- Keywords
- mikronizovaná purifikovaná flavonoidní frakce,
- MeSH
- Varicose Ulcer etiology therapy MeSH
- Diosmin administration & dosage pharmacology therapeutic use MeSH
- Flavonoids pharmacology therapeutic use MeSH
- Hesperidin administration & dosage pharmacology therapeutic use MeSH
- Wound Healing MeSH
- Cardiovascular Agents administration & dosage pharmacology toxicity MeSH
- Humans MeSH
- Venous Insufficiency * complications physiopathology therapy MeSH
- Check Tag
- Humans MeSH
- Keywords
- Detralex,
- MeSH
- Diosmin administration & dosage pharmacology MeSH
- Flavonoids pharmacology therapeutic use MeSH
- Hesperidin administration & dosage pharmacology MeSH
- Dosage Forms MeSH
- Humans MeSH
- Drug Synergism MeSH
- Venous Insufficiency * drug therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Newspaper Article MeSH
Správně nasazená léčba ověřeným venofarmakem představuje zásadní krok ke zlepšení kvality života pacientů s chronickým žilním onemocněním, prevenci progrese onemocněnía redukci rizika žilních a kožních změn. Tři prezentované kazuistiky dokládají také souvislostmezi compliance či noncompliance pacientů a účinnou kontrolou žilního onemocnění.
Properly implemented treatment with a proven venopharmaceutical is a crucial step inimproving the quality of life of patients with chronic venous disease, as well as preventingdisease progression and reducing the risk of venous and cutaneous changes. The three pre-sented case reports also demonstrate a connection between the patients' compliance ornoncompliance and the effective control of venous disease
- Keywords
- Detralex,
- MeSH
- Treatment Adherence and Compliance MeSH
- Varicose Ulcer drug therapy MeSH
- Diosmin administration & dosage MeSH
- Flavonoids administration & dosage MeSH
- Hesperidin administration & dosage MeSH
- Middle Aged MeSH
- Humans MeSH
- Postthrombotic Syndrome drug therapy MeSH
- Treatment Outcome MeSH
- Venous Insufficiency * drug therapy MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Case Reports MeSH
- Keywords
- DETRALEX,
- MeSH
- Defecation MeSH
- Hemorrhoids * drug therapy pathology prevention & control MeSH
- Hesperidin * administration & dosage therapeutic use MeSH
- Pantothenic Acid analogs & derivatives administration & dosage therapeutic use MeSH
- Humans MeSH
- Young Adult MeSH
- Rectum pathology MeSH
- Check Tag
- Humans MeSH
- Young Adult MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- Keywords
- Detralex,
- MeSH
- Varicose Ulcer * drug therapy MeSH
- Diosmin administration & dosage pharmacology MeSH
- Flavones pharmacology therapeutic use MeSH
- Hesperidin administration & dosage pharmacology MeSH
- Middle Aged MeSH
- Humans MeSH
- Varicose Veins drug therapy surgery MeSH
- Treatment Outcome MeSH
- Venous Insufficiency drug therapy MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- Keywords
- Detralex,
- MeSH
- Flavonoids * administration & dosage pharmacology therapeutic use MeSH
- Flavones administration & dosage pharmacology MeSH
- Hesperidin administration & dosage pharmacology MeSH
- Humans MeSH
- Plant Extracts pharmacology MeSH
- Venous Insufficiency drug therapy MeSH
- Check Tag
- Humans MeSH
Chronické žilní onemocnění (CVD – chronic venous disease) představuje celosvětově závažný zdravotní problém, protože jeho prevalence je vysoká – až 84 % populace včetně pacientů s klinickým stadiem C0 (studie Vein Consult Program z roku 2012). Základní součástí konzervativní léčby jsou venoaktivní léky (VAD – venoactive drugs). V roce 2014 byla publikována nová doporučení pro léčbu CVD. Došlo ke změně klasifikace VAD s ohledem na jejich bezpečnost a účinnost. Mikronizovaná purifikovaná flavonoidní frakce (MPFF) je podle nových doporučení jediným venoaktivním lékem se stupněm doporučení 1B (doporučení silné, kvalita důkazů střední – nejvyšší stupeň doporučení). Rutosidy, extrakt z listů červené vinné révy, calcium dobesilát, extrakt ze semen koňského kaštanu a extrakt z listnatce mají stupeň doporučení 2B, nemikronizované diosminy a Gingko biloba pak 2C. MPFF je indikována pro všechna stadia CVD a jako jediný venoaktivní lék je doporučována u léčby žilních bércových vředů.
Chronic venous disease (CVD) represents a major health problem, as its prevalence is high – up to 84% of population including patients with clinical stage C0 (Vein Consult Programme, 2012). Venoactive drugs (VAD) are a basic conservative treatment of CVD. New guidelines for the treatment of CVD were published in 2014. There are changes in classification of VAD based on their safety and efficacy. Micronized purified flavonoid fraction (MPFF) is now the only VAD with grade 1B (a strong recommendation based on moderate evidence). Rutosides, red wine leaves extracts, calcium dobesilate, horse chestnut seed extract and Ruscus extract are all given grade 2B (weak recommendations based on moderate evidence). Nonmicronized diosmins and Gingko biloba are given grade 2C (weak recommendations based on low quality evidence). MPFF is indicated in all stages of CVD and it is the only VAD recommendated in the treatment of venous leg ulcers.
- Keywords
- chronické žilní onemocnění, mikronizovaná purifikovaná flavonoidní frakce, GRADE,
- MeSH
- Varicose Ulcer drug therapy MeSH
- Chronic Disease MeSH
- Diosmin administration & dosage therapeutic use MeSH
- Escin therapeutic use MeSH
- Drug Combinations MeSH
- Flavonoids administration & dosage classification therapeutic use MeSH
- Hesperidin administration & dosage therapeutic use MeSH
- Calcium Dobesilate adverse effects therapeutic use MeSH
- Capillary Permeability drug effects MeSH
- Humans MeSH
- Vascular Diseases * drug therapy physiopathology pathology MeSH
- Plant Extracts therapeutic use MeSH
- Rutin therapeutic use MeSH
- Practice Guidelines as Topic MeSH
- Veins * drug effects MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Keywords
- Detralex,
- MeSH
- Uterine Hemorrhage etiology drug therapy MeSH
- Diosmin administration & dosage MeSH
- Hesperidin administration & dosage MeSH
- Levonorgestrel administration & dosage MeSH
- Middle Aged MeSH
- Humans MeSH
- Intrauterine Devices, Copper * adverse effects MeSH
- Venous Insufficiency drug therapy MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Diosmin administration & dosage MeSH
- Hesperidin administration & dosage MeSH
- Wound Healing * drug effects MeSH
- Humans MeSH
- Bandages, Hydrocolloid MeSH
- Aged, 80 and over MeSH
- Leg Ulcer etiology nursing therapy MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Aged, 80 and over MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- Keywords
- DETRALEX,
- MeSH
- Patient Compliance MeSH
- Chronic Disease therapy MeSH
- Lower Extremity physiopathology MeSH
- Adult MeSH
- Hesperidin * administration & dosage therapeutic use MeSH
- Stockings, Compression utilization MeSH
- Humans MeSH
- Obesity therapy MeSH
- Varicose Veins pathology MeSH
- Treatment Outcome MeSH
- Venous Insufficiency * diagnosis prevention & control therapy MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
