The study explores the influence of long-term androgen supplementation (18 years) on bone metabolism in trans(gender) men. Thirty five trans(gender) men aged (47±4) were treated with adequate dose of testosterone. BMD was measured by DEXA at lumbar spine and neck and T score was determined. Biochemical parameters of bone turnover were measured in all patients. As compared with female and male age matched controls they showed a not significantly different T-score at spine [1.213±0.15 in trans(gender) men vs. 1.192±0.19 in females and 1.203±0.06 g/cm2 in males (p<0.01)]. BMD in the hip skeleton in trans(gender) men (0.950±g/cm2) was statistically higher than females (0.822±0.09) but not statistically different from normal males 0.988±0.06). Circulating biochemical markers of bone formation, and resorption were not different between the trans(gender) men, and matched controls. We conclude that BMD at the hip (site rich in cortical bone) after adequate dose of testosterone therapy is higher while it is not different at the spine (trabecular bone) in trans(gender) men even after 18 years of testosterone administration.
- MeSH
- androgeny farmakologie terapeutické užití MeSH
- dospělí MeSH
- hormonální substituční terapie * MeSH
- kostní denzita účinky léků MeSH
- lidé středního věku MeSH
- lidé MeSH
- transgender osoby * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
- MeSH
- komunikace MeSH
- lidé MeSH
- nádory ženských pohlavních orgánů * chirurgie komplikace psychologie MeSH
- poradenství MeSH
- rehabilitace MeSH
- sexuální chování * psychologie MeSH
- sexuální poruchy a poruchy pohlavní identity psychologie terapie MeSH
- terapie ultrafialovými paprsky škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
The aim was to follow-up gonadal functions in long-term survivors of acute myeloid leukemias (AML) after intensive chemotherapy based on high-doses of cytosine arabinoside (Ara-C) and anthracyclines in the study UHKT-911. Adult patients were treated with at least 3 cycles of chemotherapy including 1-3 courses of Ara-C 10 x 2000 mg/m2/12 h and daunorubicin (DNR) 2 x 45 mg/m2/d. Spermiologic examinations were performed in 7 men by the classic microscopic method and results were evaluated according to the WHOcriteria. Two patients (42- and 47-year-old) after DNR and Ara-C chemotherapy had nearly normal spermiologic findings. The semen of a 49-year-old patient contained normal numbers of spermatozoa with decreased velocity when examined 1 year after chemotherapy but 4 years later exhibited oligoasthenozoospermia. The patient received 4 cycles of Ara-C and DNR plus one cycle with etoposide 350 mg/m2 and mitoxantrone 30 mg/m2. Semen examination of two patients 55- and 59-year-old showed permanent oligoasthenozoospermia with only sporadic progressively motile spermatozoa which might not be compatible with fertilization by sexual intercourse. They received the same chemotherapy including cumulative doses of etoposide 500 mg/m2 and mitoxantrone 36 mg/m2. Semen of two patients after allogeneic bone marrow transplantation exhibited severe oligoasthenozoospermia with no motile spermatozoa. Permanent amenorrhea developed in two women (42- and 46-year-old) during chemotherapy with DNR, Ara-C, etoposide, and mitoxantrone which was not the case in three women (29-40 years old) treated without etoposide and mitoxantrone. Intensive chemotherapy with high-doses of Ara-C and DNR plus one cycle of etoposide and mitoxantrone may cause permanent gonadal dysfunction in middle-aged patients with AML.
- MeSH
- akutní nemoc MeSH
- amenorea chemicky indukované MeSH
- cytarabin aplikace a dávkování škodlivé účinky MeSH
- daunomycin aplikace a dávkování škodlivé účinky MeSH
- dospělí MeSH
- etoposid aplikace a dávkování škodlivé účinky MeSH
- lidé středního věku MeSH
- lidé MeSH
- mitoxantron aplikace a dávkování škodlivé účinky MeSH
- myeloidní leukemie farmakoterapie chirurgie MeSH
- protokoly antitumorózní kombinované chemoterapie škodlivé účinky MeSH
- spermie MeSH
- transplantace kostní dřeně MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- MeSH
- lidé MeSH
- mužská infertilita etiologie psychologie MeSH
- přehledová literatura jako téma MeSH
- psychický stres MeSH
- psychoanalytická teorie MeSH
- psychosomatické poruchy MeSH
- vztahy mezi matkou a dítětem MeSH
- ženská infertilita etiologie psychologie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- MeSH
- lidé MeSH
- manželství MeSH
- mužská infertilita diagnóza psychologie terapie MeSH
- osobní uspokojení MeSH
- přehledová literatura jako téma MeSH
- psychologické testy MeSH
- sexualita MeSH
- výzkum metody MeSH
- ženská infertilita diagnóza psychologie terapie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
