• MeSH
• Alanine Transaminase blood   MeSH
• Alkaline Phosphatase physiology   blood   MeSH
• Aspartate Aminotransferases blood   MeSH
• Bilirubin physiology   blood   MeSH
• Diagnosis, Differential MeSH
• gamma-Glutamyltransferase physiology   blood   MeSH
• Hyperbilirubinemia classification   MeSH
• Liver Function Tests * classification   MeSH
• Humans MeSH
• Liver Diseases diagnosis   prevention & control   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• MeSH
• Bilirubin physiology   MeSH
• Diagnosis, Differential MeSH
• Gilbert Disease diagnosis   physiopathology   MeSH
• Hyperbilirubinemia * etiology   classification   MeSH
• Humans MeSH
• Jaundice, Chronic Idiopathic diagnosis   MeSH
• Jaundice * classification   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

Bilirubin is a tetrapyrrolic compound originating from heme catabolism. Although originally considered only a potentially dangerous waste product, it has become increasingly evident that this molecule represents an important modulator of various biological functions in the human body. Bilirubin appears to have versatile functions, from cell signaling (behaving almost like a "real" hormonal substance), modulation of metabolism, to immune regulation, affecting biological activities with apparent clinical and even therapeutic consequences. These activities may be the reason for the lower incidence of diseases of civilisation (cardiovascular diseases, arterial hypertension, diabetes, obesity, metabolic syndrome, certain cancers, autoimmune, and neurodegenerative diseases) observed in individuals with a chronic mild unconjugated hyperbilirubinemia, a typical sign of Gilbert's syndrome. While higher serum concentrations of unconjugated bilirubin may serve as an important protective factor against these diseases, low levels of bilirubin are associated with the opposite effect.

• MeSH
• Color MeSH
• Bilirubin analysis   classification   MeSH
• Heme metabolism   MeSH
• Hyperbilirubinemia classification   physiopathology   MeSH
• Humans MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

• MeSH
• Alkaline Phosphatase blood   MeSH
• Cholestasis diagnosis   etiology   MeSH
• Diagnosis, Differential MeSH
• Hyperbilirubinemia etiology   classification   MeSH
• Liver Function Tests * classification   MeSH
• Liver pathology   MeSH
• Humans MeSH
• Liver Diseases diagnosis   etiology   MeSH
• Transaminases blood   MeSH
• Check Tag
• Humans MeSH

• MeSH
• Cholestasis * etiology   genetics   classification   MeSH
• Crigler-Najjar Syndrome etiology   genetics   classification   MeSH
• Hyperbilirubinemia, Hereditary diagnosis   etiology   genetics   MeSH
• Genetic Diseases, Inborn * diagnosis   etiology   genetics   MeSH
• Gilbert Disease diagnosis   etiology   genetics   MeSH
• Hyperbilirubinemia * etiology   genetics   classification   MeSH
• Cholestasis, Intrahepatic etiology   genetics   classification   MeSH
• Pregnancy Complications diagnosis   etiology   genetics   MeSH
• Humans MeSH
• Jaundice, Chronic Idiopathic diagnosis   etiology   genetics   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• MeSH
• Blood Chemical Analysis methods   MeSH
• Hematology methods   MeSH
• Hemolysis MeSH
• Hyperbilirubinemia classification   MeSH
• Hyperkalemia classification   MeSH
• Immunochemistry methods   MeSH
• Immunophenotyping MeSH
• Clinical Laboratory Techniques * methods   standards   instrumentation   MeSH
• Hematologic Diseases * diagnosis   MeSH
• Cryoglobulins classification   MeSH
• Humans MeSH
• Paraproteinemias MeSH
• Prealbumin analysis   MeSH
• Flow Cytometry methods   utilization   MeSH
• Check Tag
• Humans MeSH

• MeSH
• Hyperbilirubinemia * diagnosis   classification   therapy   MeSH
• Humans MeSH
• Neonatology MeSH
• Infant, Newborn MeSH
• Check Tag
• Humans MeSH
• Infant, Newborn MeSH
• Publication type
• Practice Guideline MeSH

Cílem předkládané publikace je shrnout současné poznatky v této rychle se rozvíjející oblasti a nastínit další možné klinické konsekvence. Jedná se zejména o vztah bilirubinu k onemocněním podmíněných oxidačním stresem, jako jsou kardiovaskulární nemoci, nádorová či revmatologická onemocnění.Publikace řeší oproti ostatním publikacím na trhu, kterých je minimálně, nový přístup k tematice - neopomíjí moderní poznatky, a ustupuje tedy od tradičního pojetí, zabývá se i interdisciplinárním významem poruch metabolismu bilirubinu, epidemiologií chorob podmíněných oxidačním stresem ve vztahu k hladinám bilirubinu apod.Kniha je určena zejména gastroenterologům, hepatologům, internistům, ale i praktickým lékařům, studentům medicíny i široké odborné veřejnosti.

• Keywords
• Gastroenterologie, hepatologie, Interna, Metabolizmus, imunita, Teoretické obory,
• MeSH
• Bilirubin analysis   blood   metabolism   MeSH
• Hemoglobins chemistry   MeSH
• Hyperbilirubinemia classification   blood   metabolism   MeSH
• Clinical Laboratory Techniques MeSH
• Jaundice classification   blood   metabolism   MeSH

• NML Fields
• vnitřní lékařství
• biochemie
• hematologie a transfuzní lékařství
• vnitřní lékařství

• MeSH
• Bilirubin analysis   blood   metabolism   MeSH
• Hemoglobins chemistry   MeSH
• Hyperbilirubinemia classification   blood   metabolism   MeSH
• Clinical Laboratory Techniques MeSH
• Jaundice classification   blood   metabolism   MeSH
• Publication type
• Monograph MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• vnitřní lékařství
• biochemie
• hematologie a transfuzní lékařství
• vnitřní lékařství

• MeSH
• Bilirubin analysis   MeSH
• Crigler-Najjar Syndrome diagnosis   MeSH
• Diagnosis, Differential MeSH
• Hyperbilirubinemia, Hereditary diagnosis   classification   MeSH
• Gilbert Disease diagnosis   MeSH
• Hyperbilirubinemia diagnosis   classification   MeSH
• Cholestasis, Intrahepatic diagnosis   etiology   pathology   MeSH
• Humans MeSH
• Liver Diseases * etiology   classification   MeSH
• Jaundice diagnosis   etiology   MeSH
• Bile Acids and Salts analysis   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Lecture MeSH