- Keywords
- Wobenzym plus, Phlogenzym,
- MeSH
- Arthralgia * drug therapy MeSH
- Osteoarthritis, Knee * drug therapy MeSH
- Bromelains administration & dosage MeSH
- Diclofenac administration & dosage MeSH
- Adult MeSH
- Double-Blind Method MeSH
- Enzyme Therapy * MeSH
- Drug Combinations MeSH
- Middle Aged MeSH
- Humans MeSH
- Multicenter Studies as Topic MeSH
- Randomized Controlled Trials as Topic MeSH
- Rutin analogs & derivatives administration & dosage MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Trypsin administration & dosage MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Keywords
- Phlogenzym, Wobenzym,
- MeSH
- Osteoarthritis, Knee * drug therapy MeSH
- Bromelains administration & dosage MeSH
- Diclofenac administration & dosage MeSH
- Adult MeSH
- Enzyme Therapy * MeSH
- Drug Combinations MeSH
- Middle Aged MeSH
- Humans MeSH
- Multicenter Studies as Topic MeSH
- Randomized Controlled Trials as Topic MeSH
- Rutin analogs & derivatives administration & dosage MeSH
- Aged MeSH
- Trypsin administration & dosage MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Publication type
- Newspaper Article MeSH
- Keywords
- TMEM70, komplex V, ATPsyntáza,
- MeSH
- Organelle Biogenesis MeSH
- Cell Line MeSH
- Energy Metabolism physiology MeSH
- Fumarate Hydratase administration & dosage MeSH
- Humans MeSH
- Protein Interaction Mapping methods utilization MeSH
- Membrane Proteins genetics chemistry metabolism MeSH
- Mitochondrial ADP, ATP Translocases MeSH
- Mitochondrial Proteins biosynthesis deficiency MeSH
- Mitochondrial Proton-Translocating ATPases genetics deficiency MeSH
- Mitochondria * enzymology MeSH
- Oxidative Phosphorylation MeSH
- Prospective Studies MeSH
- Mitochondrial Membrane Transport Proteins MeSH
- Trypsin administration & dosage MeSH
- Binding Sites MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Článek shrnuje možnosti využití léků pro systémovou enzymoterapii při řešení nejrůznějších poruch pohybového aparátu. Hlavními účinnými látkami těchto léků jsou proteolytické enzymy živočišného a rostlinného původu s rutinem. Nejznámější jsou jejich účinky protiotokové a protizánětlivé, které se velmi dobře uplatňují u stavů po úrazech a operacích. Lze je ale využít i při konzervativní léčbě degenerativních chorob pohybového aparátu a nejrůznějších bolestivých syndromů zahrnovaných pod pojem revmatismus měkkých tkání. Zde se mimo jiné velmi dobře uplatňuje také jejich analgetický efekt. Jsou prezentovány hlavně novější studie a práce českých autorů. Upozorňujeme také na některé experimentální práce, které přispívají k objasnění podstaty účinků jednotlivých proteáz i jejich směsí obsažených v lécích pro systémovou enzymoterapii.
The paper summarizes possibilities of the use of systemic enzyme therapy for locomotor apparatus disorders. The main active components of these medicaments are proteolytic enzymes of animal and plant origin with rutin. Their antiedematous and antiinflammatory effects are well known and are usable in the treatment of conditions after an injury and a surgery. Medicaments for systemic enzyme therapy are as well suitable for conservative treatment of degenerative disorders of locomotor apparatus and various painful syndromes classified as soft tissue rheumatism. Analgetic effect of systemic enzyme therapy is very useful in these disorders. The newer clinical trials and experience of Czech author are mainly presented in this paper.
- Keywords
- Wobenzym, Phlogenzym,
- MeSH
- Analgesics administration & dosage pharmacology therapeutic use MeSH
- Anti-Inflammatory Agents, Non-Steroidal adverse effects therapeutic use MeSH
- Anti-Inflammatory Agents administration & dosage pharmacology therapeutic use MeSH
- Arthritis drug therapy complications therapy MeSH
- Bromelains administration & dosage pharmacology therapeutic use MeSH
- Child MeSH
- Adult MeSH
- Edema drug therapy therapy MeSH
- Enzyme Therapy * methods trends MeSH
- Drug Combinations MeSH
- Humeral Fractures surgery complications MeSH
- Risk Assessment MeSH
- Hydrolases administration & dosage pharmacology therapeutic use MeSH
- Musculoskeletal Diseases * drug therapy therapy MeSH
- Postoperative Care methods MeSH
- Peptide Hydrolases administration & dosage pharmacology therapeutic use MeSH
- Randomized Controlled Trials as Topic MeSH
- Rheumatic Diseases drug therapy complications therapy MeSH
- Rutin analogs & derivatives pharmacology therapeutic use MeSH
- Carpal Tunnel Syndrome drug therapy therapy MeSH
- Trypsin administration & dosage pharmacology therapeutic use MeSH
- Intervertebral Disc Displacement surgery complications MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- MeSH
- Enzyme Therapy MeSH
- Enzymes MeSH
- Humans MeSH
- Trypsin administration & dosage therapeutic use MeSH
- Check Tag
- Humans MeSH
V imunologických ambulancích Ústavu imunologie, alergologie a mikrobiologie 1. LF UK a VFN Praha aplikujeme, většinou s velmi dobrým efektem, trypsin pacientům s klinickými (subfebrilie, atralgie, myalgie, únava) a laboratorními známkami zánětu. Vzhledem k jeho známým schopnostem urychlení hojení byl tento preparát použit i u pacientky s leukocytoklastickou vaskulitidou. V práci je popsána podrobná kazuistika a jsou zde uvedeny známé mechanismy působení proteáz a jejich receptorů. Vzhledem k tomu, že leukocytoklastická vaskulitida patří k nejčastěji se vyskytujícím typům vaskulitid, zabýváme se tímto onemocněním a jeho doporučovanou terapií podrobněji. Terapie trypsinem nemůže nahradit klasickou protizánětlivou, nebo dokonce imunosupresivní léčbu, ale jistě je vhodným doplňkem u komplikovaných pacientů a nebo naopak postačující monoterapií u pacientů s dosud nejasně vyhraněným imunopatologickým onemocněním cév.
In the immunological out-patient departments of the Institute of Immunology. Alergology and Microbiology of the First Medical Faculty Charles University and General Faculty Hospital, Prague the authors administer with a very satisfactory effect trypsin to patients with clinical (subfebrile temperatures, arthralgia, myalgia, fatigue) and laboratory signs of inflammation. With regard to its known properties of accelerated healing this preparation was used also in a female patient with leukocytoclastic vasculitis. The authors describe the detailed tase-history and mention known mechanismy of the action of proteases and their receptors. As leukocytoclastic vascuatis is one of the most frequent types of vasculitis the authors discuss this disease and its recommended therapy in more detail. Trypsin therapy can replace classical anti-inflammatory or even immunosuppressive treatment and certainly is a suitable supplement in complicated patients, or conversely sufficient monotherapy in patients with a hitherto not clearly defined immunopathological vascular disease.
- MeSH
- Biopsy MeSH
- Adult MeSH
- Enzyme Therapy MeSH
- Enzymes MeSH
- Clinical Laboratory Techniques statistics & numerical data MeSH
- Vasculitis, Leukocytoclastic, Cutaneous diagnosis etiology drug therapy MeSH
- Humans MeSH
- Trypsin administration & dosage pharmacology MeSH
- Inflammation diagnosis etiology drug therapy MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- Review MeSH
- Keywords
- TRYPSIN RETARD SPOFA,
- MeSH
- Humans MeSH
- Trypsin administration & dosage therapeutic use MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- MeSH
- Chymotrypsin administration & dosage MeSH
- Endopeptidases administration & dosage MeSH
- Humans MeSH
- Multiple Myeloma drug therapy MeSH
- Papain administration & dosage MeSH
- Antineoplastic Combined Chemotherapy Protocols therapeutic use MeSH
- Trypsin administration & dosage MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
