Clinical trials of fostamatinib in patients with rheumatoid arthritis showed blood pressure (BP) elevation using clinic measurements. The OSKIRA-ambulatory BP monitoring trial assessed the effect of fostamatinib on 24-hour ambulatory systolic BP (SBP) in patients with active rheumatoid arthritis. One hundred thirty-five patients were randomized to fostamatinib 100 mg twice daily (bid; n = 68) or placebo bid (n = 67) for 28 days. Ambulatory, clinic, and home BPs were measured at baseline and after 28 days of therapy. Primary end point was change from baseline in 24-hour mean SBP. Fostamatinib increased 24-hour mean SBP by 2.9 mm Hg (P = .023) and diastolic BP (DBP) by 3.5 mm Hg (P < .001) versus placebo. Clinic/home-measured BPs were similar to those observed with ambulatory BP monitoring. After treatment discontinuation (1 week), clinic BP values returned to baseline levels. Fostamatinib induced elevations in 24-hour mean ambulatory SBP and DBP. BP elevations resolved with fostamatinib discontinuation.
- MeSH
- ambulantní monitorování krevního tlaku MeSH
- antirevmatika terapeutické užití MeSH
- dospělí MeSH
- dvojitá slepá metoda MeSH
- hodnocení rizik MeSH
- hypertenze komplikace diagnóza farmakoterapie MeSH
- interval spolehlivosti MeSH
- lidé středního věku MeSH
- lidé MeSH
- multivariační analýza MeSH
- následné studie MeSH
- oxaziny terapeutické užití MeSH
- pyridiny terapeutické užití MeSH
- referenční hodnoty MeSH
- revmatoidní artritida komplikace diagnóza farmakoterapie MeSH
- rozvrh dávkování léků MeSH
- senioři MeSH
- sexuální faktory MeSH
- tyrosinkinasy antagonisté a inhibitory terapeutické užití MeSH
- věkové faktory MeSH
- výsledek terapie MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
- srovnávací studie MeSH
Control of hypertension remains sub-optimal with only half of patients achieving adequate control. The Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure guidelines recommend initial use of two antihypertensive agents in patients with stage 2 hypertension. This review discusses the drug combinations that have additive effects and those that do not provide additional benefit while increasing the adverse events. RECENT FINDINGS: Results from late-breaking trials have shown that combinations of a calcium channel blocker and angiotensin-converting enzyme inhibitor are superior to a diuretic with an angiotensin-converting enzyme inhibitor for reducing cardiovascular events. Additionally, in patients with vascular disease with relatively 'controlled' blood pressure at baseline, the combination of an angiotensin-converting enzyme inhibitor and angiotensin receptor blocker did not reduce cardiovascular endpoints compared with either monotherapy and modestly increased the incidence of adverse effects. SUMMARY: Combination therapy of antihypertensive agents (e.g. angiotensin-converting enzyme inhibitor/calcium channel blocker, angiotensin-converting enzyme inhibitor/diuretics, and angiotensin receptor blocker/diuretics) as initial therapy in stage 2 hypertension can lead to markedly improved blood pressure control in patients compared with monotherapeutic regimens.
- MeSH
- antihypertenziva aplikace a dávkování MeSH
- cerebrovaskulární poruchy komplikace patofyziologie MeSH
- fixní kombinace léků MeSH
- hypertenze farmakoterapie komplikace MeSH
- kombinovaná farmakoterapie MeSH
- komplikace diabetu komplikace patofyziologie MeSH
- lidé MeSH
- nemoci ledvin komplikace patofyziologie MeSH
- nemoci srdce komplikace patofyziologie MeSH
- Check Tag
- lidé MeSH
American journal of medicine, ISSN 0002-9343 ; vol. 121, suppl. 8A, August 2008
31 s. : il., tab. ; 28 cm
- MeSH
- ambulantní monitorování krevního tlaku MeSH
- antagonisté receptorů pro angiotenzin MeSH
- dysfunkce levé srdeční komory MeSH
- hypertenze MeSH
- inhibitory ACE MeSH
- kardiovaskulární nemoci prevence a kontrola MeSH
- rizikové faktory MeSH
- srdeční zástava MeSH
- Publikační typ
- sborníky MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- angiologie
- kardiologie
Contemporary cardiology
[1st ed.] xvi, 308 s. . il.
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- kardiologie
- angiologie
