The consequence of the massive increase in population in recent years is the enormous production of mainly industrial waste. The effort to minimize these waste products is, therefore, no longer sufficient. Biotechnologists, therefore, started looking for ways to not only reuse these waste products, but also to valorise them. This work focuses on the biotechnological use and processing of waste oils/fats and waste glycerol by carotenogenic yeasts of the genus Rhodotorula and Sporidiobolus. The results of this work show that the selected yeast strains are able to process waste glycerol as well as some oils and fats in a circular economy model and, moreover, are resistant to potential antimicrobial compounds present in the medium. The best-growing strains, Rhodotorula toruloides CCY 062-002-004 and Rhodotorula kratochvilovae CCY 020-002-026, were selected for fed-batch cultivation in a laboratory bioreactor in a medium containing a mixture of coffee oil and waste glycerol. The results show that both strains were able to produce more than 18 g of biomass per litre of media with a high content of carotenoids (10.757 ± 1.007 mg/g of CDW in R. kratochvilovae and 10.514 ± 1.520 mg/g of CDW in R. toruloides, respectively). The overall results prove that combining different waste substrates is a promising option for producing yeast biomass enriched with carotenoids, lipids, and beta-glucans.
- Publication type
- Journal Article MeSH
BACKGROUND: Coronary heart disease (CHD) mortality has declined substantially in the Czech Republic over the last two decades. DESIGN: The purpose of this study was to determine what proportion of this CHD mortality decline could be associated with temporal trends in major CHD risk factors and what proportion with advances in medical and surgical treatments. METHODS: The validated IMPACT mortality model was used to combine and analyse data on uptake and effectiveness of CHD management and risk factor trends in the Czech Republic in adults aged 25-74 years between 1985 and 2007. The main sources were official statistics, national quality of care registries, published trials and meta-analyses, and the Czech MONICA and Czech post-MONICA studies. RESULTS: Between 1985 and 2007, age-adjusted CHD mortality rates in the Czech Republic decreased by 66.2% in men and 65.4% in women in the age group 25-74 years, representing 12,080 fewer CHD deaths in 2007. Changes in CHD risk factors explained approximately 52% of the total mortality decrease, and improvements in medical treatments approximately 43%. Increases in body mass index and in diabetes prevalence had a negative impact, increasing CHD mortality by approximately 1% and 5%, respectively. CONCLUSIONS: More than half of the very substantial fall in CHD mortality in the Czech Republic between 1985 and 2007 was attributable to reduction in major cardiovascular risk factors. Improvement in treatments accounted for approximately 43% of the total mortality decrease. These findings emphasize the value of primary prevention and evidence-based medical treatment.
- MeSH
- Adult MeSH
- Coronary Disease mortality MeSH
- Middle Aged MeSH
- Humans MeSH
- Risk Factors MeSH
- Aged MeSH
- Sensitivity and Specificity MeSH
- Models, Statistical MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
10 stran : portrét ; 21 cm
- MeSH
- Academies and Institutes MeSH
- Electronic Health Records MeSH
- Integrated Advanced Information Management Systems MeSH
- Registries MeSH
- Public Health Informatics MeSH
- Health Information Systems MeSH
- Publication type
- Review MeSH
- Conspectus
- Informační věda
- NML Fields
- lékařská informatika
- veřejné zdravotnictví
23 stran : ilustrace ; 21 cm
- MeSH
- Academies and Institutes economics organization & administration legislation & jurisprudence MeSH
- Information Systems MeSH
- International Cooperation MeSH
- Public Health Informatics MeSH
- Health Care Evaluation Mechanisms statistics & numerical data MeSH
- Publication type
- Annual Report MeSH
- Conspectus
- Veřejné zdraví a hygiena
- NML Fields
- management, organizace a řízení zdravotnictví
- lékařská informatika
Background: Coronary heart disease (CHD) mortality has declined substantially in the Czech Republic over the last two decades. Design: The purpose of this study was to determine what proportion of this CHD mortality decline could be associated with temporal trends in major CHD risk factors and what proportion with advances in medical and surgical treatments. Methods: The validated IMPACT mortality model was used to combine and analyze data on uptake and effectiveness of CHD management and risk factor trends in the Czech Republic in adults aged 25–74 years between 1985 and 2007. The main sources were official statistics, national quality of care registries, published trials and meta-analyses, and the Czech MONICA and post-MONICA studies. Results: Between 1985 and 2007, age-adjusted CHD mortality rates in the Czech Republic decreased, representing in the age group 25–74 years 12,080 fewer CHD deaths in 2007. Changes in CHD risk factors explained approximately 52% of the total mortality decrease, improvements in medical treatments approximately 43%. Conclusions: More than half of the fall in CHD mortality in the Czech Republic between 1985 and 2007 was attributable to reduction in major cardiovascular risk factors. These findings emphasize the value of primary and secondary prevention.
- MeSH
- Adult MeSH
- Coronary Disease * mortality MeSH
- Middle Aged MeSH
- Humans MeSH
- Mortality * trends MeSH
- Risk Factors MeSH
- Aged MeSH
- Statistics as Topic MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Geographicals
- Czech Republic MeSH
Závěrečná zpráva o řešení grantu Interní grantové agentury MZ ČR
Přeruš. str. : il., tab. ; 31 cm
In this project we will study the role of folates in pathogenesis of metabolic syndrome-an important and frequent risk factor for arteriosclerosis- by using rodent models and by examining a patient and control cohort established in 1997-1999. In the rodent models we will analyze mutations in the Folr1 gene and their impact on gene expression and metabolism of folates. Furthermore we will test whether changes in folate intake will result in alterations of blood pressure and insulin resistance. We will genotype selected variants in archived human DNA samples of a cohort and in a subset also sequence the FOLR1 gene; the subsequent association analysis will reveal the role of these genetic variants in the development of metabolic syndrome. In a prospectivestudy we will obtain morbidity and mortality data from registry and subsequently analyze whether genetic variants strongly associated with metabolic syndrome are manifesting by clinically relevant disorders of the cardiovascular system.
V projektu budeme studovat úlohu folátů při vzniku metabolického syndromu, velmi důležitého a častého risikového faktoru pro vznik atherosklerosy, jednak na potkaních modelech metabolického syndromu a dále v souboru pacientů a kontrol z let 1997-1999. Upotkanů budeme analysovat mutace v genu Folr1 a zjistíme jejich dopady na expresi genu a na metabolismus folátů, dále ověříme, zda změny v dietním přívodu folátů budou doprovázeny odpovídajícími změnami v krevním tlaku a insulinové resistenci. U osob z kohorty doplníme v archivních vzorcích DNA genotypy ve vybraných lokusech a u části osob budeme sekvenovat i gen FOLR1; v následné asociační analyse zjistíme úlohu genetických variant při vzniku metabolického syndromu. V prospektivní studii zjistíme příčiny hospitalisací a úmrtí a následnou analysou ověříme, zda se genetické varianty silně asociované s metabolickým syndromem projevují i klinicky relevantním způsobem v onemocněních kardiovaskulárního systému.
- MeSH
- Folate Receptors, GPI-Anchored MeSH
- Folate Receptor 1 MeSH
- Genetic Variation MeSH
- Homocysteine MeSH
- Insulin Resistance MeSH
- Folic Acid analogs & derivatives MeSH
- Metabolic Syndrome etiology MeSH
- Rats, Inbred SHR MeSH
- Prospective Studies MeSH
- Conspectus
- Patologie. Klinická medicína
- NML Fields
- vnitřní lékařství
- NML Publication type
- závěrečné zprávy o řešení grantu IGA MZ ČR
Úmrtnost na CHOPN byla posouzena v absolutních počtech, relativních na 100 000 obyvatel a na 100 000 obyvatel (evropský standard) na podkladě údajů národního registru úmrtí. Zvýšení úmrtnosti na CHOPN byla v letech 2008/2009 následující: absolutní počet u mužů 1275/1448 (+14 %), u žen 821/886 (+8 %), N/100 000 u mužů 24,9/28,1 (+13 %), u žen 15,4/16,6 (+8 %), N/100 000 (evropský standard) u mužů 23,0/25,5 (+11 %), u žen 9,2/9,6 (+4 %). Počty případů úmrtí na diagnózu J44 představovaly 90 % všech úmrtí na diagnózy s kódy J40-J44. Mortalita na CHOPN byla v r. 2009 v ČR na 6. místě v pořadí mezi příčinami úmrtí za ischemickou chorobou srdeční, cerebrovaskulárními nemocemi, rakovinou a pneumonií. Mortalita na CHOPN (kódy J40 – J44) stoupla v ČR od r. 1996 do r. 2009 o 116 % (10,3/100 000 obyvatel v r. 1994 na 22,2 v r. 2009).
The evaluation of COPD mortality between tiie years 2008 and 2009 was as follows: Absolute number in men 1,275/1,448 (+14 %), in women 821/886 (+8 %), N/100,000 in men 24.9/28.1 (+13 %), in women 15.4/16.6 (+8 %), N/100,000 (European standard) in men 23.0/25.5 (+11 %), in women 9.2/9.6 (+4 %). Code J44 accounted for 90% of COPD mortality codes (J40-J44). COPD mortality was ranked the 6th among the main causes of mortality in tiie Czech Republic in 2009, just after ischemic heart disease, cerebrovascular diseases, lung cancer, colorectal cancer and pneumonia. COPD (codes J40-J44) in the Czech Republic increased by 116 % between the years 1996 and 2009 (from 10.3/100,000 inhabitants in 1996 to 22.2 in 2009).
- MeSH
- Pulmonary Disease, Chronic Obstructive mortality MeSH
- Humans MeSH
- Mortality trends MeSH
- Sex Distribution MeSH
- Age Distribution MeSH
- Check Tag
- Humans MeSH
- Geographicals
- Czech Republic MeSH
Acta chirurgiae orthopaedicae et traumatologiae čechoslovaca, ISSN 0001-5415 Ročník 78, Supplementum A/2011
72 stran : ilustrace, tabulky ; 30 cm
- MeSH
- Survival Analysis MeSH
- Arthroplasty, Replacement, Hip MeSH
- Registries MeSH
- Reoperation MeSH
- Data Collection statistics & numerical data MeSH
- Publication type
- Chart MeSH
- Statistics MeSH
- Tables MeSH
- Geographicals
- Czech Republic MeSH
- Conspectus
- Ortopedie. Chirurgie. Oftalmologie
- NML Fields
- ortopedie
- traumatologie
- NML Publication type
- studie
