bioindicator
Dotaz
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- MeSH
- agregace trombocytů MeSH
- Aspirin aplikace a dávkování farmakologie MeSH
- finanční podpora výzkumu jako téma MeSH
- inhibitory cyklooxygenasy farmakologie metabolismus MeSH
- klinické laboratorní techniky přístrojové vybavení statistika a číselné údaje MeSH
- koronární nemoc farmakoterapie MeSH
- léková rezistence fyziologie genetika MeSH
- lidé MeSH
- propylgalan diagnostické užití MeSH
- titrace MeSH
- Check Tag
- lidé MeSH
Toxic metals (Hg, Cd, Pb) and fifteen perfluoroalkyl substances (PFASs) were determined in different fish samples at two locations on the Elbe River in the Czech Republic. The muscle tissue of the two adult fish species most commonly used as bioindicators in central Europe and whole body homogenates of various species of young-of-the-year (YOY) fish were used. The purpose of this study was to evaluate the potential to replace adult fish muscle tissue with YOY fish for contamination monitoring. All of the toxic metals and five of the fifteen PFASs were found in the YOY fish samples while only mercury and PFOS were detected in the muscle tissue of adults. The concentration of total mercury (THg) in the YOY fish homogenates ranged between 0.014 and 0.062 μg g(-1). Of the spectrum of analysed pollutants, only the THg concentrations were lower in YOY fish homogenates than in adult muscle tissue. The cadmium concentration varied from 0.004 to 0.024 μg g(-1) and the lead concentration varied from 0.032 to 0.396 μg g(-1) in YOY fish homogenates, while in most of the adult samples, Cd and Pb were below the detection limit of the analytical methods employed. The PFOS concentrations in YOY fish homogenates were comparable to the concentrations frequently found in adult liver tissue. These results show that mixed shoals of YOY fish can be successfully used for aquatic bio-monitoring. Interspecific variability in the concentrations of the target pollutants in YOY fish whole body homogenates is usually lower than the intraspecific variability of the concentrations of the pollutants in adult fish muscle. YOY fish were found to be a suitable bioindicator and have several advantages compared to adult fish.
- MeSH
- chemické látky znečišťující vodu * MeSH
- monitorování životního prostředí * MeSH
- prospektivní studie MeSH
- rtuť MeSH
- ryby MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Oxid dusnatý (NO) je produkován ve vysokých koncentracích v horních dýchacích cestách. Vysoké koncentrace NO mají toxický účinek na bakterie a viry, čímž napomáhají obraně sliznice respiračního traktu. V posledních letech roste ve světě zájem o měření nazálního oxidu dusnatého (nNO) u onemocnění horních dýchacích cest, např. u ciliární dyskineze, adenoidních vegetací, alergické rýmy či akutní a chronické rinosinusitidy. Měření nNO v otorinolaryngologii je však prozatím ve stadiu experimentu a jeho význam pro klinickou praxi bude třeba studovat v rozsáhlejších prospektivních studiích.
Nitric oxide (NO) is produced in high concentration in the upper respiratory tract. The high concentration of NO is toxic to bacteria and viruses and thus helps to defend the mucous membranes of upper respiratory tract. In recent years is an increasing worldwide interest in the measurement of nasal nitric oxide (nNO) in diseases of the upper respiratory tract. In the literature, are starting to publish work about the measurement of nasal nitric oxide in ciliary dyskinesia, adenoid vegetation, allergic rhinitis or acute and chronic rhinosinusitis. The measurement of nasal nitric oxide in otorhinolaryngology is based only on several experimental studies yet. More clinical data are necessary to consider a true impact for clinical treatment.
- Klíčová slova
- nazální oxid dusnatý, adenoidní vegetace, rinosinusitida, chemiluminiscenční analyzátor,
- MeSH
- alergická rýma diagnóza MeSH
- dechové testy MeSH
- infekce dýchací soustavy * diagnóza MeSH
- Kartagenerův syndrom diagnóza MeSH
- lidé MeSH
- luminiscenční měření MeSH
- nosní sliznice metabolismus MeSH
- oxid dusnatý * analýza biosyntéza fyziologie metabolismus MeSH
- rýma diagnóza MeSH
- sinusitida diagnóza MeSH
- vydechnutí MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Synthetic musk fragrances, which are contained in almost all scented consumer products, enter aquatic environment mainly by way of wastewater paths. To monitor contamination of the Vltava River by these relatively persistent chemicals in the surroundings of Prague industrialized agglomeration, chub (Leuciscus cephalus) was employed as a bioindicator. Validated gas chromatography-mass spectrometry method was used for fish sample examination. Polycyclic musks, represented by 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-(gamma)-2-benzopyran (galaxolide) and 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)-ethanone (tonalide) were the most abundant representatives of this group; their levels in fillets were in the range of 1.7 to 105.9 microg/kg and 0.9 to 19.3 microg/kg wet weight, respectively. Nitro-musks, musk ketone, and musk xylene were also detected in most samples; nevertheless, their levels were lower,
- MeSH
- chemické látky znečišťující vodu analýza MeSH
- Cyprinidae metabolismus MeSH
- ekosystém MeSH
- financování organizované MeSH
- kyseliny mastné mononenasycené analýza MeSH
- monitorování životního prostředí metody MeSH
- parfém analýza MeSH
- plynová chromatografie s hmotnostně spektrometrickou detekcí MeSH
- řeky chemie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- MeSH
- chromozomální aberace MeSH
- krmivo pro zvířata analýza MeSH
- látky znečišťující vzduch toxicita MeSH
- mutageny analýza MeSH
- Salmonella typhimurium účinky léků MeSH
- skot MeSH
- testy genotoxicity MeSH
- zvířata genetika MeSH
- Check Tag
- skot MeSH
- ženské pohlaví MeSH
- zvířata genetika MeSH
- Publikační typ
- srovnávací studie MeSH
Correlative imaging of cutaneous tumors provides additional information to the standard histopathologic examination. However, the joint progress in the establishment of analytical techniques, such as Laser-Induced Breakdown Spectroscopy (LIBS) and Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) in clinical practice is still limited. Their combination provides complementary information as it is also shown in our study in terms of major biotic (Ca, Mg, and P) and trace (Cu and Zn) elements. To elucidate changes in the elemental composition in tumors, we have compiled a set of malignant tumors (Squamous Cell Carcinoma, Basal Cell Carcinoma, Malignant Melanoma, and Epithelioid Angiosarcoma), one benign tumor (Pigmented Nevus) and one healthy-skin sample. The data processing was based on a methodological pipeline involving binary image registration and affine transformation. Thus, our paper brings a feasibility study of a practical methodological concept that enables us to compare LIBS and LA-ICP-MS results despite the mutual spatial distortion of original elemental images. Moreover, we also show that LIBS could be a sufficient pre-screening method even for a larger number of samples according to the speed and reproducibility of the analyses. Whereas LA-ICP-MS could serve as a ground truth and reference technique for preselected samples.
- MeSH
- bazocelulární karcinom diagnostické zobrazování MeSH
- hmotnostní spektrometrie metody MeSH
- laserová terapie MeSH
- lasery MeSH
- lidé MeSH
- melanom diagnostické zobrazování patologie MeSH
- nádory kůže * diagnostické zobrazování patologie MeSH
- pigmentový névus diagnostické zobrazování MeSH
- spektrální analýza metody MeSH
- spinocelulární karcinom diagnostické zobrazování patologie MeSH
- stopové prvky analýza MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
