Background: Although epidemiologic data are scarce, there is no doubt that the increase in pollen allergies is going to be followed by an increase in the so-called pollen-related food allergies. The aim of this study was the evaluation of the food hypersensitivity reactions in atopic dermatitis patients and the relation to the sensitization to grass and trees. Methods: The complete dermatological and allergological examinations were performed in all included patients; the occurrence of food hypersensitivity reactions was recorded and the sensitization to inhalant allergens (grass and trees) was examined (skin prick test, and specific IgE). The statistical evaluation of the relation between the sensitization to these inhalant allergens and the occurrence of food hypersensitivity reactions was performed. Results: A total of 321 patients were included, with an average age of 26.7 years (±9.2 years) and with an average SCORAD of 33.2 (±13.3) points. The significant relation was recorded between the patients suffering from sensitization to grass and the reactions to peanuts, celery and walnuts; another significant relation was demonstrated between the patients suffering from sensitization to trees and reactions to apple, peanuts, and walnuts. In patients suffering from sensitization to grass and trees, the occurrence of food hypersensitivity reactions to tomatoes, kiwi, spices, oranges, capsicum, tangerines, and carrot was higher also, but the relation was not significant. Conclusion: The significant relation was found between the reactions to peanuts and walnuts and sensitization to grass and trees, another significant relation was found between the sensitization to grass and celery and between the sensitization to trees and apple.
- Publikační typ
- časopisecké články MeSH
Background: Eosinophils play an important pathogenic role in atopic dermatitis (AD), but its exact function remains to be determined. Aims and Objectives: The aim of this study was to correlate the eosinophil count with the manifestations such as asthma bronchiale, rhinitis, level of total IgE, sensitization to mites, animal dander, bird feather, dust, mixture of grass, mixture of trees, mixture of fungi, duration of lesions (persistent or occasional during last year), family history about atopy, and onset of AD (under or above 5 year of age). Materials and Methods: Two hundred and seventy-two patients suffering from AD at the age of 14 year or older were examined - 100 men and 172 women with the average age of 26.7±9.5 years and with the average SCORAD index of 32.9±14.1. Complete dermatological and allergological examinations were performed in all patients with the evaluation of monitored manifestations. Mann-Whitney test for difference in medians was used for statistical evaluation. Results: The count of eosinophils in peripheral blood was significantly higher in patients with total IgE ≥200 IU/ml, with sensitization to dust, with persistent eczematous lesions and in patients with the onset of AD under 5 year of age. The count of eosinophils above 5% was recorded as well in patients suffering from asthma bronchiale, rhinitis, sensitization to mites, and in patients with positive family history about atopy, but the difference was not significant. On the other hand, the count of eosinophils was under 5% in patients with sensitization to animal dander, bird feather, mixture of grass and trees. Conclusion: Our results demonstrated the difference in the count of eosinophils in peripheral blood according to different manifestations in patients suffering from AD.
- Publikační typ
- časopisecké články MeSH
Background: Fungi as a source of allergen are still largely neglected in basic research as well as in clinical practice. This study aimed to highlight the impact of fungal allergens in a group of patients suffering from atopic dermatitis (AD). Aims and Objectives: The evaluation of the sensitization to fungi in AD patients aged 14 year and older and the evaluation of the relation of fungal sensitization to the occurrence of other atopic diseases and parameters. Materials and Methods: All patients satisfying inclusion criteria attending our hospital between 2008 and 2017 were included in the study. The complete dermatological and allergological examinations were performed in all included patients including examination of specific immunoglobulin E, skin prick test to mixture of fungi and inhalant allergens, evaluation of asthma bronchiale, rhinitis, onset of AD, family history about atopy, duration of eczematous lesions, severity of AD. Pairs of these categories were entered in the contingency tables and the Chi-square test for relationship of these variables was performed with the level of significance set below 5%. Results: Three hundred and thirty-one patients were included in the study; the average age was 26.8 years. The sensitization to fungi was recorded in 100 patients (30%). In these patients, the occurrence of asthma bronchiale, rhinitis, family history about atopy, sensitization to grass and trees was significantly higher than in patients without sensitization to fungi. We did not find any significant relation between the sensitization to fungi and the severity of AD, no relation was also found between the sensitization to fungi and sensitization to mites, animal dander, bird feather, and dust. Conclusion: The occurrence of asthma bronchiale, rhinitis, family history about atopy, sensitization to grass and trees was significantly higher in AD patients with sensitization to fungi. No relation was found between the severity of AD and the sensitization to fungi.
- Publikační typ
- časopisecké články MeSH
Background: In adult patients suffering from atopic dermatitis (AD), studies investigating the co-prevalence of AD and food allergy are still scarce, and exact data are not available. Aims and Objectives: To evaluate the occurrence of food allergy to peanuts in significant relation to food hypersensitivity, inhalant allergy and to asthma bronchial and rhinitis. Materials and Methods: Altogether 332 patients of AD 14 year or older were included in the study. The complete dermatological and allergological examinations were performed in all included patients (including examination of specific immunoglobulin E, skin prick test to different food and inhalant allergens, anamnestic data about food reactions, evaluation of allergic rhinitis, and allergic asthma bronchiale). We evaluated whether there was some relation between the food allergy to peanuts and followed parameters. Pairs of these categories were entered in the contingency tables, and the Chi-square test for the relationship of these variables was performed with the level of significance set to 5%. Results: Altogether 332 persons suffering from AD were included in the study of which 120 were male and 212 were female; the average age was 27.2 year. The significant relation between the allergy to peanuts and the occurrence of food hypersensitivity (FH) reactions to tomatoes, kiwi, apples, oranges, carrot and to the sensitization to grass, trees, mites, and the occurrence of rhinitis was found. Conclusion: The significant relation between the allergy to peanuts and the occurrence of FH reactions and the sensitization to inhalant allergens and rhinitis was found. The future studies may show if the decrease in food allergy to peanuts can lead to the decrease of the occurrence of other FH reactions and sensitization to inhalant allergens and rhinitis in AD patients.
- Publikační typ
- časopisecké články MeSH
The aim of this study is the evaluation of the relation between the sensitisation to outdoor and indoor fungi and allergy to peanuts and walnuts in atopic dermatitis patients aged 14 years and older. The complete dermatological and allergological examinations were performed in all included patients; the occurrence of food allergy to peanuts and walnuts was recorded (specific IgE, skin prick test, history of allergic reaction) and the sensitisation to mixture of outdoor fungi and indoor fungi was also examined (skin prick test, specific IgE). The statistical evaluation of the relation between the sensitisation to outdoor and indoor fungi and the occurrence of food allergy to peanuts and walnuts was performed; 329 patients were included in the study, 110 men and 219 women, the average age 26.8 years. The sensitisation to outdoor fungi was recorded in 91 patients (28%), the sensitisation to indoor fungi was recorded in 61 patients (18.5%), the occurrence of food allergy to peanuts was confirmed in 90 (27%) patients and to walnuts in 121 (36.7%) patients. We confirmed, that patients suffering from sensitisation to outdoor fungi suffer significantly more from food allergy to peanuts and walnuts. The significant relation between the sensitisation to indoor fungi and food allergy to peanuts and walnuts was not confirmed.
- MeSH
- alergeny imunologie MeSH
- Arachis imunologie MeSH
- atopická dermatitida komplikace MeSH
- dospělí MeSH
- houby imunologie MeSH
- imunizace * MeSH
- imunoglobulin G krev MeSH
- Juglans imunologie MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- potravinová alergie komplikace MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Existuje pouze málo prací zabývajících se vztahem mezi IgE senzibilizací na inhalační alergeny u pacientů s atopickým ekzémem a dalšími projevy atopie. Cílem této studie je u pacientů s atopickým ekzémem zhodnocení závislosti mezi IgE senzibilizací na běžné inhalační alergeny a výskytem bronchiálního astmatu, alergické rýmy a dalších parametrů. U všech pacientů zahrnutých do studie byla vyšetřena senzibilizace na prach, roztoče, zvířecí srst a peří ptáků pomocí kožních prick testů a sérového IgE. Byla hodnocena závislost mezi senzibilizací na tyto inhalační alergeny a výskytem bronchiálního astmatu, alergické rýmy, trváním atopické dermatitidy, rodinnou anamnézou. Vyšetřili jsme 288 pacientů – 90 mužů a 198 žen. Při statistickém zpracování bylo prokázáno, že IgE senzibilizace na sledované inhalační alergeny zvyšuje riziko vzniku bronchiálního astmatu a alergické rýmy. U pacientů se senzibilizací na peří ptáků se vyskytuje významně častěji vznik atopického ekzému po 5. roce života a u těchto pacientů nebyla prokázána souvislost s výskytem pozitivní rodinné anamnézy. Klíčová slova: atopický ekzém – inhalační alergeny – prach – roztoči – srst zvířat – peří ptáků – bronchiální astma – rýma – začátek atopického ekzému – trvání ekzému – rodinná anamnéza
A few reports demonstrate the relationship between IgE sensitization to aeroallergens in atopic dermatitis and other allergic diseases and parameters. The objective of this study is to evaluate, if there is a significant relationship between the sensitization to common aeroallergens in atopic dermatitis patients and the occurrence of asthma bronchiale, rhinitis, and other atopic parameters. Sensitization to dust, mites, animal dander, and bird feather was examined byskin prick test and specific IgE. The relationship of sensitization to these allergens and the occurrence of asthma bronchiale, rhinitis, duration of atopic dermatitis, family history, and onset of atopic dermatitis was evaluated. We examined 288 patients – 90 men and 198 women. According to our results, IgE sensitisation to animal dander, dust and mites may increase the risk of developing asthma or rhinitis. In patients with sensitization on the feathers of birds occurs significantly more frequently the onset of atopic eczema after the 5th year of life and in these patients no relationship to the positive family history of atopy has been found. Key words: atopic dermatitis – inhalant allergy – mites – dust – animal dander – feather – asthma bronchiale – rhinitis – onset of atopic dermatitis – duration of eczema – family history
- MeSH
- alergická rýma MeSH
- alergie diagnóza imunologie klasifikace MeSH
- atopická dermatitida * imunologie MeSH
- bronchiální astma imunologie MeSH
- dospělí MeSH
- imunizace MeSH
- imunoglobulin E * diagnostické užití imunologie MeSH
- kožní testy * využití MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- náplasťové testy využití MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
BACKGROUND: A few reports demonstrate the occurrence of egg allergy in adolescent and adult patients suffering from atopic dermatitis and the association of this allergy to other food and aeroallergens. AIMS AND OBJECTIVES: The aim of this study is to evaluate the occurrence of egg allergy in patients suffering from atopic dermatitis at the age 14 years and older and to evaluate the relationship between egg allergy or egg sensitisation and the sensitisation to dust, mites, feather, and animal dander. MATERIALS AND METHODS: Complete dermatological and allergological examination was performed. These parameters were examined: food allergy and food sensitisation to egg white and yolk, to mites, animal dander (mixture), feather and dust. The statistical evaluation of the relations among egg allergy, egg sensitisation and sensitisation to mites, animal dander (mixture), feather and dust was performed. Two hundred and eighty eight patients were included in the study (90 men, 198 women, with the average age 25.2). RESULTS AND CONCLUSION: Egg allergy was recorded in 5% and egg sensitisation in 20% of patients; sensitisation to dust is recorded more often in patients with positive results in sIgE for egg white and/or yolk.
- MeSH
- alergie na vejce komplikace imunologie MeSH
- alergie komplikace MeSH
- atopická dermatitida komplikace imunologie MeSH
- dospělí MeSH
- lidé MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Klíčová slova
- potravinové aditivum, nealergická hypersenzitivita,
- MeSH
- alergie * diagnóza etiologie imunologie prevence a kontrola terapie MeSH
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- poruchy chování u dětí * dietoterapie etiologie prevence a kontrola MeSH
- potravinářská barviva aplikace a dávkování klasifikace normy škodlivé účinky MeSH
- potravinářské konzervační látky aplikace a dávkování klasifikace škodlivé účinky MeSH
- potravinářské přísady * aplikace a dávkování klasifikace normy škodlivé účinky MeSH
- potravinová alergie diagnóza etiologie imunologie prevence a kontrola MeSH
- předškolní dítě MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- předškolní dítě MeSH
UNLABELLED: Aim of our study was to evaluate the importance of atopy patch testing with aeroallergens as a diagnostic method in patients suffering from atopic dermatitis. METHOD: The complet dermatological and allergological examinations were performed in 29 patients; 10 men, 19 women with the average age of 27.8 years, min. 17, max. 57 years; with the median SCORAD 24.2 points, s.d. 13.3 points. Wormwood, grass, dog dander, cat dander, dermatophagoides pharinae, dermatophagoides pteronyssinus and birch pollen were examined in diagnostic procedures. Skin prick tests, specific IgE were examined; the atopy patch tests were performed with aeroallergens for skin prick tests in concentration 1 x skin prick tests. RESULTS: Specific IgE and skin prick tests to one or more tested aeroallergens were positive altogether in 27 patients; atopy patch tests were positive only in one of these patients. CONCLUSION: For atopy patch testing with aeroallergens the concentration of 1 x skin prick tests is low to confirme the eczematic reaction in patients suffering from allergy to inhallant allergens.
- MeSH
- alergeny * MeSH
- antigeny roztočů domácího prachu * MeSH
- atopická dermatitida diagnóza etiologie MeSH
- dospělí MeSH
- kočky MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- náplasťové testy * MeSH
- psi MeSH
- pyl * MeSH
- zvířata MeSH
- zvířecí forma lupů * MeSH
- Check Tag
- dospělí MeSH
- kočky MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- psi MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky kontrolované MeSH
