Zymosan Dotaz Zobrazit nápovědu
- Klíčová slova
- STOBADINE,
- MeSH
- finanční podpora výzkumu jako téma MeSH
- indoly aplikace a dávkování farmakologie MeSH
- krevní buňky metabolismus účinky léků MeSH
- peroxidasa krev MeSH
- respirační vzplanutí účinky záření MeSH
- superoxidy chemie krev MeSH
- techniky in vitro MeSH
- volné radikály chemie krev MeSH
- zymosan aplikace a dávkování MeSH
- MeSH
- chemická stimulace MeSH
- experimentální sarkom farmakoterapie MeSH
- homologní transplantace MeSH
- krysa rodu rattus MeSH
- merkaptopurin terapeutické užití MeSH
- properdin biosyntéza MeSH
- sarkom Yoshidův farmakoterapie MeSH
- synergismus léků MeSH
- transplantace nádorů MeSH
- zvířata MeSH
- zymosan terapeutické užití MeSH
- Check Tag
- krysa rodu rattus MeSH
- ženské pohlaví MeSH
- zvířata MeSH
The idea of using killed microorganisms or their parts for a stimulation of immunity in the cancer immunotherapy is very old, but the question of interactions and binding of these preparations to tumor cells has not been addressed so far. The attachment of Zymosan A and both Gram-positive and Gram-negative bacteria to tumor cells was tested in in vivo experiments. This binding was accomplished by charge interactions, anchoring based on hydrophobic chains and covalent bonds and proved to be crucial for a strong immunotherapeutic effect. The establishment of conditions for simultaneous stimulation of both Toll-like and phagocytic receptors led to very strong synergy. It resulted in tumor shrinkage and its temporary or permanent elimination. The role of neutrophils in cancer immunotherapy was demonstrated and the mechanism of their action (frustrated phagocytosis) was proposed. Finally, therapeutic approaches applicable for safe human cancer immunotherapy are discussed. Heat killed Mycobacterium tuberculosis covalently attached to tumor cells seems to be promising tool for this therapy.
- MeSH
- buňky NK imunologie MeSH
- fagocytóza MeSH
- imunita MeSH
- imunomodulace MeSH
- imunoterapie metody MeSH
- lidé MeSH
- Listeria monocytogenes chemie imunologie MeSH
- melanom experimentální MeSH
- melanom imunologie terapie MeSH
- Mycobacterium tuberculosis chemie imunologie MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- nádory kůže imunologie terapie MeSH
- neutrofily imunologie MeSH
- protinádorové látky terapeutické užití MeSH
- transplantace nádorů MeSH
- tumor burden MeSH
- vysoká teplota MeSH
- zvířata MeSH
- zymosan chemie terapeutické užití MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
