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MeSH: Complement C3b

14 hits in Medvik Filters

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Autoimunitná hemolytická anémia s chladovými aglutinínmi pri lymfoproliferatívnom ochorení

Lukáš, Jozef
Author Authority Klinika hematologie a transfúziológie LF UK, SZU a UN, Bratislava

Hematologie a hematoonkologie v kazuistikách. 2020 ; () : 27-30.

ISBN 978-80-7345-681-8
Medvik
Source

MeSH
Anemia, Hemolytic, Autoimmune * diagnosis drug therapy blood pathology MeSH
Coombs Test MeSH
Hematologic Tests MeSH
Hemoglobins analysis drug effects MeSH
Complement C3d analysis MeSH
Humans MeSH
Rituximab administration & dosage MeSH
Aged MeSH
Waldenstrom Macroglobulinemia diagnosis complications MeSH
Check Tag
Humans MeSH
Aged MeSH
Female MeSH
Publication type
Case Reports MeSH

Online article

Antibody-mediated rejection after liver transplantation-relevance of C1q and C3d-binding antibodies

HLA. 2018 ; 92 Suppl 2 (-) : 34-37. [pub] -

ISSN 2059-2310
Medvik
Source

The aim of our study was to evaluate the relevance of complement-binding donor-specific antibodies (DSA) for prediction of antibody-mediated rejection (AMR) after liver transplantation. Sera from 123 liver transplant recipients were retrospectively defined for HLA specificity and complement-fixing activity using the single antigen beads, C1q and C3d techniques. Liver-recipients' sera were tested before transplantation, 3, 6 months and 1 year after transplantation. Patients were followed up for graft survival and rejection incidence for 1 year after transplantation. All patients with pretransplant complement-binding DSA developed severe AMR after transplantation, while three recipients out of four, who produced de novo complement-fixing DSA, developed AMR. Definition of DSA with respect to complement-fixing activity may provide clinically relevant information about the risk of AMR after liver transplantation.

MeSH
Tissue Donors MeSH
Child MeSH
Adult MeSH
Transplantation, Homologous MeSH
Isoantibodies blood MeSH
Complement C1q metabolism MeSH
Complement C3d metabolism MeSH
Middle Aged MeSH
Humans MeSH
Adolescent MeSH
Follow-Up Studies MeSH
Graft Survival * MeSH
Prognosis MeSH
Graft Rejection blood diagnosis immunology pathology MeSH
Retrospective Studies MeSH
Aged MeSH
Histocompatibility Testing methods MeSH
Liver Transplantation * MeSH
Check Tag
Child MeSH
Adult MeSH
Middle Aged MeSH
Humans MeSH
Adolescent MeSH
Male MeSH
Aged MeSH
Female MeSH
Publication type
Journal Article MeSH
Research Support, Non-U.S. Gov't MeSH

Online article

Specific adsorption of some complement activation proteins to polysulfone dialysis membranes during hemodialysis

Kidney international. 2009 ; 76 (4) : 404-413.

Kidney Int
Medvik
Source

Dialyser bioincompatibility is an important factor contributing to complications of hemodialysis with well known systemic consequences. Here we studied the local processes that occur on dialysis membranes by eluting proteins adsorbed to the polysulfone dialyser membranes of 5 patients after 3 consecutive routine maintenance hemodialysis sessions. At the end of each procedure, a plasma sample was also collected. These eluates and their accompanying plasma samples were separated by 2-dimensional gel electrophoresis; all proteins that were present in all patients were analyzed by tandem mass spectrometry; and a ratio of the relative spot intensity of the eluate to plasma was calculated. Of 153 proteins detected, 84 were found in all patients, 57 of which were successfully identified by mass spectrometry as 38 components of 23 unique proteins. In 10 spots the relative eluate intensity differed significantly from that in the plasma, implying preferential adsorption. These proteins included ficolin-2, clusterin, complement C3c fragment, and apolipoprotein A1. Our finding of a selective binding of ficolin-2 to polysulfone membranes suggests a possible role of the lectin complement pathway in blood-dialyser interactions.