- MeSH
- dítě MeSH
- hemangiom klasifikace patologie MeSH
- lidé MeSH
- melanom klasifikace patologie MeSH
- nádory oka * chirurgie klasifikace patologie radioterapie terapie MeSH
- oftalmologické chirurgické výkony klasifikace MeSH
- radioterapie klasifikace MeSH
- retinoblastom dějiny diagnóza farmakoterapie klasifikace patologie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- přehledy MeSH
BACKGROUND: We performed a survey using the modified EORTC Facility questionnaire (pFQ) to evaluate the human, technical and organizational resources of particle centers in Europe. MATERIAL AND METHODS: The modified pFQ consisted of 235 questions distributed in 11 sections accessible on line on an EORTC server. Fifteen centers from 8 countries completed the pFQ between May 2015 and December 2015. RESULTS: The average number of patients treated per year and per particle center was 221 (range, 40-557). The majority (66.7%) of centers had pencil beam or raster scanning capability. Four (27%) centers were dedicated to eye treatment only. An increase in the patients-health professional FTE ratio was observed for eye tumor only centers when compared to other centers. All centers treated routinely chordomas/chondrosarcomas, brain tumors and sarcomas but rarely breast cancer. The majority of centers treated pediatric cases with particles. Only a minority of the queried institutions treated non-static targets. CONCLUSIONS: As the number of particle centers coming online will increase, the experience with this treatment modality will rise in Europe. Children can currently be treated in these facilities in a majority of cases. The majority of these centers provide state of the art particle beam therapy.
- MeSH
- chondrosarkom radioterapie MeSH
- chordom radioterapie MeSH
- dítě MeSH
- elementární částice terapeutické užití MeSH
- lidé MeSH
- nádory kostí farmakoterapie MeSH
- nádory mozku radioterapie MeSH
- nádory oka radioterapie MeSH
- protonová terapie přístrojové vybavení metody statistika a číselné údaje MeSH
- protony terapeutické užití MeSH
- průzkumy a dotazníky MeSH
- radioterapie těžkými ionty přístrojové vybavení metody statistika a číselné údaje MeSH
- uhlík chemie terapeutické užití MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Evropa MeSH
Introduction: Lymphoma is a malignant disease that can affect several structures of the orbit and eye adnexa. In the area of orbit the non-Hodgkin‘s lymphoma (NHL) is typical, which may be indolent or aggressive. Indolent subtypes include MALT (mucosa-associated lymphoid tissue), follicular lymphoma (FL), lymphoplasmocytic lymphoma (LPL). Conversely, subtypes such as diffuse large cell lymphoma (DLBCL), mantle cell lymphoma (MCL) and Burkitt lymphoma (BL) are aggressive. The disease can be presented as primary or secondary malignancy of the orbit. Material and methods: A group of 35 patients from the Department of Ophthalmology, Faculty of Medicine, Comenius University in Bratislava in the period from January 1 2009 to December 31 2016 with diagnosed non-Hodgkin‘s lymphoma located in the area of the orbit. For all patients, the generally valid diagnostic criteria for the NHL in the eye area were met. We processed the first signs of disease, the proportion of women and men with NHL, the percentage of NHL types in the orbit area. Statistically, we evaluated the age at which NHL occurred in patients and evaluated the incidence of the disease over the reference period. We have statistically processed the forms of the applied therapy, their adverse effects, the recurrence of the disease, the presence of other malignancies in the lymphoma patient. Results: Of the total number of NHL patients in orbit region 13 (37%) were male and 22 (63%) female. The overall mean age at which lymphoma was diagnosed was 60 years. Median for the total age of patients was 61. In women, a slightly higher average age and median was found. On the other hand, lower values of both parameters were present in men. The modus of both sexes was the same, 70 years. We have seen various first symptoms in our group. We found that the most common symptom is red eye, and the rarest is the deterioration of the central visual acuity. The longest lasting symptom was swelling of eyelids (on average, up to 10 years) and the shortest described eye itching. Overall, the average duration of symptoms was 28 months, with a median of 13 months. In our group of patients were 3 % of LPL, 6 % of Burkitt’s lymphoma, 6 % of FL, 8 % of MCL, 17 % of DLBCL, and 60 % of malignant lymphoma. MALT lymphoma occurred in 62 % in orbital and 38 % in conjunctival localization. In 2 patients with MALT lymphoma of the conjunctiva to start with systemic therapy wasn't neccessary. In 21 patients with MALT lymphoma excisional biopsy or orbitotomy was the first step to diagnose lymphoma disease in 3 cases; in 18 patients the infiltration of the orbit or conjunctiva occured 1 to 3 years after primary diagnose of systemic lymphoma disease. In general, NHL localization was 29 % in conjunctiva and 71 % in the orbital area. In 9 % of the orbital lymphoma, we observed lymphoma ingrowth to the conjunctiva. Systemic therapy was initiated in patients in II. stage and higher stage of the disease according to the Ann Arbor system. Totally 63 % of the group were treated by systemic therapy. Recurrence occurred in 5 patients, representing 14 % of the observed, but only in one patient with MALT lymphoma. Preoperative and postoperative (excisional biopsy, orbitotomy) central visual acuity (CVA) stayed unchanged, postoperative swelling did not affect CVA, and CVA didn't change even during long-term follow-up. Conclusion: Careful differential diagnosis determines the therapy of the disease, since the primary symptoms are usually nonspecific for ocular lymphoma. Significant factors for therapy include tumor grading and clinical staging by AJCC 2009 (American Joint Committee on Cancer, Chicago, Illinois). Correct evaluation of the symptoms is an important step to indicate excisional biopsy or orbitotomy: After histopathological results we can start adequate therapy in the cooperation with oncohematologist.
- Klíčová slova
- orbitotomie,
- MeSH
- dávka záření MeSH
- diferenciální diagnóza MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- lymfom chirurgie diagnóza farmakoterapie klasifikace komplikace radioterapie MeSH
- nádory oka chirurgie diagnóza farmakoterapie komplikace radioterapie MeSH
- nádory orbity * diagnóza chirurgie terapie MeSH
- nehodgkinský lymfom * chirurgie diagnóza farmakoterapie komplikace radioterapie MeSH
- oftalmologické chirurgické výkony metody MeSH
- orbita chirurgie patologie MeSH
- recidiva MeSH
- retrospektivní studie MeSH
- senioři MeSH
- statistika jako téma MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- MeSH
- bronchogenní karcinom diagnóza komplikace MeSH
- karcinom komplikace patologie MeSH
- lidé MeSH
- metastázy nádorů diagnóza radioterapie MeSH
- nádory oka klasifikace radioterapie sekundární MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- hodnocení výsledků zdravotní péče metody statistika a číselné údaje MeSH
- lidé MeSH
- melanom chirurgie terapie MeSH
- nádory oka chirurgie komplikace radioterapie MeSH
- přežití po terapii bez příznaků nemoci MeSH
- prognóza MeSH
- radiochirurgie metody statistika a číselné údaje využití MeSH
- Check Tag
- lidé MeSH
- MeSH
- dávka záření MeSH
- diagnostické techniky oftalmologické využití MeSH
- lékařská onkologie metody trendy MeSH
- lidé MeSH
- magnetická rezonanční tomografie metody využití MeSH
- melanom diagnóza radioterapie MeSH
- nádory oka radioterapie MeSH
- přežití po terapii bez příznaků nemoci MeSH
- radiační onkologie metody trendy MeSH
- radiochirurgie metody využití MeSH
- statistika jako téma MeSH
- stereotaktické techniky využití MeSH
- výsledky a postupy - zhodnocení (zdravotní péče) MeSH
- Check Tag
- lidé MeSH
- Klíčová slova
- METASTRON,
- MeSH
- lidé MeSH
- metroragie radioterapie MeSH
- nádory kostí radioterapie sekundární MeSH
- nádory mozku radioterapie sekundární MeSH
- nádory oka radioterapie sekundární MeSH
- nádory rekta radioterapie MeSH
- obstrukce dýchacích cest MeSH
- paliativní medicína * metody MeSH
- radiační onkologie * metody trendy MeSH
- radiofarmaka aplikace a dávkování škodlivé účinky terapeutické užití MeSH
- radioizotopy stroncia * aplikace a dávkování škodlivé účinky terapeutické užití MeSH
- statistika jako téma MeSH
- Check Tag
- lidé MeSH
- MeSH
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- nádory oka chirurgie radioterapie terapie MeSH
- předškolní dítě MeSH
- retinoblastom chirurgie radioterapie terapie MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Geografické názvy
- Československo MeSH
