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8 záznamů v Medvik Filtry

Článek

Does one size fit all? The role of body mass index and waist circumference in systemic inflammation in midlife by race and gender

Stepanikova, Irena
Autor Stepanikova, Irena a Department of Sociology , University of Alabama at Birmingham , Birmingham , AL , USA. b Research Centre for Toxic Compounds in the Environment , Masaryk University , Brno , Czech Republic
Oates, Gabriela R
Autor Oates, Gabriela R c School of Medicine, Division of Preventive Medicine , University of Alabama at Birmingham , Birmingham , AL , USA
Bateman, Lori Brand
Autor Bateman, Lori Brand c School of Medicine, Division of Preventive Medicine , University of Alabama at Birmingham , Birmingham , AL , USA

Ethnicity & health. 2017 ; 22 (2) : 169-183. [pub] 20161024

Ethn Health
ISSN 1465-3419
Medvik
Zdroj

OBJECTIVE: This study investigates the associations of body mass index (BMI) and waist circumference (WC) with markers of systemic inflammation in midlife by race and gender. DESIGN: Data were obtained from the Survey of Midlife in the United States, a cross-sectional, observational study of Americans 35 years old or older (White men: N = 410; White women: N = 490; Black men: N = 58; Black women: N = 117). Inflammation was measured by concentrations of fibrinogen and C-reactive protein (CRP) in fasting plasma and concentrations of E-selectin and interleukin-6 (IL-6) in fasting serum. Anthropometric data were used to obtain BMI and WC. Socio-demographic and health-related factors were assessed with a survey. Multivariate models by race and gender were estimated to test the roles of BMI and WC for each inflammation marker. RESULTS: Compared to White men, Black women have higher BMI and higher levels of all four inflammation markers; White women have lower BMI, lower WC, and lower E-selectin and fibrinogen but higher CRP; and Black men have higher fibrinogen. After adjusting for socio-demographic and health-related covariates as well as perceived discrimination, WC is associated with all four markers of inflammation among White men and women; with three markers (fibrinogen, CRP, and IL-6) of inflammation among Black women; and with CRP (and marginally with fibrinogen and E-selectin) among Black men. BMI is associated with higher CRP and fibrinogen among Black men (marginally so for White men) but not for women of either race. CONCLUSIONS: WC shows more consistent associations with inflammation markers than BMI, although the relationships vary by inflammation marker and population group. Our findings suggest that WC is a risk factor for systemic inflammation among White and Black men and women, and BMI is an additional risk factor for Black men.

MeSH
běloši statistika a číselné údaje MeSH
biologické markery MeSH
C-reaktivní protein biosyntéza MeSH
černoši nebo Afroameričané statistika a číselné údaje MeSH
dospělí MeSH
E-selektin biosyntéza MeSH
fibrinogen biosyntéza MeSH
index tělesné hmotnosti * MeSH
interleukin-6 biosyntéza MeSH
lidé středního věku MeSH
lidé MeSH
mediátory zánětu MeSH
obvod pasu * MeSH
průřezové studie MeSH
rizikové faktory MeSH
senioři nad 80 let MeSH
senioři MeSH
sexuální faktory MeSH
socioekonomické faktory MeSH
tělesné váhy a míry MeSH
zánět etnologie patofyziologie MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři nad 80 let MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
pozorovací studie MeSH
práce podpořená grantem MeSH
Research Support, N.I.H., Extramural MeSH
Geografické názvy
Spojené státy americké MeSH

Článek

Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls

PLoS One. 2017 ; 12 (6) : e0179063. [pub] 20170606

ISSN 1932-6203
Medvik
Zdroj

Chronic low-grade inflammation plays an important role in the pathogenesis of insulin resistance. In the current study, we tested the effects of salsalate, a non-steroidal anti-inflammatory drug, in an animal model of inflammation and metabolic syndrome using spontaneously hypertensive rats (SHR) that transgenically express human C-reactive protein (SHR-CRP rats). We treated 15-month-old male transgenic SHR-CRP rats and nontransgenic SHR with salsalate (200 mg/kg/day) mixed as part of a standard diet for 4 weeks. A corresponding untreated control group of male transgenic SHR-CRP and SHR rats were fed a standard diet without salsalate. In the SHR-CRP transgenic strain, salsalate treatment decreased circulating concentrations of the inflammatory markers TNF-α and MCP-1, reduced oxidative stress in the liver and kidney, increased sensitivity of skeletal muscles to insulin action and improved tolerance to glucose. In SHR controls with no CRP-induced inflammation, salsalate treatment reduced body weight, decreased concentrations of serum free fatty acids and total and HDL cholesterol and increased palmitate oxidation and incorporation in brown adipose tissue. Salsalate regulated inflammation by affecting the expression of genes from MAPK signalling and NOD-like receptor signalling pathways and lipid metabolism by affecting hepatic expression of genes that favour lipid oxidation from PPAR-α signalling pathways. These findings suggest that salsalate has metabolic effects beyond suppressing inflammation.

MeSH
C-reaktivní protein biosyntéza genetika MeSH
geneticky modifikovaná zvířata genetika MeSH
hnědá tuková tkáň metabolismus MeSH
hypertenze farmakoterapie genetika patologie MeSH
inzulinová rezistence genetika MeSH
játra metabolismus MeSH
krysa rodu rattus MeSH
kyseliny mastné neesterifikované metabolismus MeSH
lidé MeSH
metabolický syndrom farmakoterapie genetika patologie MeSH
metabolismus lipidů účinky léků MeSH
NLR proteiny biosyntéza MeSH
oxidační stres účinky léků MeSH
PPAR alfa biosyntéza MeSH
salicylany aplikace a dávkování MeSH
TNF-alfa biosyntéza MeSH
zánět farmakoterapie genetika patologie MeSH
zvířata MeSH
Check Tag
krysa rodu rattus MeSH
lidé MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH

Článek

Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein

PLoS One. 2016 ; 11 (3) : e0150924. [pub] 20160310

ISSN 1932-6203
Medvik
Zdroj

Inflammation and oxidative and dicarbonyl stress play important roles in the pathogenesis of type 2 diabetes. Metformin is the first-line drug of choice for the treatment of type 2 diabetes because it effectively suppresses gluconeogenesis in the liver. However, its "pleiotropic" effects remain controversial. In the current study, we tested the effects of metformin on inflammation, oxidative and dicarbonyl stress in an animal model of inflammation and metabolic syndrome, using spontaneously hypertensive rats that transgenically express human C-reactive protein (SHR-CRP). We treated 8-month-old male transgenic SHR-CRP rats with metformin (5 mg/kg/day) mixed as part of a standard diet for 4 weeks. A corresponding untreated control group of male transgenic SHR-CRP rats were fed a standard diet without metformin. In a similar fashion, we studied a group of nontransgenic SHR treated with metformin and an untreated group of nontransgenic SHR controls. In each group, we studied 6 animals. Parameters of glucose and lipid metabolism and oxidative and dicarbonyl stress were measured using standard methods. Gene expression profiles were determined using Affymetrix GeneChip Arrays. Statistical significance was evaluated by two-way ANOVA. In the SHR-CRP transgenic strain, we found that metformin treatment decreased circulating levels of inflammatory response marker IL-6, TNFα and MCP-1 while levels of human CRP remained unchanged. Metformin significantly reduced oxidative stress (levels of conjugated dienes and TBARS) and dicarbonyl stress (levels of methylglyoxal) in left ventricles, but not in kidneys. No significant effects of metformin on oxidative and dicarbonyl stress were observed in SHR controls. In addition, metformin treatment reduced adipose tissue lipolysis associated with human CRP. Possible molecular mechanisms of metformin action-studied by gene expression profiling in the liver-revealed deregulated genes from inflammatory and insulin signaling, AMP-activated protein kinase (AMPK) signaling and gluconeogenesis pathways. It can be concluded that in the presence of high levels of human CRP, metformin protects against inflammation and oxidative and dicarbonyl stress in the heart, but not in the kidney. Accordingly, these cardioprotective effects of metformin might be especially effective in diabetic patients with high levels of CRP.