Bovine mastitis is an inflammation of the mammary gland, which could be the result of allergy, physical trauma, or invasion by pathogens as Streptococcus uberis. This pathogen is an environmental pathogen associated with subclinical and clinical intramammary infection (IMI) in both lactating and non-lactating cows, which can persist in the udder and cause a chronic infection in the mammary gland. In spite of the important economic losses and increased prevalence caused by S. uberis mastitis, virulence factors involved in bacterial colonization of mammary glands and the pathogenic mechanisms are not yet clear. In the last 30 years, several studies have defined adherence and internalization of S. uberis as the early stages in IMI. S. uberis adheres to and invades into mammary gland cells, and this ability has been observed in in vitro assays. Until now, these abilities have not been determined in vivo challenges since they have been difficult to study. Bacterial surface proteins are able to bind to extracellular matrix protein components such as fibronectin, collagen and laminin, as well as proteins in milk. These proteins play a role in adhesion to host cells and have been denominated microbial surface components recognizing adhesive matrix molecules (MSCRAMMs). This article aims to summarize our current knowledge on the most relevant properties of the potential factors involved in the early pathogenesis of S. uberis mastitis.

• MeSH
• mastitida skotu * patologie   MeSH
• mléčné žlázy zvířat mikrobiologie   patologie   MeSH
• mléko chemie   MeSH
• rizikové faktory MeSH
• skot MeSH
• Streptococcus fyziologie   MeSH
• streptokokové infekce * patologie   veterinární   MeSH
• zvířata MeSH
• Check Tag
• skot MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

• MeSH
• podpora zdraví MeSH
• zdravotní výchova MeSH
• zdravotnické služby MeSH
• Publikační typ
• periodika MeSH

• Konspekt
• Lékařské vědy. Lékařství
• NLK Obory
• zdravotní výchova
• veřejné zdravotnictví

• MeSH
• lékařství MeSH
• zdravotnická zařízení MeSH
• Publikační typ
• monografie MeSH

• Konspekt
• Veřejné zdraví a hygiena
• NLK Obory
• lékařství
• veřejné zdravotnictví
• management, organizace a řízení zdravotnictví

• MeSH
• balónková angioplastika MeSH
• diabetická noha chirurgie   rehabilitace   terapie   MeSH
• onychomykóza terapie   MeSH
• transplantace hematopoetických kmenových buněk MeSH
• Publikační typ
• abstrakt z konference MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Obory
• diabetologie

• MeSH
• nemoci štítné žlázy diagnóza   terapie   MeSH
• Publikační typ
• periodika MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Obory
• endokrinologie

• MeSH
• duševní poruchy MeSH
• duševní procesy MeSH
• duševní zdraví MeSH
• mozek MeSH
• nemoci nervového systému MeSH
• Publikační typ
• sborníky MeSH

• Konspekt
• Sociologie kultury. Kulturní život
• NLK Obory
• psychiatrie
• psychologie, klinická psychologie
• neurologie

• MeSH
• lékaři MeSH
• lékařství MeSH
• významné osobnosti MeSH
• Publikační typ
• rozhovory MeSH
• sborníky MeSH
• Geografické názvy
• Česká republika MeSH

• Konspekt
• Lékařské vědy. Lékařství
• NLK Obory
• lékařství

• MeSH
• sociální péče MeSH
• sociální práce MeSH
• sociologie MeSH
• Publikační typ
• periodika MeSH

• Konspekt
• Druhy sociální pomoci a služeb
• NLK Obory
• sociologie

• Klíčová slova
• technika výpočetní, aplikace, programování,
• Publikační typ
• příručky MeSH

BACKGROUND: Perioperative goal directed therapy (GDT) can substantially improve the outcomes of high risk surgical patients as shown by many clinical studies. However, the approach needs initial investment and can increase the already very high staff workload. These economic imperatives may be at least partly responsible for weak adherence to the GDT concept. A few models are available for the evaluation of GDT cost-effectiveness, but studies of real economic data based on a recent clinical trial are lacking. In order to address this we have performed a retrospective analysis of the data from the "Intraoperative fluid optimization using stroke volume variation in high risk surgical patients" trial (ISRCTN95085011). METHODS: The health-care payers perspective was used in order to evaluate the perioperative hemodynamic optimization costs. Hospital invoices from all patients included in the trial were extracted. A direct comparison between the study (GDT, N = 60) and control (N = 60) groups was performed. A cost tree was constructed and major cost drivers evaluated. RESULTS: The trial showed a significant improvement in clinical outcomes for GDT treated patients. The mean cost per patient were lower in the GDT group 2877 ± 2336€ vs. 3371 ± 3238€ in controls, but without reaching a statistical significance (p = 0.596). The mean cost of all items except for intraoperative monitoring and infusions were lower for GDT than control but due to the high variability they all failed to reach statistical significance. Those costs associated with clinical care (68 ± 177€ vs. 212 ± 593€; p = 0.023) and ward stay costs (213 ± 108€ vs. 349 ± 467€; p = 0.082) were the most important differences in favour of the GDT group. CONCLUSIONS: Intraoperative fluid optimization with the use of stroke volume variation and Vigileo/FloTrac system showed not only a substantial improvement of morbidity, but was associated with an economic benefit. The cost-savings observed in the overall costs of postoperative care trend to offset the investment needed to run the GDT strategy and intraoperative monitoring. TRIAL REGISTRATION: ISRCTN95085011.

• Publikační typ
• časopisecké články MeSH