Background: Femoroacetabular impingement syndrome (FAI) is a complex, often post-traumatically developing impairment of the hip joint. It is characterized by ambiguous symptomatology, which makes early diagnosis difficult. Aim: The study was conducted to evaluate the applicability of a triaxial gyroscopic sensor in routine practice as an additional indication criterion for operative versus conservative treatment procedures. Methods: Ninety-two patients were included in the experimental retrospective study and 62 completed the examination. All patients signed informed consent. A gyroscopic sensor was placed on the right side of the pelvis above the hip joint and patients walked approximately 15 steps. Data were also evaluated while the patients climbed stairs. A complete clinical examination of the dynamics and physiological movements in the joint was performed. The data measured by the gyroscopic sensor were processed using differential geometry methods and subsequently evaluated using spectral analysis and neural networks. Results: FAI diagnosis using gyroscopic measurement is fast and easy to implement. Our approach to processing the gyroscopic signals used to detect the stage of osteoarthritis and post-traumatic FAI could lead to more accurate detection and capture early in FAI development. Conclusions: The obtained data are easily evaluated, interpretable, and beneficial in the diagnosis of the early stages of FAI. The results of the study show that this approach can lead to more accurate and early detection of osteoarthritis and post-traumatic FAI.
- MeSH
- analýza chůze metody MeSH
- biomechanika * MeSH
- femoroacetabulární impingement * chirurgie diagnóza patofyziologie MeSH
- kyčelní kloub patofyziologie MeSH
- lidé MeSH
- nositelná elektronika * MeSH
- osteoartróza diagnóza patofyziologie MeSH
- retrospektivní studie MeSH
- telemedicína metody MeSH
- umělá inteligence MeSH
- Check Tag
- lidé MeSH
PURPOSE OF THE STUDY Femoroacetabular impingement syndrome is a complex, often post-traumatically developing impairment of the hip joint, characterized by ambiguous symptomatology, which makes early diagnosis diffi cult, especially in the early stages. Experimental retrospective study was carried out to evaluate the usability of a triaxial gyroscopic sensor in routine practice as an additional indication criterion for operative versus conservative treatment procedures. MATERIAL AND METHODS 92 patients were included in the retrospective study, and 62 completed the investigation. All patients signed informed consent. A gyroscopic sensor was placed on the right side of the pelvis above the hip joint, and the patients walked approximately 15 steps. Furthermore, an evaluation of the data during stair climbing and a complete clinical examination of the dynamics and physiological movements in the joint was carried out. Data measured with a gyroscopic sensor were processed using differential geometry methods and then evaluated using spectral analysis and neural networks. The proposed technique of diagnosing FAI using gyroscope measurement is a fast, easy-to-perform method. RESULTS Our approach in processing gyroscopic signals used to detect the stage of arthrosis and post-traumatically developing FAI could lead to more accurate early detection and capture in the early stages. CONCLUSIONS The obtained data are easily evaluated, interpretable and benefi cial in diagnosing the early stages of FAI. The results of the conducted research showed this approach to more accurate early detection of arthrosis and post-traumatically developing FAI. Key words: wearable sensors; osteoarthritis; mathematical biophysics; telemedicine.
Doporučené diagnostické a terapeutické postupy pro všeobecné praktické lékaře
29 stran ; 30 cm
Příručka a směrnice, které se zaměřují na klinické laboratorní diagnostické metody. Určeno odborné veřejnosti, praktickým lékařům.
- MeSH
- klinické laboratorní techniky MeSH
- praktické lékařství MeSH
- Publikační typ
- příručky MeSH
- směrnice pro lékařskou praxi MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- diagnostika
- všeobecné lékařství
- NLK Publikační typ
- brožury
Závěrečná zpráva o řešení grantu Agentury pro zdravotnický výzkum MZ ČR
nestr.
In the early years after menopause, women have an increased risk for osteoporosis and rheumatoid arthritis. The aim of this study is to test our hypothesis that estrogen deficiency after menopause affects the gut microbiome, and that deterioration of gut barrier contributes to the development of chronic inflammation and its consequences, increased risk of osteoporosis and rheumatoid arthritis. Hormone therapy in postmenopausal women may adjust the intestinal barrier and thus affect the speed and degree of bone loss, but also progression of rheumatoid arthritis disease activity score of this serious disease. The study will contribute to the evaluation of markers of the intestinal barrier disorders, their association with chronic inflammation, their use in screening and identification of women at increased risk of osteoporosis and rheumatoid arthritis, and assessing the effectiveness of preventive measures in these diseases.
U žen v časném období po menopauze je vysoká incidence nástupu osteoporózy a revmatoidní artritidy. Studie má ověřit naši hypotézu, že deficience estrogenů po menopauze mění střevní mikrobiom, a že se změny střevní bariéry významně podílejí na rozvoji chronického zánětu při deficienci estrogenů a na jeho důsledcích, zvýšeném riziku osteoporózy a revmatoidní artritidy. Hormonální terapie může u žen po menopauze upravit funkci střevní bariéry a významně tak ovlivnit rychlost a stupeň úbytku kostní hmoty, ale také upravit skóre aktivity revmatoidní artritidy a progresi tohoto závažného onemocnění. Práce má přispět k hodnocení markerů poruchy střevní bariéry, jejich asociace s projevy chronického zánětu a jejich využití při screeningu a identifikaci žen se zvýšeným rizikem osteoporózy a revmatoidní artritidy a při posuzování účinnosti preventivních opatření při těchto onemocněních.
- Klíčová slova
- revmatoidní artritida, rheumatoid arthritis, střevní mikrobiom, gut microbiome, Osteoporóza, Chronický zánět, Osteoporosis, Chronic inflammation,
- NLK Publikační typ
- závěrečné zprávy o řešení grantu AZV MZ ČR
- Publikační typ
- abstrakt z konference MeSH
Postmenopausal osteoporosis (PMOP) therapies are frequently evaluated by bone mineral density (BMD) gains against patients receiving placebo (calcium and vitamin D supplementation, a mild bone turnover-suppressing intervention), which is not equivalent to either healthy or treatment-naive PMOP. The aim of the present observational study was to assess the effects of TPTD treatment in PMOP (20 μg, once daily) at 6 (TPTD 6m; n = 28, age 65 ± 7.3 years), and 24 (TPTD 24m; n = 32, age 67.4 ± 6.15 years) months on bone quality indices at actively forming trabecular surfaces (with fluorescent double labels). Data from the TPTD-treated PMOP patients were compared with those in healthy adult premenopausal women (HC; n = 62, age 40.5 ± 10.6 years), and PMOP receiving placebo (PMOP-PLC; n = 94, age 70.6 ± 4.5 years). Iliac crest biopsies were analyzed by Raman microspectroscopy at three distinct tissue ages: mid-distance between the second label and the bone surface, mid-distance between the two labels, and 1 μm behind the first label. Mineral to matrix ratio (MM), mineral maturity/crystallinity (MMC), tissue water (TW), glycosaminoglycan (GAGs), and pyridinoline (Pyd) content were determined. Outcomes were compared by ANCOVA with subject age and tissue age as covariates, and health status as a fixed factor, followed by Sidak's post-hoc testing (significance assigned to p < 0.05). Both TPTD groups increased MM compared to PMOP-PLC. While TPTD 6m had values similar to HC, TPTD 24m had higher values compared to either HC or TPTD 6m. Both TPTD groups had lower MMC values compared to PMOP-PLC and similar to HC. TPTD 6m patients had higher TW content compared to HC, while TPTD 24m had values similar to HC and lower than either PMOP-PLC or TPTD 6m. Both TPTD groups had lower GAG content compared to HC group, while TPTD 6m had higher values compared to PMOP-PLC. Finally, TPTD 6m patients had higher Pyd content compared to HC and lower compared to PMOP-PLC, while TPTD 24m had lower values compared to PMOP-PLC and TPTD 6m, and similar to HC group. The results of the present study indicate that effects of TPTD on forming trabecular bone quality indices depend on treatment duration. At the recommended length of 24 m, TPTD restores bone mineral and organic matrix quality indices (MMC, TW, Pyd content) to premenopausal healthy (HC) levels.
- MeSH
- dospělí MeSH
- inhibitory kostní resorpce * farmakologie terapeutické užití MeSH
- kostní denzita MeSH
- lidé středního věku MeSH
- lidé MeSH
- os ilium patologie MeSH
- postmenopauzální osteoporóza * farmakoterapie patologie MeSH
- senioři MeSH
- teriparatid farmakologie terapeutické užití MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- práce podpořená grantem MeSH
Osteoarthritis is the most common type of degenerative joint disease and affects millions of people. In this paper, we propose a non-obtrusive and straightforward method to assess the progression of osteoarthritis. In standard medicine praxis, osteoarthritis is observed with X-rays. In this study, we use widely available wearable sensors with gyroscopes to make the observation. Two novel methods are proposed for gyroscope data processing. A small-scale study has shown that these methods can be used to monitor osteoarthritis's progression, and to differentiate between healthy subjects and subjects with femoroacetabular impingement syndrome.
- MeSH
- artroskopie metody MeSH
- artróza kyčelních kloubů * diagnostické zobrazování MeSH
- femoroacetabulární impingement * diagnostické zobrazování MeSH
- kyčelní kloub MeSH
- lidé MeSH
- osteoartróza * diagnostické zobrazování MeSH
- rentgendiagnostika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Publikační typ
- abstrakt z konference MeSH
- MeSH
- dietoterapie metody MeSH
- lidé MeSH
- osteoporóza * prevence a kontrola MeSH
- pohybová aktivita MeSH
- stárnutí MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- antirevmatika terapeutické užití MeSH
- bolesti zad farmakoterapie MeSH
- dospělí MeSH
- kolagen aplikace a dávkování MeSH
- kosterní svaly patologie MeSH
- lidé MeSH
- mikrotrauma diagnóza farmakoterapie terapie MeSH
- stehno patologie MeSH
- terapie neúspěšná MeSH
- třísla patologie MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
