Scheer Peter*
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The effect of enrofloxacin on the QT interval of the electrocardiogram was studied in 30 hospitalized dogs. The experimental group (n = 15) received enrofloxacin parenterally (subcutaneously) at a dose of 5 mg/kg twice daily and amoxicillin-clavulanate intravenously at a dose of 22 mg/kg three times daily. The control group (n = 15) received only amoxicillin-clavulanate. Electrocardiography was carried out for 5 min once daily for 6 days. The QT interval was corrected by four different formulae. No differences were found between the two groups or within each group for the duration of the study. On the last day of the study the average QT interval for the control and experimental groups was 213.2 ms and 202.9 ms, respectively. Enrofloxacin did not cause prolongation of the QT or corrected QT intervals. We can conclude that the parenteral administration of enrofloxacin in non-cardiac dogs does not adversely affect the electrocardiographic indicators (no prolongation of the QT or corrected QT interval) and does not induce ventricular arrhythmias. Parenteral use of enrofloxacin is thus safe and effective in non-cardiac dogs.
- Klíčová slova
- repolarizace, QT interval,
- MeSH
- bakteriální infekce farmakoterapie prevence a kontrola MeSH
- elektrokardiografie * účinky léků MeSH
- enrofloxacin * antagonisté a inhibitory farmakologie škodlivé účinky MeSH
- fluorochinolony farmakologie klasifikace škodlivé účinky MeSH
- injekce MeSH
- psi MeSH
- srdeční elektrofyziologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- psi MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
6 il.
The aim of the study was evaluate the influence of the probiotic Escherichia coli Nissle 1917 strain (Mutaflor® suspension) on bacterial translocation in cases of liver damage, damage to the intestinal mucosa, potential portal hypertension associated with possible development of oesophageal varices and on the bacterial population of the intestine during chronic experimental liver damage in the laboratory rat. Rats with liver damage induced by thioacetamide were divided into an experimental and control group. Experimental and control animals were applied Mutaflor and saline, respectively. Samples of blood, liver, lymph nodes and caecum for microbiological examination, of liver, duodenum and oesophagus for histological examination and of spleen for weight evaluation were collected. There were no significant differences between both groups of animals in the qualitative proportion of Staphylococcus spp., Enterococcus spp. and Proteus spp. cultured from the lymph nodes, blood and liver. The quantitative culture results on Enterococcus spp. in the caecum, liver and lymph nodes showed no significant differences between both groups. There was a significant difference between the experimental and control group in the counts of coliform bacteria. No significant differences between both groups were found in the overall damage score of the liver, duodenum and oesophagus. There were no differences in the spleen to body weight ratio of both groups. The application of Mutaflor® suspension for eight days had no recognisable effect diminishing the selected complications of chronic liver damage caused by the administration of TAA to laboratory rats.
BACKGROUND/AIMS: In surgical sepsis, the rapid identification of source of infection at an early stage after surgery or serious trauma is crucial for favorable outcome. The discrimination between local and generalized infection is critical for correct treatment. METHODOLOGY: In a randomized, controlled, single-centre study we investigated 72 patients with severe sepsis after major abdominal surgery or surgery for multiple trauma. Patients were divided in 2 groups: in the first group (PCT, n=38), more important role in the treatment decision was given to PCT level (severe sepsis with PCT >2 ng/mL signalled bacteremia and pushed us to change antibiotics and intravascular devices, severe sepsis with PCT < or =2 ng/mL prompted use of ultrasonography and/or CT, followed by repeated surgery in patients with localized infection). The control group (CON, n=34) was treated by standard evaluation of all parameters by consultant surgeon. We investigated 28-day all-cause mortality, sepsis-related complications, the duration of stay in the intensive care unit, and ventilated days. RESULTS: The hospital mortality was in PCT group 26% and 38% in control group (p = 0.28). Average SOFA score was 7.9 +/- 2.8 in PCT group vs. 9.3 +/- 3.3 (p = 0.06). The decline of ICU days (16.1 +/- 6.9 vs. 19.4 +/- 8.9; p = 0.09) and ventilated days (10.3 +/- 7.8 vs. 13.9 +/- 9.4; p = 0.08) in PCT group was observed, but the difference was not significant. CONCLUSIONS: We observed a clear tendency to decrease extent of multiple organ dysfunction syndrome in patients, in which therapeutic decision was made earlier using procalcitonin as an additional marker separating local infection from generalized one.
- MeSH
- biologické markery krev MeSH
- břicho chirurgie MeSH
- dospělí MeSH
- financování organizované MeSH
- infekce spojené se zdravotní péčí chirurgie mortalita MeSH
- jednotky intenzivní péče MeSH
- kalcitonin krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- metody pro podporu rozhodování MeSH
- multiorgánové selhání diagnóza chirurgie mortalita MeSH
- polytrauma chirurgie mortalita MeSH
- pooperační komplikace chirurgie mortalita MeSH
- prediktivní hodnota testů MeSH
- proteinové prekurzory krev MeSH
- reoperace MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- sepse chirurgie mortalita MeSH
- skóre závažnosti úrazu MeSH
- umělé dýchání MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- randomizované kontrolované studie MeSH
BACKGROUND/AIMS: Brain natriuretic peptide is recently widely used as a diagnostic and prognostic marker of heart failure. Plasma levels of this peptide are elevated in other, non-cardiac conditions as well, among others in liver cirrhosis, especially presenting with fluid retention and,--ascites. METHODS: Circulating levels of BNP was determined in 25 non-cardiac patients, 20 men, 5 women admitted at our medicine department from March 2006 to September 2007 with decompensate ascitic liver cirrhosis. Severity of disease was measured by Child and MELD (Model of End Stage of Liver Disease) score. RESULTS: Plasma BNP was increased in our patients (range 21-1078 pg/ml) and significantly correlated with the severity of liver failure assigned as Child's classification (r = 0.51; p = 0.009) and MELD score (r = 0.56; p = 0.003) as well as with the glomerular filtration rate (r = -0.62; p = 0.0009). Four patients with initial BNP > 600 ng/L died, while all 21 patients with BNP < 600 ng/L survived (p = 0.0019). CONCLUSION: B-type natriuretic peptide in plasma correlated significantly with the severity of liver disease in cirrhotic patients. High plasma BNP seems to be a good negative prognostic factor of the death in cirrhosis.
- MeSH
- biologické markery krev MeSH
- dospělí MeSH
- jaterní cirhóza krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- míra přežití MeSH
- natriuretický peptid typu B krev MeSH
- neparametrická statistika MeSH
- regresní analýza MeSH
- senioři MeSH
- stupeň závažnosti nemoci MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Klíčová slova
- D-dimery,
- MeSH
- antikoagulancia terapeutické užití MeSH
- Aspirin * farmakologie MeSH
- biologické markery MeSH
- haptoglobiny účinky léků MeSH
- inhibitory agregace trombocytů MeSH
- kardiostimulace umělá * škodlivé účinky MeSH
- králíci MeSH
- počet leukocytů MeSH
- tromboembolie * diagnóza krev prevence a kontrola MeSH
- vyšetření krevní srážlivosti klasifikace metody MeSH
- zánět krev MeSH
- žilní tromboembolie diagnóza prevence a kontrola MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
- srovnávací studie MeSH
