- MeSH
- Argyria * etiology pathology MeSH
- Diagnosis, Differential MeSH
- Silver Nitrate MeSH
- Humans MeSH
- Young Adult MeSH
- Foot MeSH
- Pigmentation MeSH
- Check Tag
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Publication type
- Case Reports MeSH
OBJECTIVE: Argyria is generally classified as localized or generalized condition. Distinct pigmentation of the oral mucosa in the vicinity of amalgam fillings is often referred to as amalgam tattoos. Pigmented areas can also be associated with silver-containing corrosion products of dental alloys used for prosthetic restorations. Silver-containing electron dense particles (Ag-EDPs) are frequently found in pigmented areas. We attempted to correlate results of the elemental composition of Ag-EDPs with excerpts from health profiles of our study paticipants. DESIGN/SETTING: Eight patients with diagnosed signs of localized argyria were investigated in this study. Biopsies from distinctly pigmented gingival areas were subjected to histological examination, electron microscopy and x-ray microanalysis. RESULTS: Elemental composition of Ag-EDPs determined by x-ray microanalysis showed mainly silver in combination with sulfur or selenium or a combination of both chalcogens. Elemental analyzes results of Ag-EDPs were analyzed along with excerpts from the patient's clinical records. Two patients with low or undetectable selenium in the Ag-EDPs suffered from autoimmune thyroiditis, Parkinson's disease, bronchial asthma, and allergies to molds, pollen and dust. CONCLUSIONS: We suggest that selenium in Ag-EDPs is a product of the detoxification process for Ag(+) ions in gingival tissue and that it may reflect the availability of endogenous selenium for physiological processes in the human body. Its presence or absence might thus be used as another marker of a patient's health status.
- MeSH
- Argyria metabolism MeSH
- Adult MeSH
- Gingiva chemistry metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Electron Probe Microanalysis MeSH
- Young Adult MeSH
- Mouth Diseases chemically induced metabolism MeSH
- Pigmentation MeSH
- Selenium analysis metabolism MeSH
- Aged MeSH
- Silver metabolism MeSH
- Microscopy, Electron, Transmission MeSH
- Mouth metabolism MeSH
- Mouth Mucosa metabolism MeSH
- Dental Prosthesis adverse effects MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
These nanomaterials are already having an impact on health care. Now-a-days we are using nanoproducts in various fields. Of these, silver nanoparticles are playing a major role in the field of nanotechnology and nanomedicine. Their unique size-dependent properties make these materials superior and indispensable as they show unusual physical, chemical and biological properties. Silver nanoparticles have potential antimicrobial activity towards many pathogenic microbes. Along with this antimicrobial activity, silver nanoparticles are showing unacceptable toxic effects on human health and the environment. The chronic exposure to silver causes adverse effects such as permanent bluish-grey discoloration of the skin (argyria) and eyes (argyrosis). Besides argyria and argyrosis, exposure to soluble silver compounds may produce other toxic effects like liver and kidney damage, irritation of the eyes, skin, respiratory and intestinal tract and changes to blood cells. This review summarizes the hazardous effects of silver nanoparticles in the environment and theirs toxic effects on human health.
- MeSH
- Anti-Infective Agents therapeutic use toxicity MeSH
- Argyria etiology immunology metabolism MeSH
- Financing, Organized MeSH
- Metal Nanoparticles adverse effects toxicity MeSH
- Humans MeSH
- Nanomedicine methods trends MeSH
- Nanotechnology methods trends MeSH
- Silver Compounds adverse effects toxicity MeSH
- Silver adverse effects toxicity MeSH
- Toxic Actions metabolism adverse effects MeSH
- Environmental Pollution adverse effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Nemoc (demence) s argyrofilními zrny (AgD) patří mezi neurodegenerativní onemocnění spojená s hromaděním patologické hyperfosforylované formy tau proteinu. Klinicky se obvykle projevuje jako demence v pozdním séniu a její diagnostika je do současné doby možná pouze posmrtným neu- ropatologickým vyšetřením mozkové tkáně. Neuropatologické vyšetření mozkové tkáně 83letého muže a 91leté ženy s klinicky diagnostikovanou demencí bez bližší specifikace bylo doplněno im- pregnací solemi stříbra a imunohistochemickým průkazem tau proteinu monoklonálními protilát- kami proti jeho hyperfosforylované formě. Morfologický obraz AgD je charakterizován přítomnos- tí početných argyrofilních zrn v neuropilu a specifickými perinukleárními inkluzemi v subkorti- kálních oligodendrogliích v oblasti spánkových laloků. V obou vyšetřovaných případech byla spl- něna diagnostická kritéria definitivní AgD. Jedná se o první popis tohoto dle literárních údajů re- lativně častého neurodegenerativního onemocnění v České republice.
Argyrophilic grain disease (AgD) is a relatively newly described neurodegenerative disease with late-onset dementia. Morphologically it is characterized by the presence of abundant spindle- shaped argyrophilic grains (ArG) in neuronal processes and coiled bodies in oligodendrocytes. ArG consist of abnormally hyperphosphorylated form of tau protein. AgD is a substrate of at least 5% of all dementia cases with increasing incidence in the old age. Here we report the cases of a 91-year- old woman and an 83-year-old man clinically diagnosed with dementia. Neuropathological, histochemical and immunohistochemical examination of the brain tissue show the changes to be compatible with a definite diagnosis of AgD. This is the first description of two cases of AgD in the Czech Republic.
- MeSH
- Argyria diagnosis pathology MeSH
- Dementia diagnosis pathology MeSH
- Hippocampus pathology MeSH
- Immunohistochemistry methods MeSH
- Humans MeSH
- Antibodies, Monoclonal diagnostic use MeSH
- Neurodegenerative Diseases diagnosis pathology MeSH
- tau Proteins MeSH
- Silver Compounds diagnostic use MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- Geographicals
- Czech Republic MeSH
- MeSH
- Argyria etiology surgery MeSH
- Adult MeSH
- Endodontics adverse effects MeSH
- Humans MeSH
- Root Canal Therapy adverse effects MeSH
- Dental Amalgam adverse effects MeSH
- Dental Pins adverse effects MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
