1st ed. 270 s.
- MeSH
- Phosphocreatine MeSH
- Publication type
- Congress MeSH
- Conspectus
- Farmacie. Farmakologie
- NML Fields
- farmacie a farmakologie
- biochemie
Opísaný je prípad akútnej rubeolovej encefalitídy u 16ročného chlapca, ktorý ochorel v priebehu epidémie rubeoly v Košiciach v roku 1995. Prvé prejaiavy postihnutia nervového systému (kŕče a bezvedomie) sa objavili na 3. deň trvania ochorenia s typickými prejavmi rubeoly. V likvore boli pri prijatí zistené zmeny charakteristické pre zápalové postihnutie. CT vyšetrením boli odhalené príznaky edému mozgu. Okrem podávania kortikoidov, antikonvulzív, antipyretík a intravenózneho 7S-imunoglobulinu sme od 2. dňa hospitalizácie aplikovali aj kreatínfosfát. Iniciálne sme podali 2 g, potom každých 12 hodín 1 g i.v. po dobu 3 dní. Po 2 dňoch tejto liečby sa stav výrazne zlepšil. Kŕče prestali, došlo k obnoveniu vedomia. Prechodne však bola prítomná neocerebellárna symptomatológia, ktorá v rekonvalescencii úplne vymizla. Hoci kŕče a bezvedomie sa povzáujú pri rubeolovej encefalitíde za nepriaznivé prognostické znaky, po liečbe, v ktorej sme prvýkrát použili aj kreatínfosfát, došlo k íiplnému uzdraveniu bez akýchkolvek následkov. Domievame sa preto, že štúdium významu podávania kreatínfosfátu pri závažných infekciách CNS si zaslúži dalšiu pozornosť.
The authors describe acute rubella encephalitis in a 16 year old boy who fell ill during a rubella epidemic in Košice in 1995. The first signs of nervous system affection (convulsion, unconsciousness) appeared on the 3rd day of the illness with typical rubella signs. At admission, the changes in cerebrospinal fluid characteristic for the inflammatory affection were found. The computed tomographic scan revealed signs of cerebral edema. In addition to corticosteroid, anticonvulsive and antipyretic therapy, 7S-immunoglobulins and from the second day of hospitalization also creatine-phosphate were used. Initially 2 g were applied, then every 12 hours 1 g i.v. for a period of 3 days. The condition significantly improved after 2 days of this therapy. The spasms ceased, the patient regained consciousness. Temporarily, however, neocerebellar symptomatology was present, but it disappeared completely in convalescence. Although convulsions and coma in encephalitis are considered to be unfavorable prognostic signs, complete recovery was observed after the therapy in which creatine-phosphate was used for the first time. Therefore we suppose that the study of administering creatine-phosphate in cases of severe CNS infections deserves further attention.
- MeSH
- Encephalitis drug therapy physiopathology virology MeSH
- Phosphocreatine therapeutic use MeSH
- Drug Therapy, Combination MeSH
- Humans MeSH
- Adolescent MeSH
- Emergencies MeSH
- Rubella diagnosis drug therapy complications MeSH
- Check Tag
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Publication type
- Case Reports MeSH
- Keywords
- NEOTON,
- MeSH
- Phosphocreatine pharmacology physiology therapeutic use MeSH
- Myocardial Infarction drug therapy MeSH
- Humans MeSH
- Oxidative Phosphorylation MeSH
- Check Tag
- Humans MeSH
- Keywords
- NEOTON (ALFA SCHIAPPARELLI WASSERMANN, ITÁLIE),
- MeSH
- Phosphocreatine therapeutic use MeSH
- Heparin analogs & derivatives therapeutic use MeSH
- Myocardial Infarction drug therapy prevention & control MeSH
- Humans MeSH
- Prospective Studies MeSH
- Streptokinase analogs & derivatives therapeutic use MeSH
- Thrombolytic Therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Multicenter Study MeSH
