conformation
Dotaz
Zobrazit nápovědu
- MeSH
- aldehydoxidoreduktasy MeSH
- buněčná membrána MeSH
- fluorescence MeSH
- králíci MeSH
- lipidy MeSH
- liposomy MeSH
- Check Tag
- králíci MeSH
Ciba Foundation symposium ; 161
269 s. : obr., tab., bibliogr. přeruš.
We report on the synthesis of novel conformationally locked nucleoside and nucleotide derivatives, which are structurally closely related to clinically used antivirals such as didanosine and abacavir. As a suitable conformationally rigid substitute of the sugar/pseudosugar ring allowing a permanent stabilization of the nucleoside in North conformation we employed bicyclo[2.2.1]heptane (norbornane) substituted in the bridgehead position with a hydroxymethyl group and in the C-3 position with a nucleobase. Prepared nucleoside derivatives were also converted into appropriate phosphoramidate prodrugs (ProTides) in order to increase delivery of the compounds in the cells. All target compounds were evaluated in a broad antiviral and cytostatic assay panel.
- MeSH
- antivirové látky chemická syntéza MeSH
- konformace nukleové kyseliny MeSH
- lidé MeSH
- norbornany chemická syntéza chemie MeSH
- nukleosidy chemická syntéza chemie MeSH
- nukleotidy chemická syntéza chemie MeSH
- stereoizomerie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
