INTRODUCTION: Most patients with idiopathic pulmonary fibrosis (IPF) treated with antifibrotics (AF) have progressive disease despite treatment. A switch of AF may improve survival, but evidence from randomised controlled trials is missing. We aimed to evaluate the efficacy of an AF switch on survival and FVC decline in patients from the European MultiPartner IPF registry (EMPIRE). METHODS: The study included 612 patients who discontinued the first antifibrotic therapy. Patients were grouped and analysed from two perspectives: (1) whether they had received a second antifibrotic treatment after the discontinuation of the first therapy, and (2) a reason for discontinuation of the first AF - "lack of efficacy" (LE) and "intolerance" (INT). RESULTS: While 263 (43%) of 612 patients received no second AF ("non-switched"), 349 (57%) patients switched. Overall survival was higher in patients who received a second AF (median 50 vs. 29 months; adjusted HR 0.64, P=0.023). Similarly, the annual FVC decline was significantly reduced in switched patients: -98ml/y in switched and -172ml/y in non-switched patients (P=0.023), respectively. The switched patients had similar risk for mortality in both LE and INT groups (adjusted HR 0.95, P=0.85). The high impact of switching on survival was demonstrated in LE patients (adjusted HR 0.27, P<0.001). CONCLUSION: The patients without a second AF had significantly shorter overall survival. Our analysis suggests the importance of switching patients with an ineffective first AF therapy to a second AF therapy.
Oficiální webové portály jsou důležitou komponentou informačního zázemí screeningových programů zhoubných nádorů. Poskytují aktuální a relevantní informace jak odborným pracovníkům ve zdravotnictví, tak i široké veřejnosti a zájemcům o preventivní vyšetření. Slouží také jako oficiální médium pro publikaci výsledků jednotlivých programů. České národní screeningové programy jsou prezentovány na adresách www.mamo.cz (screening karcinomu prsu), www.kolorektum.cz (screening kolorektálního karcinomu) a www.cervix.cz (screening karcinomu hrdla děložního).
Official web portals are an important component of the background information of the cancer screening programmes. They provide up‑to‑date and relevant information for health care professionals, the general public and those interested in preventive examinations. They also serve as an official medium for publication of individual programme outcomes. The Czech national screening programmes are presented at the following websites: www.mamo.cz (breast cancer screening), www.kolorektum.cz (colorectal cancer screening), and www.cervix.cz (cervical cancer screening). Key words: screening – prevention – information – website – public This study was supported by the project 36/14//NAP “Development and implementation of methodology for the evaluation of effectiveness of personalised invitations of citizens to cancer screening programmes” as part of the programme of the Czech Ministry of Health “National action plans and conceptions”. The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers. Submitted: 23. 9. 2014 Accepted: 29. 10. 2014
- MeSH
- informační služby * MeSH
- internet * MeSH
- kolorektální nádory prevence a kontrola MeSH
- lidé MeSH
- nádory děložního čípku prevence a kontrola MeSH
- nádory prsu prevence a kontrola MeSH
- on-line systémy MeSH
- plošný screening * MeSH
- podpora zdraví metody MeSH
- šíření informací MeSH
- sociální média MeSH
- zdravotnická komunikace * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
Propagace screeningových programů zhoubných nádorů a poskytnutí správných a úplných informací směrem k široké veřejnosti jsou naprosto nezbytnou podmínkou k tomu, aby bylo dosaženo dostatečné účasti a tyto programy mohly plnit svou dlouhodobou funkci. Významnou roli v této oblasti hrají různé neziskové organizace a občanská sdružení. Článek přináší přehled nejviditelnějších aktivit a kampaní, které pomáhají při informování veřejnosti o možnostech prevence nádorových onemocnění a preventivních vyšetřeních v ČR.
Promotion of cancer screening programmes and provision of correct and comprehensive information to the general public are essential for achieving sufficient attendance at the programmes and fulfilling their long‑term function. Various NGOs and CSOs play a very important role in this field. The article provides an overview of the most visible activities and campaigns that spread information about cancer prevention and preventive examinations in the Czech Republic. Key words: civil society organisation – health campaigns – prevention – screening This study was supported by the project 36/14//NAP “Development and implementation of methodology for the evaluation of effectiveness of personalised invitations of citizens to cancer screening programmes” as part of the programme of the Czech Ministry of Health “National action plans and conceptions”. The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers. Submitted: 9. 9. 2014 Accepted: 30. 10. 2014
- Klíčová slova
- propagace zdraví,
- MeSH
- adherence pacienta MeSH
- kolorektální nádory prevence a kontrola MeSH
- lidé MeSH
- motivace MeSH
- nádory prsu prevence a kontrola MeSH
- nádory * prevence a kontrola MeSH
- neziskové organizace * MeSH
- plošný screening MeSH
- podpora zdraví * MeSH
- spolupráce organizací a občanů * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
Number seven is considered to be lucky and magic; it is even a “lucky number” in a mathematical concept that was defined in the 1950s. Although the degree of personal happiness and enchantment of participants in the 7th year of the MEFANET conference inevitably varied, the network of Czech and Slovak medical faculties has undoubtedly won favour with all of them.
In vivo fluorescence methods have been accepted as a quick, simple, and useful tool for quantification of phytoplankton organisms. In this paper, we present a case study in which fluorescence methods were employed for the selective detection of potentially toxic cyanobacteria in raw water at the drinking water treatment plant. The occurrence of cyanobacteria in the drinking water reservoir and in raw water was monitored by phycocyanin fluorescence measurements and by standard methods for phytoplankton quantification (cell counts, chlorophyll a). A special attention was paid to the most critical parts of the season -- spring recruitment of cyanobacteria from sediment to water column and autumn bloom collapse. All methods showed similar patterns within the season. Phycocyanin fluorescence was found to be a simple and sensitive indicator of cyanobacteria in water and can serve as a tool that can provide an early warning about the presence of potentially toxic cyanobacterial metabolites in water.
