multi-experimental analysis
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... Features of gait 3 -- 1.4 Model-based versus model-free gait assessment 4 -- 1.5 Applications of gait analysis ... ... Statistics and computational intelligence in clinical gait analysis 17 -- 2.1 Introduction 17 -- 2.2 ... ... Low-cost sensors for gait analysis 25 -- 3.1 Introduction 25 -- 3.2 Motion capture sensors for gait 25 ... ... A low-cost electromyography (EMG) sensor-based gait activity analysis 101 -- 8.1 Introduction 101 -- ... ... 114 -- 8.7 Gait analysis using surface electromyography sensors 118 -- 8.8 Summary 124 -- References ...
x, 179 stran : ilustrace, grafy, schémata, portréty
Multi-criteria decision-making (MCDM) can be formally implemented by various methods. This study compares suitability of four selected MCDM methods, namely WPM, TOPSIS, VIKOR, and PROMETHEE, for future applications in agent-based computational economic (ACE) models of larger scale (i.e., over 10 000 agents in one geographical region). These four MCDM methods were selected according to their appropriateness for computational processing in ACE applications. Tests of the selected methods were conducted on four hardware configurations. For each method, 100 tests were performed, which represented one testing iteration. With four testing iterations conducted on each hardware setting and separated testing of all configurations with the-server parameter de/activated, altogether, 12800 data points were collected and consequently analyzed. An illustrational decision-making scenario was used which allows the mutual comparison of all of the selected decision making methods. Our test results suggest that although all methods are convenient and can be used in practice, the VIKOR method accomplished the tests with the best results and thus can be recommended as the most suitable for simulations of large-scale agent-based models.
- MeSH
- ekonomické modely MeSH
- lidé MeSH
- metody pro podporu rozhodování MeSH
- rozhodování * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Capillary electrophoresis-frontal analysis (CE-FA) together with mobility shift affinity CE is the most frequently used mode of affinity CE for a study of plasma protein-drug interactions, which is a substantial part of the early stage of drug discovery. Whereas in the classic CE-FA setup the sample is prepared by off-line mixing of the interaction partners in the sample vial outside the CE instrument and after a short incubation period loaded into the capillary and analysed, in this work a new methodological approach has been developed that combines CE-FA with the mixing of interacting partners directly inside the capillary. This combination gives rise to a fully automated and versatile methodology for the characterization of these binding interactions besides a substantial reduction in the amounts of sample compounds used. The minimization of possible experimental errors due to the full involving of sophisticated CE instrument in the injection procedure, mixing and separation instead of manual manipulation is another fundamental benefit. The in-capillary mixing is based on the transverse diffusion of laminar flow profile methodology introduced by Krylov et al. using its multi-zone injection modification presented by Řemínek at al.. Actually, after the method optimization, the alternate introduction of six plugs of drug and six plugs of bovine serum protein in BGE, each injected for 3 s at a pressure of -10 mbar (-1 kPa) into the capillary filled by BGE, was found to be the best injection procedure. The method repeatability calculated as RSDs of plateau highs of bovine serum albumin and propranolol as model sample compounds were better than 3.44 %. Its applicability was finally demonstrated on the determination of apparent binding parameters of bovine serum albumin for basic drugs propranolol and lidocaine and acid drug phenylbutazone. The values obtained by a new on-line CE-FA methodology are in agreement with values estimated by classic off-line CE-FA, as well as with literature data obtained using different techniques.
Wiley series in probability and statistics
Second edition xvii, 633 stran : ilustrace ; 24 cm
Delayed fluorescence (DF) is a long-lived luminescence process used in a variety of applications ranging from oxygen sensing in biological tissues to organic Light Emitting Diodes. In common cases, DF results from the de-excitation of the first excited triplet state via the first excited singlet state of the chromophore, which produces a mono-exponential light signal whose amplitude and lifetime give an insight into the probed environment. However, non-linear de-excitation reactions such as triplet-triplet annihilation, which can cause decays to lose their mono-exponential nature, are often neglected. In this work, we derive a global framework to properly interpret decays resulting from a combination of linear and non-linear de-excitation processes. We show why the standard method of using multi-exponential models when decays are not mono-exponential is not always relevant, nor accurate. First, we explain why the triplet de-excitation and light production processes should be analyzed individually: we introduce novel concepts to precisely describe these two processes, namely the deactivation pathway - the reaction which mainly contributes to the triplet state de-excitation - and the measurement pathway - the reaction which is responsible for light production. We derive explicit fitting functions which allow the experimenter to estimate the reaction rates and excited state concentrations in the system. To validate our formalism, we analyze the in vitro Transient Triplet Absorption and DF of Protoporphyrin IX, a well-known biological aromatic molecule used in photodynamic therapy, cancer photodetection and oxygen sensing, which produces DF through various mechanisms depending on concentration and excitation intensity. We also identify the precise assumptions necessary to conclude that triplet-triplet annihilation DF should follow a mono-exponential decay with a lifetime of half the triplet state lifetime. Finally, we describe why the commonly used definitions of triplet / DF lifetime are ill-defined in the case where second-order reactions contribute to the deactivation process, and why the fitting of precise mixed-orders DF kinetics should be preferred in this case. This work could allow the correct interpretation of various long-lived luminescence processes and facilitate their understanding.
- MeSH
- fluorescence MeSH
- fluorescenční spektrometrie MeSH
- kinetika MeSH
- protoporfyriny chemie MeSH
- teoretické modely MeSH
- Publikační typ
- časopisecké články MeSH
... Antitumor Photosensitizer Hypericin with Human -- Serum Albumin; Molecular Modeling Study Based on Experimental ... ... Gaga ls к a -- Two-Component Analysis of v^y^CHj Bands Reveals Different Lipid-Domains in 110 -- Thylakoid ... ... Vicent -- Analysis of Ca and AI Polygalacturonate by Means of FT-Raman Spectroscopy 116 -- C. ... ... Lawrence -- Experimental and Calculated Spectra of Selected Phosphonatepyridene Acids. ... ... Proniewicz -- Spectroscopic Analysis (IR, Raman and RX) of Polymorphism of Gepirone 127 -- Hydrochloride ...
2 sv. (150 s., s. 151-274) : il., tab. ; 25 cm
The aim of this study is to obtain by Monte Carlo method the high energy photon flux due to neutron capture in the internals and vessel layers of the experimental reactor LR-0 located in REZ, Czech Republic, and loaded with VVER-1000 fuel. The calclated neutron, photon and photon to neutron flux ratio are compared with experimental measurements performed with a multi-parameter stilbene detector. The results show clear underestimation of photon flux in downcomer and some overestimation at vessel surface and 1/4 thickness but a good fitting for deeper points in vessel.
- MeSH
- analýza selhání vybavení MeSH
- dávka záření MeSH
- elektrárny přístrojové vybavení normy MeSH
- fotony * MeSH
- metoda Monte Carlo MeSH
- počítačová simulace MeSH
- radiační ochrana přístrojové vybavení metody MeSH
- radiační rozptyl MeSH
- radiometrie metody MeSH
- statistické modely * MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
- MeSH
- dítě MeSH
- jazyková terapie metody psychologie MeSH
- komunikační poruchy * rehabilitace terapie MeSH
- lidé MeSH
- osoby s mentálním postižením * psychologie MeSH
- péče o pacienta metody využití MeSH
- porucha chování rehabilitace terapie MeSH
- rodiče psychologie MeSH
- role lékaře psychologie MeSH
- skupinová psychoterapie * metody MeSH
- statistika jako téma MeSH
- studenti MeSH
- výzkumný projekt MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
