PURPOSE: Autonomic imbalance as measured by heart rate variability (HRV) has been associated with poor outcome after stroke. Observations on HRV changes in intracerebral hemorrhage (ICH) are scarce. Here, we aimed to investigate HRV in ICH as compared to a control group and to explore associations with stroke severity, hemorrhage volume and outcome after ICH. METHODS: We examined the autonomic modulation using frequency domain analysis of HRV during the acute phase of the ICH and in a healthy age- and hypertension-matched control group. Hematoma volume, intraventricular extension, initial stroke severity and baseline demographic, clinical parameters as well as mortality and functional outcome were included in the analysis. RESULTS: 47 patients with ICH and 47 age- and hypertension matched controls were analyzed. ICH patients showed significantly lower total high frequency band (HF) and low frequency band (LF) powers (p = 0.01, p < 0.001), higher normalized HF power (p = 0.03), and lower LF/HF ratio (p < 0.001) as compared to the controls. Autonomic parameters showed associations with stroke severity (p = 0.004) and intraventricular involvement (p = 0.01) and predicted poor outcome independently (p = 0.02). CONCLUSIONS: Autonomic changes seems to be present in acute ICH and are associated with poor outcome independently. This may have future monitoring and therapeutic implications.

• MeSH
• autonomní nervový systém patofyziologie   MeSH
• cerebrální krvácení diagnóza   patofyziologie   MeSH
• cévní mozková příhoda patofyziologie   MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• prognóza MeSH
• senioři MeSH
• srdeční frekvence fyziologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

The negative impact of air incidents and emergency situations results from the leakage of liquids into the soil and water and the leakage of flue gases and combustion products of aircraft structural materials into the air during fires. This article deals with air pollution caused by the combustion of composite materials commonly used in general aviation. Samples of composite materials of aircraft registered in the Czech Republic were selected. These samples of composite materials were tested for flammability, according to ISO 5660-1:2002 Reaction to fire tests-Heat Release, smoke production and mass loss rate (ISO-International Organization for Standardization). Total smoke release and total oxygen consumed were assessed in this study, both of which have a significant impact on air quality in the case of an air incident. Based on the results of the research, differences resulting from the diversity of the structures of the tested composite materials were found. The most hazardous composite material was evaluated from the point of view of its impact on air quality during combustion.

• MeSH
• kouř analýza   MeSH
• látky znečišťující vzduch analýza   MeSH
• letadla * MeSH
• lidé MeSH
• nebezpečné látky analýza   MeSH
• plyny MeSH
• požáry * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH

DWI-FLAIR mismatch has been recently proven to identify patients with unknown onset stroke (UOS) eligible for thrombolysis. However, this concept may exclude patients from thrombolysis who may eventually benefit as well. We aimed to examine the feasibility, safety and potential efficacy of thrombolysis in wake-up stroke (WUS) and UOS patients using a modified DWI-FLAIR mismatch allowing for partial FLAIR positivity. WUS/UOS patients fulfilling the modified DWI-FLAIR mismatch and treated with intravenous thrombolysis (IVT) were compared to propensity score matched WUS/UOS patients excluded from IVT due to FLAIR positivity. The primary endpoint was a symptomatic intracranial hemorrhage (SICH), the secondary endpoints were improvement of ≥ 4 in NIHSS score and mRS score at 3 months. 64 IVT-treated patients (median NIHSS 9) and 64 controls (median NIHSS 8) entered the analysis (p = 0.2). No significant difference in SICH was found between the IVT group and the controls (3.1% vs. 1.6%, p = 0.9). An improvement of ≥ 4 NIHSS points was more frequent in IVT patients as compared to controls (40.6% vs. 18.8%, p = 0.01). 23.4% of IVT patients achieved a mRS score of 0-1 at 3 months as compared to 18.8% of the controls (p = 0.8). SICH, improvement of NIHSS ≥ 4 and mRS 0-1 at 3 months were comparable in thrombolyzed patients with negative FLAIR images versus those thrombolyzed with partial positive FLAIR images (3% vs. 3%, p = 0.9; 40% vs. 41%, p = 0.9; 19% vs. 22%, p = 0.8). Our study signalizes that thrombolysis may be feasible in selected WUS/UOS patients with partial FLAIR signal positivity.

• MeSH
• časové faktory MeSH
• cévní mozková příhoda diagnostické zobrazování   farmakoterapie   patofyziologie   MeSH
• difuzní magnetická rezonance * MeSH
• dospělí MeSH
• fibrinolytika aplikace a dávkování   škodlivé účinky   MeSH
• intrakraniální krvácení chemicky indukované   MeSH
• klinické rozhodování MeSH
• lidé středního věku MeSH
• lidé MeSH
• magnetická rezonanční angiografie MeSH
• mozková angiografie metody   MeSH
• mozkový krevní oběh MeSH
• obnova funkce MeSH
• posuzování pracovní neschopnosti MeSH
• prediktivní hodnota testů MeSH
• registrace MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• studie proveditelnosti MeSH
• trombolytická terapie škodlivé účinky   metody   MeSH
• výběr pacientů MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

BACKGROUND AND PURPOSE: Autonomic nervous system (ANS) seems to play an important role in the post-stroke immunosuppression syndrome with increased susceptibility to infections. The aim of this study was to investigate if ANS activity measured at admission is associated with post-stroke infections. METHODS: We prospectively analyzed patients with acute ischemic stroke. ANS was measured using the cross-correlational baroreflex sensitivity (BRS) at admission. The occurrence and cause of in-hospital infections was assessed based on the clinical and laboratory examination. Demographic and clinical variables including initial stroke severity, dysphagia, procedures as nasogastric tubes, central venous and urinary catheters and mechanical ventilation were included in the analysis. RESULTS: We included 161 patients with ischemic stroke, of those 49 (30.4%) developed a nosocomial infection during the first 7 days of hospital stay. Patients with infections had significantly lower BRS (median 3 vs 5 ms/mmHg, p < .001) higher initial NIHSS (median 15 vs 5, p < .001), had more often non-lacunar etiology and underwent more invasive procedures. In the multivariable regression model decreased BRS (adjusted OR 1.21, 95% CI 1.03-1.41, p = .02), admission NIHSS (adjusted OR 1.10, 95% CI 1.02-1.19, p = .02) and invasive procedures (adjusted OR 1.46, 95% CI 1.03-2.06, p = .03) were independently associated with infection after ischemic stroke. CONCLUSIONS: Decreased BRS was independently associated with infections after ischemic stroke. Autonomic shift may play an important role in increased susceptibility to infections after stroke. The possible diagnostic and therapeutic relevance of this finding deserves further research.

• MeSH
• baroreflex fyziologie   MeSH
• cévní mozková příhoda diagnóza   patofyziologie   MeSH
• dospělí MeSH
• infekce spojené se zdravotní péčí diagnóza   patofyziologie   MeSH
• ischemie mozku diagnóza   patofyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• prospektivní studie MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

The authors wish to make the following correction to their paper [...].

• Publikační typ
• tisková chyba MeSH

The purpose of this paper is to develop a fuzzy model of the risk assessment for environmental start-up projects in the air transport sector at the stage of business expansion. The model developed for the following software will be a useful tool for the risk decision support system of investment funds in financing environmental start-up projects at the stage of market conquest. Developing a quantitative risk assessment for environmental start-up projects for the air transport sector will increase the resilience of making risk decisions about their financing by the investors. In this paper, a set of 21 criteria for assessing the risk of launching environmental start-up projects in the air transport sector were formulated for the first time by presenting inputs in the form of a linguistic risk assessment and the number of credible expert considerations. The fuzzy risk assessment model, based on expert knowledge, uses linguistic variables, reveals the uncertainty of the input data, and displays a risk assessment with linguistic interpretation. The result of the paper is a fuzzy model that is embedded in a generalized algorithm and tested in an example risk assessment of environmental start-up projects in the air transport sector.

• MeSH
• fuzzy logika * MeSH
• hodnocení rizik * MeSH
• investice MeSH
• letectví * MeSH
• rozhodování MeSH
• software MeSH
• životní prostředí * MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

A simple method for the simultaneous derivatization of carbohydrates, polyols, amines and amino acids using hexamethyldisilazane and N,O-bis(trimethylsilyl)trifluoroacetamide was developed. This method allows the direct derivatization of urine samples without sample pretreatment before derivatization. The method was successfully used for analysis of the selected metabolites in urine samples of healthy individuals and neonates suffering from galactosemia. The limits of detection by positive chemical ionization gas chromatography with tandem mass spectrometry analysis were in the range of 1.0 mgL-1 for mannitol to 4.7 mg/L for glucose.

• MeSH
• algoritmy MeSH
• aminy moč   MeSH
• analýza moči MeSH
• dospělí MeSH
• galaktosemie moč   MeSH
• kalibrace MeSH
• lidé MeSH
• limita detekce MeSH
• novorozenec MeSH
• plynová chromatografie s hmotnostně spektrometrickou detekcí MeSH
• polymery analýza   MeSH
• reprodukovatelnost výsledků MeSH
• sacharidy moč   MeSH
• tandemová hmotnostní spektrometrie MeSH
• trimethylsilylové sloučeniny analýza   MeSH
• zmrazování MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• novorozenec MeSH
• Publikační typ
• časopisecké články MeSH

• MeSH
• Enterobacter genetika   metabolismus   MeSH
• inaktivátory komplementu MeSH
• komplement genetika   MeSH
• lidé MeSH
• nádory genetika   MeSH
• Paramecium caudatum genetika   metabolismus   MeSH
• přežití MeSH
• techniky in vitro MeSH
• Check Tag
• lidé MeSH

• MeSH
• experimentální nádory MeSH
• klinické laboratorní techniky MeSH
• klinické zkoušky jako téma MeSH
• lékařská onkologie MeSH
• Publikační typ
• sborníky MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Obory
• onkologie

• MeSH
• lékařství MeSH
• Publikační typ
• periodika MeSH

• Konspekt
• Lékařské vědy. Lékařství
• NLK Obory
• lékařství