regulative development Dotaz Zobrazit nápovědu

Přesná shoda Sémantické

The fibroblast growth factors (FGFs) constitute one of the largest growth factor families, and several ligands and receptors in this family are known to play critical roles during tongue development. In order to provide a comprehensive foundation for research into the role of FGFs during the process of tongue formation, we measured the transcript levels by quantitative PCR and mapped the expression patterns by in situ hybridization of all 22 Fgfs during mouse tongue development between embryonic days (E) 11.5 and E14.5. During this period, Fgf5, Fgf6, Fgf7, Fgf9, Fgf10, Fgf13, Fgf15, Fgf16 and Fgf18 could all be detected with various intensities in the mesenchyme, whereas Fgf1 and Fgf2 were expressed in both the epithelium and the mesenchyme. Our results indicate that FGF signaling regulates tongue development at multiple stages.

MeSH
embryo savčí metabolismus MeSH
embryonální vývoj genetika MeSH
epitel růst a vývoj metabolismus MeSH
fibroblastové růstové faktory biosyntéza genetika MeSH
hybridizace in situ MeSH
jazyk růst a vývoj metabolismus MeSH
mezoderm růst a vývoj metabolismus MeSH
myši MeSH
organogeneze genetika MeSH
signální transdukce MeSH
vývojová regulace genové exprese genetika MeSH
zvířata MeSH
Check Tag
myši MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH

Kniha

The Development of emotion regulation : biological and behavioral considerations

... present a broad overview of recent work on emotion conceived as a response that is both regulatory and regulated ...

Chicago : University of Chicago, 1994

Monographs of the Society for Research in Child Development ; Vol. 59

VIII, 308 s.

Článek online

The neglected part of early embryonic development: maternal protein degradation

... Nevertheless, the most important period seems to take place even before preimplantation development-during ...

Cellular and molecular life sciences. 2020 ; 77 (16) : 3177-3194. [pub] 20200224

Cell Mol Life Sci
ISSN 1420-9071
Medvik
Zdroj

The degradation of maternally provided molecules is a very important process during early embryogenesis. However, the vast majority of studies deals with mRNA degradation and protein degradation is only a very little explored process yet. The aim of this article was to summarize current knowledge about the protein degradation during embryogenesis of mammals. In addition to resuming of known data concerning mammalian embryogenesis, we tried to fill the gaps in knowledge by comparison with facts known about protein degradation in early embryos of non-mammalian species. Maternal protein degradation seems to be driven by very strict rules in terms of specificity and timing. The degradation of some maternal proteins is certainly necessary for the normal course of embryonic genome activation (EGA) and several concrete proteins that need to be degraded before major EGA have been already found. Nevertheless, the most important period seems to take place even before preimplantation development-during oocyte maturation. The defects arisen during this period seems to be later irreparable.

MeSH
embryo nesavčí metabolismus fyziologie MeSH
embryo savčí metabolismus fyziologie MeSH
embryonální vývoj fyziologie MeSH
genom fyziologie MeSH
lidé MeSH
oocyty metabolismus fyziologie MeSH
proteiny metabolismus MeSH
vývojová regulace genové exprese fyziologie MeSH
zvířata MeSH
Check Tag
lidé MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH
přehledy MeSH

Článek online

RNA regulation and cancer development

... several consequential mutations in oncogenes or tumor suppressor genes are necessary for cancer development ...

Cancer letters. 2007 ; 246 (1-2) : 12-23.

ISSN 0304-3835
Medvik
Zdroj

Cancer is viewed as a genetic disease. According to the currently accepted model of carcinogenesis, several consequential mutations in oncogenes or tumor suppressor genes are necessary for cancer development. In this model, mutated DNA sequence is transcribed to mRNA that is finally translated into functionally aberrant protein. mRNA is viewed solely as an intermediate between DNA (with 'coding' potential) and protein (with 'executive' function). However, recent findings suggest that (m)RNA is actively regulated by a variety of processes including nonsense-mediated decay, alternative splicing, RNA editing or RNA interference. Moreover, RNA molecules can regulate a variety of cellular functions through interactions with RNA, DNA as well as protein molecules. Although, the precise contribution of RNA molecules by themselves and RNA-regulated processes on cancer development is currently unknown, recent data suggest their important role in carcinogenesis. Here, we summarize recent knowledge on RNA-related processes and discuss their potential role in cancer development.