Comparison of the genomes of free-living Bodo saltans and those of parasitic trypanosomatids reveals that the transition from a free-living to a parasitic life style has resulted in the loss of approximately 50% of protein-coding genes. Despite this dramatic reduction in genome size, B. saltans and trypanosomatids still share a significant number of common metabolic traits: glycosomes; a unique set of the pyrimidine biosynthetic pathway genes; an ATP-PFK which is homologous to the bacterial PPi -PFKs rather than to the canonical eukaryotic ATP-PFKs; an alternative oxidase; three phosphoglycerate kinases and two GAPDH isoenzymes; a pyruvate kinase regulated by fructose-2,6-bisphosphate; trypanothione as a substitute for glutathione; synthesis of fatty acids via a unique set of elongase enzymes; and a mitochondrial acetate:succinate coenzyme A transferase. B. saltans has lost the capacity to synthesize ubiquinone. Among genes that are present in B. saltans and lost in all trypanosomatids are those involved in the degradation of mureine, tryptophan and lysine. Novel acquisitions of trypanosomatids are components of pentose sugar metabolism, pteridine reductase and bromodomain-factor proteins. In addition, only the subfamily Leishmaniinae has acquired a gene for catalase and the capacity to convert diaminopimelic acid to lysine.

A A Kharkevich Institute for Information Transmission Problems Russian Academy of Sciences Moscow 127 051 Russia

Biology Centre Institute of Parasitology Czech Academy of Sciences České Budějovice 370 05 Czech Republic

Canadian Institute for Advanced Research Toronto ON M5G 1Z8 Canada

e Duve Institute Université Catholique de Louvain Brussels B 1200 Belgium

Faculty of Science Institute of Environmental Technologies University of Ostrava Ostrava 710 00 Czech Republic

Faculty of Science University of South Bohemia České Budějovice 370 05 Czech Republic

Life Science Research Centre Faculty of Science University of Ostrava Ostrava 710 00 Czech Republic

Citace poskytuje Crossref.org

Distribution and Functional Analysis of Isocitrate Dehydrogenases across Kinetoplastids

In silico prediction of the metabolism of Blastocrithidia nonstop, a trypanosomatid with non-canonical genetic code

Leishmania guyanensis M4147 as a new LRV1-bearing model parasite: Phosphatidate phosphatase 2-like protein controls cell cycle progression and intracellular lipid content

Comparative Analysis of Three Trypanosomatid Catalases of Different Origin

Catalase impairs Leishmania mexicana development and virulence

Genomics of Trypanosomatidae: Where We Stand and What Needs to Be Done?

Differences in mitochondrial NADH dehydrogenase activities in trypanosomatids

A New Model Trypanosomatid, Novymonas esmeraldas: Genomic Perception of Its "Candidatus Pandoraea novymonadis" Endosymbiont

Genome Analysis of Endotrypanum and Porcisia spp., Closest Phylogenetic Relatives of Leishmania, Highlights the Role of Amastins in Shaping Pathogenicity

The Remarkable Metabolism of Vickermania ingenoplastis: Genomic Predictions

Large-Scale Phylogenetic Analysis of Trypanosomatid Adenylate Cyclases Reveals Associations with Extracellular Lifestyle and Host-Pathogen Interplay

Genetic tool development in marine protists: emerging model organisms for experimental cell biology

Catalase and Ascorbate Peroxidase in Euglenozoan Protists

Evolution of metabolic capabilities and molecular features of diplonemids, kinetoplastids, and euglenids

If host is refractory, insistent parasite goes berserk: Trypanosomatid Blastocrithidia raabei in the dock bug Coreus marginatus

LmxM.22.0250-Encoded Dual Specificity Protein/Lipid Phosphatase Impairs Leishmania mexicana Virulence In Vitro

Comparative genomics of Leishmania (Mundinia)

Genomic Variation among Strains of Crithidia bombi and C. expoeki

RNA Viruses in Blechomonas (Trypanosomatidae) and Evolution of Leishmaniavirus

Leptomonas pyrrhocoris: Genomic insight into Parasite's Physiology