Menopauza je u mnoha žen spojena s řadou příznaků estrogendeficitního syndromu, které zvyšují morbiditu a zhoršují kvalitu života. Tyto příznaky zahrnují vazomotorické a urogenitální symptomy, ale také závažné nemoci, jako jsou osteoporóza a kardiovaskulární onemocnění. Hormonální terapie, doporučovaná v období menopauzálního přechodu, je nejúčinnější léčbou vazomotorických i urogenitálních potíží. Studie WHI a mnohé další studie ukázaly, že hormonální terapie zvyšuje minerální denzitu kosti u postmenopauzálních žen, významně snižuje riziko osteoporotických zlomenin a v časné postmenopauze snižuje riziko ischemické nemoci srdeční. Estrogeny by měly být lékem první volby v prevenci a léčbě osteoporózy u žen do 60 let.
For many women, menopause is associated with a range of symptoms of estrogen-deficiency syndrome that contribute to increased morbidity and reduced quality of life. These include vasomotor symptoms and urogenital symptoms as well as postmenopausal osteoporosis and cardiovascular disease. Hormone therapy (HT) commenced during the menopausal transition is the most effective treatment available for vasomotor and urogenital symptoms. The WHI study and many other studies showed that HT also increased bone mineral density in postmenopausal women, significantly reduced their risk of osteoporotic fractures and reduced risk of coronary heart disease in early postmenopause. Estrogens should be the first-choice therapy for osteoporosis prevention and treatment in women under 60.
- Keywords
- hormonální léčba, estrogenní deficit,
- MeSH
- Estrogens deficiency therapeutic use MeSH
- Hormone Replacement Therapy contraindications statistics & numerical data trends MeSH
- Carcinoma epidemiology MeSH
- Cardiovascular Diseases prevention & control MeSH
- Humans MeSH
- Menopause ethnology drug effects MeSH
- Metabolic Syndrome diagnosis therapy MeSH
- Genital Neoplasms, Female diagnosis epidemiology MeSH
- Obesity prevention & control therapy MeSH
- Osteoporosis MeSH
- Osteoporosis, Postmenopausal drug therapy prevention & control MeSH
- Menopause, Premature drug effects MeSH
- Risk MeSH
- Women's Health MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- MeSH
- Hormone Replacement Therapy contraindications statistics & numerical data utilization MeSH
- Cardiovascular Diseases MeSH
- Clinical Trials as Topic MeSH
- Contraceptives, Oral, Combined contraindications adverse effects therapeutic use MeSH
- Humans MeSH
- Risk MeSH
- Age Factors MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- MeSH
- Estrogen Replacement Therapy statistics & numerical data MeSH
- Hormone Replacement Therapy statistics & numerical data MeSH
- Humans MeSH
- Menopause drug effects MeSH
- Joint Diseases prevention & control MeSH
- Osteoarthritis MeSH
- Arthritis, Rheumatoid MeSH
- Lupus Erythematosus, Systemic MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- MeSH
- Estrogen Replacement Therapy methods statistics & numerical data utilization MeSH
- Hormone Replacement Therapy methods statistics & numerical data utilization MeSH
- Humans MeSH
- Melanoma epidemiology etiology MeSH
- Skin Aging ethnology pathology MeSH
- Aging physiology MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- MeSH
- Estrogen Replacement Therapy statistics & numerical data MeSH
- Hormone Replacement Therapy statistics & numerical data MeSH
- Myocardial Ischemia epidemiology pathology prevention & control MeSH
- Clinical Trials as Topic statistics & numerical data MeSH
- Humans MeSH
- Postmenopause drug effects MeSH
- Primary Prevention MeSH
- Risk Factors MeSH
- Secondary Prevention MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- MeSH
- Estrogens therapeutic use MeSH
- Hormone Replacement Therapy methods statistics & numerical data trends MeSH
- Clinical Trials as Topic statistics & numerical data MeSH
- Humans MeSH
- Osteoporosis, Postmenopausal drug therapy prevention & control MeSH
- Risk MeSH
- Secondary Prevention MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- MeSH
- Adult MeSH
- Endometriosis drug therapy surgery therapy MeSH
- Estradiol pharmacokinetics pharmacology therapeutic use MeSH
- Estrogen Replacement Therapy MeSH
- Research Support as Topic MeSH
- Risk Assessment MeSH
- Hormone Replacement Therapy methods statistics & numerical data trends MeSH
- Climacteric drug effects MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Norpregnenes administration & dosage therapeutic use MeSH
- Treatment Refusal statistics & numerical data MeSH
- Recurrence MeSH
- Patient Satisfaction statistics & numerical data MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Randomized Controlled Trial MeSH
