Formaldehyde
Dotaz
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Health and Safety Guide, ISSN 0259-7268 No. 57
48 s. : tab., lit.
- Konspekt
- Chemie. Mineralogické vědy
- NLK Obory
- chemie, klinická chemie
- toxikologie
- NLK Publikační typ
- publikace WHO
... 48 -- REFERENCES 49 -- APPENDIX 1 — SOURCE DOCUMENT 61 -- APPENDIX 2 — CICAD PEER REVIEW 62 -- Formaldehyde ...
Concise international chemical assessment document, ISSN 1020-6167 no. 40
75 s. : tab., grafy ; 36 cm
This work concerns the role of formaldehyde in the environment and describes the basic indoor and outdoor detection techniques. One of the laboratory techniques, laser photoacoustic spectroscopy, was used for detection of formaldehyde based on its absorption spectrum in a region around 4350 cm-1. A new type of diode laser (GaInAsSb/AlGaAsSb - MQW (Multi-quantum well)) operating at room temperature in combination with a simple resonance photoacoustic cell provides the minimum detectable signal of formaldehyde, ca. 1250 µg m-3, at 4356 cm-1.
Environmental health criteria ; 89
219 s. : tab.
- MeSH
- chemické látky - účinky a užití MeSH
- environmentální zdraví MeSH
- formaldehyd MeSH
- hodnocení rizik MeSH
- znečištění životního prostředí MeSH
- Konspekt
- Lékařské vědy. Lékařství
- NLK Obory
- toxikologie
- hygiena
- NLK Publikační typ
- publikace WHO
- MeSH
- formaldehyd škodlivé účinky MeSH
- zdraví MeSH
- znečištění vzduchu ve vnitřním prostředí MeSH
- Geografické názvy
- Rakousko MeSH
Methanol, an aliphatic alcohol widely used in the industry, causes acute and chronic intoxications associated with severe long-term health damage, including permanent visual impairment, brain damage, mainly necrosis of the basal ganglia and high mortality due to cancer. However, the role of formaldehyde, an intermediate metabolite of methanol oxidation, in methanol toxicity remains unclear. Thus, we studied the reactivity of several amino acids and peptides in the presence of formaldehyde by identifying products by direct infusion electrospray high-resolution mass spectrometry (MS) and matrix-assisted laser desorption-ionization MS. Cysteine, homocysteine and two peptides, CG and CGAG, provided cyclic products with a +12 amu mass shift with respect to the original compounds. The proposed structures of the products were confirmed by high-resolution tandem MS. Moreover, the formation of the products with +12 amu mass shift was also shown for two biologically relevant peptides, fragments of ipilimumab, which is a human IgG1 monoclonal antibody against cytotoxic T-lymphocyte-associated protein 4. Overall, our experimental results indicate that formaldehyde reacts with some amino acids and peptides, yielding covalently modified structures. Such chemical modifications may induce undesirable changes in the properties and function of vital biomolecules (e.g., hormones, enzymes) and consequently pathogenesis.
