH
kvalita života MeSH
lidé středního věku MeSH
lidé MeSH
menopauza fyziologie psychologie MeSH
postmenopauza MeSH
premenopauza MeSH
průzkumy a dotazníky MeSH
stárnutí fyziologie psychologie MeSH
volnočasové aktivity MeSH
životní styl MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
ženské pohlaví MeSH
Geografické názvy
Slovenská republika MeSH

Článek online

Apolipoprotein E polymorphism in relation to plasma lipid levels and other risk factors of atherosclerosis in two ethnic groups from Slovakia

Collegium antropologicum. 2006 ; 30 (2) : 387-394.

Medvik
Zdroj

The influence of apolipoprotein E (ApoE) genotypes on plasma lipid levels and interaction with other environmental factors was determined in two Slovakian population samples; 146 Romany and 351 Slovak individuals. The two samples differ significantly in the distribution of E3/3 genotypes (p<0.014) and E3/2 (p<0.035). Analysis of variance did not reveal any significant effect of the ApoE genotypes on any of the plasma lipid levels in the Romany individuals. In the Slovak sample the variation in plasma low-density lipoprotein cholesterol (LDL-C) levels was significantly associated with the ApoE genotypes (p=0.012). We detected decreased LDL-C concentrations in males with E2 genotype when compared with E3 and E4 carriers (p=0.008). Further, the E2 genotype was found to be associated with high triglycerides levels (p=0.009). The ethnic samples differ significantly in the prevalence of metabolic syndrome and in the case of males of diabetes. Both the Romany and the Slovak males can be considered as having a more atherogenic profile compared with the females.