BACKGROUND: Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes. METHODS: TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enrolled from 32 hospitals participating in the International Takotsubo Registry. Clinical characteristics and in-hospital outcomes were compared between Japanese and European patients. RESULTS: A total of 503 Japanese and 1670 European patients were included. Japanese patients were older (72.6 ± 11.4 years vs. 68.0 ± 12.0 years; p < 0.001) and more likely to be male (18.5 vs. 8.4%; p < 0.001) than European TTS patients. Physical triggering factors were more common (45.5 vs. 32.0%; p < 0.001), and emotional triggers less common (17.5 vs. 31.5%; p < 0.001), in Japanese patients than in European patients. Japanese patients were more likely to experience cardiogenic shock during the acute phase (15.5 vs. 9.0%; p < 0.001) and had a higher in-hospital mortality (8.2 vs. 3.2%; p < 0.001). However, ethnicity itself did not appear to have an impact on in-hospital mortality. Machine learning approach revealed that the presence of physical stressors was the most important prognostic factor in both Japanese and European TTS patients. CONCLUSION: Differences in clinical characteristics and in-hospital outcomes between Japanese and European TTS patients exist. Ethnicity does not impact the outcome in TTS patients. The worse in-hospital outcome in Japanese patients, is mainly driven by the higher prevalence of physical triggers. TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique Identifier: NCT01947621.

• MeSH
• Asijci etnologie   statistika a číselné údaje   MeSH
• běloši etnologie   statistika a číselné údaje   MeSH
• disparity zdravotního stavu MeSH
• kardiogenní šok etnologie   mortalita   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mortalita v nemocnicích etnologie   MeSH
• prevalence MeSH
• registrace MeSH
• senioři MeSH
• takotsubo kardiomyopatie etnologie   mortalita   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Evropa MeSH
• Japonsko MeSH

β-Thalassemia (β-thal) is considered rare in Central Europe. As in other malaria-free regions, the presence of β-thal in Central Europe reflects historical and recent immigration, and demographic changes that have influenced the genetic variability of the current populations living in this area. This study assesses the frequency and spectrum of mutations on the β-globin gene in Czech and Slovak subjects with clinical symptoms of thalassemia. The results of the initial part of this research were published more than two decades ago; the aim of this study was to update these original reports. During the period from 2002 to 2015, 400 cases from Czech and Slovak hematological centers were analyzed. Twenty-nine β-thal mutations, identified in 356 heterozygotes from 218 unrelated families, involve five unique mutations including a recently described insertion of a transposable L1 element into the β-globin gene. One mutation described here is reported for the first time. Most of the mutations were of Mediterranean origin and accounted for 82.0% of cases. All but one case studied were heterozygous carriers, manifesting β-thal minor, with rare exceptions represented by the rare (β(0)) codons 46/47 (+G) (HBB: c.142_142dupG) mutation associated with an α-globin gene quadruplication and by dominantly inherited β-thal with a more severe phenotype. One double heterozygous β-thal patient was a recent immigrant from Moldavia. The list of δβ-thal alleles (26 carriers, 16 families) contains Hb Lepore and two types of δβ(0)-thal deletions. In the past, genetic drift and migration as well as recent immigrations were responsible for the introduction of Mediterranean alleles, while several mutations described in single families were of local origin.

• MeSH
• Asijci etnologie   genetika   MeSH
• běloši etnologie   genetika   MeSH
• beta-globiny genetika   MeSH
• beta-talasemie epidemiologie   genetika   MeSH
• emigrace a imigrace MeSH
• frekvence genu MeSH
• genetický drift MeSH
• heterozygot MeSH
• lidé MeSH
• molekulární epidemiologie * MeSH
• mutace * MeSH
• rodokmen MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika epidemiologie   MeSH
• Slovenská republika epidemiologie   MeSH

• MeSH
• autoimunitní nemoci diagnóza   farmakoterapie   terapie   MeSH
• běloši etnologie   genetika   MeSH
• diferenciální diagnóza * MeSH
• farmakoterapie * metody   využití   MeSH
• klinický obraz nemoci MeSH
• kouření škodlivé účinky   MeSH
• lékařská geografie MeSH
• lidé MeSH
• magnetická rezonanční tomografie metody   využití   MeSH
• mozkomíšní mok MeSH
• nedostatek vitaminu D MeSH
• neurodegenerativní nemoci diagnóza   farmakoterapie   terapie   MeSH
• obezita MeSH
• psychický stres MeSH
• rizikové faktory MeSH
• roztroušená skleróza * diagnóza   epidemiologie   etiologie   MeSH
• sluneční záření MeSH
• statistika jako téma MeSH
• virové nemoci epidemiologie   imunologie   komplikace   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• rozhovory MeSH
• Geografické názvy
• Česká republika MeSH

In the majority of countries, surnames represent a ubiquitous cultural attribute inherited from an individual's ancestors and predominantly only altered through marriage. This paper utilises an innovative method, taken from economics, to offer unprecedented insights into the "surname space" of the Czech Republic. We construct this space as a network based on the pairwise probabilities of co-occurrence of surnames and find that the network representation has clear parallels with various ethno-cultural boundaries in the country. Our inductive approach therefore formalizes a simple assumption that the more frequently the bearers of two surnames concentrate in the same locations the higher the probability that these two surnames can be related (considering ethno-cultural relatedness, common co-ancestry or genetic relatedness, or some other type of relatedness). Using the Czech Republic as a case study this paper offers a fresh perspective on surnames as a quantitative data source and provides a methodology that can be easily incorporated within wider cultural, ethnic, geographic and population genetics studies already utilizing surnames.

• MeSH
• běloši etnologie   MeSH
• jména * MeSH
• kultura MeSH
• lidé MeSH
• populační genetika MeSH
• zeměpis MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Česká republika MeSH

• MeSH
• ateroskleróza epidemiologie   etiologie   MeSH
• běloši etnologie   MeSH
• černoši etnologie   MeSH
• cévní mozková příhoda epidemiologie   etnologie   MeSH
• fibrilace síní etiologie   komplikace   MeSH
• hypertenze etnologie   komplikace   MeSH
• kohortové studie MeSH
• komplikace diabetu etnologie   komplikace   MeSH
• kouření etnologie   škodlivé účinky   MeSH
• lidé středního věku MeSH
• lidé MeSH
• obezita etnologie   komplikace   MeSH
• pohlavní dimorfismus MeSH
• prevalence MeSH
• prospektivní studie MeSH
• rizikové faktory MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• práce podpořená grantem MeSH

• MeSH
• běloši etnologie   genetika   MeSH
• fenotyp MeSH
• financování organizované MeSH
• genetický výzkum MeSH
• genotyp MeSH
• infarkt myokardu * genetika   krev   metabolismus   MeSH
• inhibiční faktory migrace makrofágů * genetika   krev   MeSH
• lidé MeSH
• nemoci koronárních tepen genetika   krev   MeSH
• polymorfismus genetický * genetika   MeSH
• statistika jako téma MeSH
• Check Tag
• lidé MeSH
• Geografické názvy
• Česká republika MeSH
• Rusko MeSH

Aim: Chemerin is a novel adipokine that has been suggested to play an important role in the pathogenesis of themetabolic syndrome. The aim of our study was to evaluate serum chemerin as a marker of the metabolic syndromeand to assess its predictive accuracy in a Caucasian population. Methods: The study was designed as a cross-sectional study. Anthropometric measurements and serum analyseswere done for Body Mass Index, waist circumference, chemerin, insulin, triacylglycerides, total cholesterol, HDLcholesterol,LDL-cholesterol, uric acid, and glucose in 55 non-obese healthy subjects and 181 subjects at risk for themetabolic syndrome. ROC curves were determined and the Chi-squared test was used to analyse the data. Results: Compared with healthy controls, subjects with suspected metabolic syndrome had signifi cantly higherchemerin serum levels (medians: 266.0 vs.192.5 µg/l; P < 0.01). After further chemerin adjustment, the diff erencebetween the subgroups persisted. Chemerin serum levels correlated with age (r = 0.23), serum glucose (r = 0.23),HDL-cholesterol (r = –0.19), triacylglycerides (r = 0.22), systolic and diastolic blood pressure (r = 0.40; r = 0.24) andthe number of metabolic syndrome risk factors (r = 0.47). At a serum chemerin cut-off level of 240 µg/l, the presenceof the metabolic syndrome was diagnosed with 75 % sensitivity and 67 % specifi city.Conclusion: In conclusion, serum chemerin levels are associated with the characteristics of the metabolic syndromeand could be an independent marker of this disorder in a Caucasian population.

• MeSH
• adipokiny izolace a purifikace   MeSH
• antropometrie metody   MeSH
• běloši etnologie   genetika   MeSH
• biologické markery krev   MeSH
• chemokiny izolace a purifikace   MeSH
• cholesterol izolace a purifikace   klasifikace   krev   MeSH
• ELISA metody   využití   MeSH
• glukosa izolace a purifikace   MeSH
• index tělesné hmotnosti MeSH
• inzulin izolace a purifikace   krev   MeSH
• kyselina močová izolace a purifikace   krev   MeSH
• lidé MeSH
• metabolický syndrom diagnóza   epidemiologie   genetika   MeSH
• průřezové studie MeSH
• statistika jako téma MeSH
• triglyceridy izolace a purifikace   krev   MeSH
• Check Tag
• lidé MeSH