Údolní nádrž Seč slouží jako retenční prostor při povodních, dále jako zdroj pitné vody a v posledních desetiletích i jako významná rekreační oblast. Z důvodu eutrofizace i zde opakovaně docházelo k výskytu sinicového vodního květu. V červenci roku 2024 došlo ke zcela výjimečné události, kdy po vydatných deštích proniklo do nádrže extrémní množství prvoků ze skupiny obrněnek (Dinophyta). Ty pak vytvořily povlak postupující s proudem vody po nádrži. Jev byl pozorován zhruba měsíc. Doposud nebyly zjištěny sladkovodní obrněnky (na rozdíl od mořských), které by produkovaly toxiny nebezpečné pro lidský organismus, a tak k přímému ohrožení zdraví koupajících se osob nedošlo. Ohrožena nebyla ani výroba pitné vody z nádrže.
The Seč valley reservoir serves as a retention area during floods, as a source of drinking water and in recent decades as an important recreational area. Due to eutrophication, cyanobacterial blooms have repeatedly occurred here. In July 2024, a highly exceptional event occurred when, after heavy rains, an extreme amount of protozoa from the group of giant nematodes (Dinophyta) entered the reservoir. They then formed a coating that progressed with the flow of water through the reservoir. The phenomenon was observed for about a month. So far, freshwater Dinoflagellates (as opposed to marine Dinoflagellates) have not been found to produce toxins dangerous to the human body, so there has been no direct threat to the health of bathers. Nor has the production of drinking water from the reservoir been compromised.
- MeSH
- Dinoflagellata * imunologie MeSH
- kvalita vody MeSH
- lidé MeSH
- mikrobiologie vody MeSH
- vodní zdroje * MeSH
- Check Tag
- lidé MeSH
- MeSH
- pneumologie MeSH
- tuberkulóza MeSH
- virologie MeSH
- Publikační typ
- biografie MeSH
- osobní vyprávění MeSH
Tento příspěvek se snaží poukázat na šíři problematiky legionel a přispět k jejímu porozumění. Vysvětluje nutnost jejího chápání v širších souvislostech a účel použití ukazatelů Legionella spp. a Legionella pneumophila, které nelze náhodně ani stabilně zaměnit jeden za druhý, protože oba mají odlišnou funkci. Jakákoliv šetření (ať už se jedná o posouzení rizik vnitřního vodovodu, o epidemiologické šetření nebo o výzkumnou studii) a hodnocení se musí provádět s jasně daným cílem a vhodně zvolenými analytickými metodami.
This paper seeks to highlight the scope of the Legionella issue and contribute to its better understanding. It explains the necessity of perceiving it in a broader context and the purpose of using the indicators Legionella spp. and Legionella pneumophila, which cannot be randomly confused or stably substituted for each other, as both have different functions. Any investigation (whether it is domestic distribution system risk assessment, an epidemiological investigation or a research study) and evaluation must be carried out with a clear objective and using analytical methods appropriately chosen for that purpose.
This paper introduces a novel neutron production system for Boron Neutron Capture Therapy (BNCT) that employs a lithium beam in inverse kinematics to generate forward-directed neutrons through the 7Li (p,n)7Be reaction. The system utilizes a thin polypropylene target and an optimized beam configuration to achieve high neutron yield and precise directional control. A tape target mechanism is incorporated to effectively manage thermal loads, ensuring stable and reliable operation. The proposed system could offer substantial advantages over conventional neutron sources, including enhanced neutron directionality and a reduced shielding requirement. This approach increases the potential for precise tumor targeting while minimizing exposure to surrounding healthy tissues, paving the way for a more accessible and efficient BNCT treatment option.
- Publikační typ
- časopisecké články MeSH
Cancer represents one of the most important and often fatal threats in the human population. Regarding the natural products, the purine scaffold appears in the purine bases in nucleic acids. Purine and its natural derivatives display a number of pharmacological effects. Previous investigations revealed that different compounds bearing the purine scaffold in their molecules belong to a group of potent agents for cancer treatment. Therefore, this review focuses on summarizing recently designed agents for potential cancer treatment bearing the purine scaffold as the key structural motif in the molecules. The reviewed structures clearly show the advantages and disadvantages of different substituents of the key scaffold that affect the final cytotoxic effects of the studied structures. The structure-activity relationship analysis shows a summary of different but potent compounds mentioned in this review and identifies the compounds receiving priority importance due to their high cytotoxicity and exceptional physicochemical characteristics. The effects of metal coordination, the formation of convenient conjugated molecules, and supramolecular self-assembly resulting in the production of biologically active nanovesicles and other nanoassemblies are also demonstrated. The reviewed original studies clearly showed the possible advantages of (a) metal ion coordination, (b) the formation of conjugates, and (c) designing smart and biocompatible nanoassemblies for biological activity in comparison with the characteristics of the parent compounds. This review is based on the most recent articles published in the last two years, 2023-2024, and it represents work with a highly interdisciplinary nature. Even if these original articles are not too numerous within the given period, the investigations published therein have clearly documented the importance of the purine scaffold in pharmacology and in medicinal and supramolecular chemistry.
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
