Path analysis
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34 stran ; 30 cm
- MeSH
- kvalita zdravotní péče MeSH
- ošetřovatelská péče MeSH
- péče o pacienta MeSH
- Publikační typ
- abstrakty MeSH
- kongresy MeSH
- sborníky MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- ošetřovatelství
- veřejné zdravotnictví
Path integration, the ability to track one's position using self-motion cues, is critically dependent on the grid cell network in the entorhinal cortex, a region vulnerable to early Alzheimer's disease pathology. In this study, we examined path integration performance in individuals with subjective cognitive decline (SCD), a group at increased risk for Alzheimer's disease, and healthy controls using an immersive virtual reality task. We developed a Bayesian computational model to decompose path integration errors into distinct components. SCD participants exhibited significantly higher path integration error, primarily driven by increased memory leak, while other modeling-derived error sources, such as velocity gain, sensory, and reporting noise, remained comparable across groups. Our findings suggest that path integration deficits, specifically memory leak, may serve as an early marker of neurodegeneration in SCD and highlight the potential of self-motion-based navigation tasks for detecting presymptomatic Alzheimer's disease-related cognitive changes.
- MeSH
- Alzheimerova nemoc patofyziologie MeSH
- Bayesova věta MeSH
- cortex entorhinalis patofyziologie MeSH
- kognice * MeSH
- kognitivní dysfunkce * patofyziologie diagnóza MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- virtuální realita MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROND: One of the important areas of heart research is to analyze heart rate variability during (HRV) walking. OBJECTIVE: In this research, we investigated the correction between heart activation and the variations of walking paths. METHOD: We employed Shannon entropy to analyze how the information content of walking paths affects the information content of HRV. Eight healthy students walked on three designed walking paths with different information contents while we recorded their ECG signals. We computed and analyzed the Shannon entropy of the R-R interval time series (as an indicator of HRV) versus the Shannon entropy of different walking paths and accordingly evaluated their relation. RESULTS: According to the obtained results, walking on the path that contains more information leads to less information in the R-R time series. CONCLUSION: The analysis method employed in this research can be extended to analyze the relation between other physiological signals (such as brain or muscle reactions) and the walking path.
- MeSH
- časové faktory MeSH
- chůze * MeSH
- elektrokardiografie * MeSH
- entropie MeSH
- lidé MeSH
- srdeční frekvence fyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Elektrochemická detekce biomolekul se neustále posouvá a má velký potenciál využití v klinické praxi. V posledních letech je kladen důraz na přesné a rychlé stanovení biomarkerů na bázi nukleových kyselin – DNA a RNA. Značná část výzkumných projektů však nereflektuje požadavky na demonstraci vyvinutých metod na klinickém materiálu, což jejich aplikační potenciál značně snižuje. Klinický materiál vnáší do výzkumu oproti modelovým vzorkům větší variabilitu a práce s ním vyžaduje specifické podmínky. Problém získávání klinického materiálu pro výzkumné účely z velké části řeší banky biologického materiálu, které mohou nabídnout vzorky a data vhodné pro konkrétní výzkumný záměr.
Precise diagnostics of cancer or other diseases is crucial when selecting proper treatment. Personalized medicine puts high demands on the accuracy of nucleic acid biomarkers analysis, where subtle differences at the nucleotide level are often involved. Isothermal amplification techniques offer new possibilities of DNA and RNA amplification without using PCR, and their combination with electrochemistry provide a promising fast and cost-effective alternative diagnostic tool. Although electrochemical biosensors are still insufficiently applied to clinical material, thus hindering their development, recent advancements show great promise in translational research. Banks of biological material (biobanks) are specialized workplaces focused on the long-term preservation and processing of clinical material and offer a wide range of expert services, primarily for research purposes, in particular the provision of biological samples and associated pseudonymized data. Their involvement in the field of electrochemical biosensors can facilitate application of electrochemical methods into clinical laboratories and expand the portfolio of currently used diagnostic methods.
- MeSH
- banky biologického materiálu MeSH
- biosenzitivní techniky metody MeSH
- elektrochemické techniky * metody MeSH
- nádorové biomarkery * analýza klasifikace MeSH
- techniky amplifikace nukleových kyselin metody MeSH
- translační biomedicínský výzkum MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
svazky : ilustrace
- MeSH
- biochemická analýza krve MeSH
- klinická chemie metody MeSH
- laboratorní medicína * MeSH
- Publikační typ
- periodika MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- hematologie a transfuzní lékařství
The notion that mitochondria cannot be lost was shattered with the report of an oxymonad Monocercomonoides exilis, the first eukaryote arguably without any mitochondrion. Yet, questions remain about whether this extends beyond the single species and how this transition took place. The Oxymonadida is a group of gut endobionts taxonomically housed in the Preaxostyla which also contains free-living flagellates of the genera Trimastix and Paratrimastix. The latter two taxa harbour conspicuous mitochondrion-related organelles (MROs). Here we report high-quality genome and transcriptome assemblies of two Preaxostyla representatives, the free-living Paratrimastix pyriformis and the oxymonad Blattamonas nauphoetae. We performed thorough comparisons among all available genomic and transcriptomic data of Preaxostyla to further decipher the evolutionary changes towards amitochondriality, endobiosis, and unstacked Golgi. Our results provide insights into the metabolic and endomembrane evolution, but most strikingly the data confirm the complete loss of mitochondria for all three oxymonad species investigated (M. exilis, B. nauphoetae, and Streblomastix strix), suggesting the amitochondriate status is common to a large part if not the whole group of Oxymonadida. This observation moves this unique loss to 100 MYA when oxymonad lineage diversified.
- MeSH
- Eukaryota * genetika MeSH
- fylogeneze MeSH
- genomika MeSH
- mitochondrie genetika MeSH
- Oxymonadida * genetika metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
Despite extensive evidence on the impact of various mental health issues including smartphone/internet addiction, and personality traits on academic achievement, little is known about the complex interactions between multiple of these factors simultaneously, as well as cross-country differences in these nuanced relationships. In particular, understanding the role of the mentioned addictions has become increasingly important in recent years in the context of the COVID-19 pandemic. The aim of this cross-country study was to investigate, using path analysis, the complex relationships between mental health determinants (depression, anxiety, stress, resilience, and smartphone/internet addiction) and academic achievement in 1785 Czech and Chinese university students using an online battery of psychological tests. The results confirmed the previously described effect of multiple factors (anxiety, stress, resilience, smartphone/internet addiction, personality traits, and sex, Extraversion, Agreeableness, Conscientiousness) on academic achievement, overlapping in most cases for both groups of students. At the same time, however, different country-dependent patterns of interactions emerged. For the Czech students, the variables formed a complex network of interacting factors, whereas for the Chinese students, the effect of each cluster of factors was separate for individual domains of academic achievement. These cross-country differences have implications particularly for planning and targeting the most effective interventions to promote and develop academic achievement.
- MeSH
- chytrý telefon MeSH
- COVID-19 * psychologie epidemiologie MeSH
- deprese psychologie MeSH
- dospělí MeSH
- duševní zdraví MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- návykové chování psychologie MeSH
- netholismus * psychologie MeSH
- osobnost * MeSH
- školní úspěšnost * MeSH
- srovnání kultur MeSH
- studenti * psychologie statistika a číselné údaje MeSH
- univerzity MeSH
- úzkost psychologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
- Čína MeSH
Walking is an everyday activity in our daily life. Because walking affects heart rate variability, in this research, for the first time, we analyzed the coupling among the alterations of the complexity of walking paths and heart rate. We benefited from the fractal theory and sample entropy to evaluate the influence of the complexity of paths on the complexity of heart rate variability (HRV) during walking. We calculated the fractal exponent and sample entropy of the R-R time series for nine participants who walked on four paths with various complexities. The findings showed a strong coupling among the alterations of fractal dimension (an indicator of complexity) of HRV and the walking paths. Besides, the result of the analysis of sample entropy also verified the obtained results from the fractal analysis. In further studies, we can analyze the coupling among the alterations of the complexities of other physiological signals and walking paths.
- Publikační typ
- časopisecké články MeSH
Various studies within the Good-Enough Approach observe that people often make errors in answering comprehension questions after reading garden-path sentences such as While Anna dressed the baby played in the crib. Recently, it has been claimed that readers form a full syntactic analysis of these sentences, but they do not completely prune the original misanalysis. This article presents evidence that these findings do not hold for all garden-path sentences. The main finding of the Good-Enough Approach-that the comprehension questions targeting the initial misanalysis yield significantly higher rates of incorrect answers after garden-path sentences, in comparison with after control sentences-was replicated here in three self-paced reading experiments on Czech. However, these experiments show a similar pattern of results for other comprehension questions, such as questions targeting an analysis that is not syntactically licensed at any point of processing. These results point out that certain garden-path structures may be very hard to process and that the process of garden-path repair might not be successful at all. Based on these results and the results of previous studies, the idea of a range of difficulty levels for garden-path structures is proposed.
- MeSH
- čtení MeSH
- jazyk (prostředek komunikace) * MeSH
- lidé MeSH
- pochopení * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
