Cardiovascular disease (CVD) is a leading cause of death worldwide. A key area of interest in CVD prevention is novel digital health technologies, primarily mobile health (mHealth) applications and wearable devices, that are rapidly transforming the methods of preventing and managing CVD. Studies have shown the success of smartphone applications, such as the RITMIA app (Heart SentinelTM, Parma, Italy), in successfully detecting atrial fibrillation (Afib) compared to a classic 12-lead electrocardiogram (ECG). mHealth devices should integrate these factors, based on artificial intelligence (AI) and driven by chatbots, to encourage patients to use technology through interactive, real-world, motivational, and timely feedback. Data from mHealth clinical research indicate improved medication adherence, weight control, and self-care among patients. This review highlights mHealth and wearable devices in CVD prevention, providing foresight into cardiovascular health conditions through continuous monitoring, early detection, and improved patient engagement. Additionally, it examines challenges, including ethical, regulatory, and accessibility issues, that need to be addressed before their widespread adoption. In the future, the priority must be integration with healthcare systems and equitable access. A thorough search was conducted using reputable databases such as Scopus, PubMed, and Google Scholar. Articles from 2015 to 2025, along with an article from 2002 published in reputable peer-reviewed journals, were analyzed and contextually used. We also refined our search terms and used high-quality English articles to achieve this.
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Cadaveric spasm, also known as instantaneous rigor, is a rare and poorly understood phenomenon characterized by immediate muscle rigidity at the moment of death or cardiac arrest. This can result in severe trismus, making conventional airway management impossible. We present a case of a morbidly obese patient who suffered a sudden cardiac arrest with instantaneous rigor, necessitating an urgent surgical cricothyrotomy. This report underscores the need for early recognition of this condition, rapid decision-making regarding airway management, and the importance of specialized training for emergency physicians, particularly in anatomically challenging scenarios.
- Publikační typ
- časopisecké články MeSH
Pedagogika
Vydání 1. 140 stran ; 24 cm
Publikace se zaměřuje na péči o děti s chronickou nemocí ve školce. Určeno odborné veřejnosti.; Kniha se zaměřuje na problematiku chronických onemocnění u dětí předškolního věku a na roli, kterou v této oblasti hrají učitelé mateřských škol. Výzkumy upozorňují na význam jasných zásad a pravidelného školení zaměstnanců mateřských škol v oblasti prevence a managementu nemocí, přesto se učitelé potýkají s řadou obtíží, které souvisejí zejména s péčí o chronicky nemocné děti a se zvládáním jejich specifických potřeb, jako jsou poruchy výživy nebo prevence přenosných infekcí. Studie zdůrazňují potřebu komplexního přístupu, který zahrnuje efektivní zdravotní péči, konkrétní směrnice a pravidelné vzdělávání pracovníků mateřských škol. To je zásadní pro vytvoření bezpečného a podpůrného prostředí pro děti s chronickými onemocněními. Autoři podrobně popisují výzvy, jimž děti s chronickými onemocněními čelí, a zdůrazňují význam porozumění těmto problémům. Publikace si klade za cíl vyplnit mezery v odborných znalostech učitelů v oblasti chronických onemocnění a nabídnout jim metodologickou podporu pro práci s těmito dětmi.
- MeSH
- chronická nemoc MeSH
- péče o dítě * MeSH
- pediatrické ošetřovatelství MeSH
- předškolní dítě MeSH
- školky MeSH
- vyučování MeSH
- Check Tag
- předškolní dítě MeSH
- Konspekt
- Pediatrie
- NLK Obory
- pediatrie
- pedagogika
- NLK Publikační typ
- kolektivní monografie
BACKGROUND: Liver glycogen storage disorders (GSDs) are rare inherited disorders of carbohydrate metabolism that are clinically characterized by hepatomegaly and fasting intolerance. This group of disorders comprises GSD Ia and Ib as well as the so-called ketotic GSDs including GSD III, VI, IX, XI and 0a. Although clinical practice guidelines exist for most GSD subtypes, diagnostics, treatment and monitoring differ significantly among metabolic centres. The aim of this study was to gain insight into current clinical practice for liver GSDs. METHODS: An international web-based survey was performed among health care professionals involved in the care of individuals with liver GSDs. RESULTS: Sixty-seven respondents from 28 different countries caring for approximately 2650 liver GSD patients completed the survey. While the diagnostic approach was generally consistent, significant differences among metabolic centres are still observed with respect to monitoring parameters and treatment approaches. Reasons for these differences are local availability of management tools and treatment options, the rarity of the different GSD subtypes, the experiences of health care professionals, and the existence of extreme phenotypes. CONCLUSION: The development of a standard set of outcomes for patients with liver GSDs is warranted as a reference for both daily care and the evaluation of safety and efficacy of future therapies. For various parameters that serve as valuable outcome measures, tools and target values should be better defined.
- MeSH
- glykogenóza * terapie diagnóza MeSH
- játra metabolismus patologie MeSH
- lidé MeSH
- management nemoci MeSH
- nemoci jater * terapie diagnóza MeSH
- průzkumy a dotazníky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Patient safety in undergraduate nursing studies is an indispensable component of the curriculum. The process of experiential learning from practice is of high value not only in terms of personal development but also enables students to identify and address critical areas of patient safety that require improvement. AIM: To explore Czech undergraduate nursing students' perceptions of patient safety culture during clinical practice through a mixed-method sequential study. METHODS: Data were collected between 2021 and 2024 using a mixed-method approach. The quantitative phase utilised the hospital survey on patient safety culture for nursing students. Four hundred and eighty-two undergraduate nursing students from 16 faculties across the Czech Republic participated. The subsequent qualitative phase employed semi-structured interviews with 12 undergraduate nursing students from one faculty in the Czech Republic. Descriptive and inferential statistical methods were used to analyse quantitative results, complemented by a reflective thematic analysis of qualitative data. RESULTS: The most negatively rated survey dimensions were 'Frequency of events reported' (37.0%) and 'Nonpunitive responses to errors' (42.4%). Predictors for reporting adverse events in clinical practice were 'Indicators of good practice' (p ≤ 0.05). Based on the quantitative phase, the interpretive journey of nursing students' experiences from Exposure to adverse events, through Feeling disconnected and Cognitive dissonance, to the necessity of Speaking up for patient safety culture was captured in the qualitative phase. CONCLUSIONS: Nursing students struggle to engage in a patient safety culture, particularly in reporting adverse events during clinical practice. Strengthening education on reporting and standards is essential for students, along with professional development for clinical staff to align practices and cultures.
- MeSH
- bezpečnost pacientů * normy MeSH
- dospělí MeSH
- kvalitativní výzkum MeSH
- lidé MeSH
- mladý dospělý MeSH
- postoj zdravotnického personálu * MeSH
- průzkumy a dotazníky MeSH
- studenti ošetřovatelství * psychologie MeSH
- studium ošetřovatelství bakalářské MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
T-cell engagers represent a transformative approach to cancer immunotherapy leveraging bispecific and multispecific antibody constructs to redirect T-cell cytotoxicity toward malignant cells. These molecules bridge T cells and tumor cells by simultaneously binding CD3 on T cells and tumor-associated antigens on cancer cells, thereby enabling precise immune targeting even in immunologically "cold" tumors. Recent advancements include conditional T-cell engagers activated by tumor microenvironment proteases to minimize off-tumor toxicity as well as T-cell receptor-based engagers targeting intracellular antigens via MHC presentation. Clinical successes, such as Kimmtrak in metastatic uveal melanoma, underscore good potential of these modalities, while challenges persist in the management of cytokine release syndrome, neurotoxicity, and tumor resistance. Emerging multispecific engagers are aimed at enhancing efficacy via incorporation of costimulatory signals, thus offering a promising trajectory for next-generation immunotherapies. T-cell engagers are also gaining attention in the treatment of autoimmune disorders, where they can be designed to selectively modulate pathogenic immune responses. By targeting autoreactive T or B cells, T-cell engagers hold promise for restoring immune tolerance in such conditions as HLA-B*27-associated autoimmunity subtypes, multiple sclerosis, rheumatoid arthritis, and type 1 diabetes mellitus. Engineering strategies that incorporate inhibitory receptors or tissue-specific antigens may further refine T-cell engagers' therapeutic potential in autoimmunity, by minimizing systemic immunosuppression while preserving immune homeostasis.
- MeSH
- imunoterapie * metody MeSH
- lidé MeSH
- nádorové mikroprostředí imunologie MeSH
- nádory * imunologie terapie MeSH
- protilátky bispecifické terapeutické užití imunologie MeSH
- receptory antigenů T-buněk imunologie metabolismus MeSH
- T-lymfocyty * imunologie metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
INTRODUCTION: Studies indicate that chronic treatment with mucoactive drugs may reduce COPD exacerbation rates. This real-world, multicenter, prospective, observational study aimed to determine the effect of long-term mucoactive treatment on exacerbations in patients with COPD in the Czech Republic. METHODS: 452 adult patients on the Czech Multicenter Research Database of COPD with post-bronchodilator FEV1 ≤ 60% of predicted value received standard of care and were followed up for 5 years. For the first 24 months, 81 patients received regular thiol-based mucoactive drugs (77 erdosteine, 4 N-acetylcysteine) at the discretion of the treating physician and 371 patients had no mucoactive treatment (control group). Erdosteine was fully reimbursed, and NAC was partially reimbursed for COPD patients. The annual number/rate of COPD exacerbations over 5 years was monitored. RESULTS: Patients receiving mucoactive treatment for 24 months had a significantly larger reduction from baseline in all exacerbations compared to the control group (- 0.61 vs - 0.18, p = 0.026; - 0.54 vs - 0.09, p = 0.007; - 0.55 vs 0.04, p = 0.005; - 0.67 vs 0.13, p = 0.002; - 0.53 vs 0.10, p = 0.019 in the first to fifth year, respectively). The reduction in moderate exacerbations was also significantly larger in those receiving mucoactive treatment versus no mucoactive treatment. The exacerbation rate was reduced to a greater extent in the subgroups with cough or with stage 3‒4 COPD who received mucoactive treatment but was independent of the use of inhaled corticosteroids (ICS). CONCLUSION: Mucoactive treatment for two years reduced the number of COPD exacerbations (all, moderate) over five years of follow-up. The reduction in exacerbations was more pronounced in patients with cough or with stage 3‒4 COPD but was independent of the use of ICS.
- MeSH
- acetylcystein * terapeutické užití MeSH
- časové faktory MeSH
- chronická obstrukční plicní nemoc * farmakoterapie patofyziologie diagnóza MeSH
- expektorancia * terapeutické užití MeSH
- lidé středního věku MeSH
- lidé MeSH
- následné studie MeSH
- progrese nemoci MeSH
- prospektivní studie MeSH
- senioři MeSH
- usilovný výdechový objem MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- pozorovací studie MeSH
- Geografické názvy
- Česká republika MeSH
JBI has long held the view that an inclusive approach to the conceptualization of what counts as evidence is important to the evidence-based movement. JBI's approach for appraising textual evidence had encompassed all forms of text (narrative, opinion, and policy), with one general tool used to guide critical appraisal. The proliferation of textual evidence and increase in textual evidence reviews demonstrate the need to reconceptualize JBI's methodological approach to critically appraising textual evidence. The objective of this paper is to outline the updated methodological approach to systematic reviews of textual evidence, especially in relation to the development of 3 separate critical appraisal tools for narrative, expert opinion, and policy text. Using an adapted Delphi approach, the JBI Textual Evidence Methodology Group convened over several rounds of meetings and discussions with international experts to reach consensus on the reconceptualization of critical appraisal tools for textual evidence sources. Strategies to effectively interrogate the legitimacy and authenticity of sources were found to be dependent upon the type of textual evidence under review. Therefore, 3 separate critical appraisal tools for narrative, expert opinion, and policy text were developed. This paper provides an overview of the development of 3 separate critical appraisal tools, highlighting the complex nature of textual evidence data sources.
