Electrogram
Dotaz
Zobrazit nápovědu
- MeSH
- angiografie MeSH
- biomedicínský výzkum MeSH
- dospělí MeSH
- elektrokardiografie metody přístrojové vybavení MeSH
- lidé středního věku MeSH
- lidé MeSH
- počítače MeSH
- převodní systém srdeční patofyziologie MeSH
- senioři MeSH
- srdeční arytmie diagnóza MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- srovnávací studie MeSH
The aim of this study was to clarify whether administration of antipsychotic perphenazine contributes to the electrophysiological changes of the isolated heart. Fourteen adult male Wistar rats were divided into two groups. Langendorff hearts were perfused with Krebs-Henseleit solution at constant pressure (85 mmHg) and 37 °C (CaCl2, 1.2 mM). The electrogram was recorded by touch-free method. The hearts of the first group were exposed to 3.10-5 M perphenazine, the hearts of the second group to 3.10-8 M perphenazine. The incidence of arrhythmias and the heart rate and QT interval changes were studied on electrogram during 30 min periods of control, the first perphenazine administration, washout, and the second drug administration. Perphenazine administration significantly prolonged QT (p < 0.001) and QTc (p < 0.05) in group 1. In group 2, QT and QTc prolongation was less pronounced (p < 0.05). A number of arrhythmias appeared, from single premature ventricular complexes to more severe ones in both groups. The heart rate changes were non-significant. We conclude that although phenothiazines are still medicaments of choice in certain psychoses, their cardiovascular side effects should be always taken in consideration.
- Klíčová slova
- prodloužení QT,
- MeSH
- elektrofyziologické techniky kardiologické MeSH
- perfenazin * farmakologie MeSH
- potkani Wistar MeSH
- preparace izolovaného srdce MeSH
- srdce MeSH
- srdeční arytmie MeSH
- srdeční elektrofyziologie * MeSH
- srdeční frekvence MeSH
- srdeční komory MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
Studie ČSAV ; č. 8
113 s. : il.
Three-dimensional electrogram was used for analysis of ischemia manifestation in isolated hearts. Three parameters based on spherical coordination system were used in this study – amplitude of electrical heart vector, its azimuth and elevation. The parameters were presented as a trend. This approach reflected ischemic changes in a manner which can be easily observed and evaluated. Ischemia was analysed in seven isolated hearts of New Zealand white rabbits. It was found that (a) ischemia changes heart electric vector, (b) ischemic preconditioning has a protective effect, and (c) both of these findings can be clearly observed by the proposed method.
- MeSH
- akční potenciály MeSH
- elektrofyziologické techniky kardiologické MeSH
- financování organizované MeSH
- interpretace obrazu počítačem MeSH
- ischemická choroba srdeční diagnóza prevence a kontrola MeSH
- ischemické přivykání MeSH
- králíci MeSH
- modely kardiovaskulární MeSH
- modely nemocí na zvířatech MeSH
- prediktivní hodnota testů MeSH
- vektorkardiografie MeSH
- zobrazování trojrozměrné MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- zvířata MeSH
- Publikační typ
- přehledy MeSH
Most cardiac arrhythmias can be classified as atrial flutter, focal atrial tachycardia, or atrial fibrillation. They have been usually treated using drugs, but catheter ablation has proven more effective. This is an invasive method devised to destroy the heart tissue that disturbs correct heart rhythm. In order to accurately localise the focus of this disturbance, the acquisition and processing of atrial electrograms form the usual mapping technique. They can be single potentials, double potentials, or complex fractionated atrial electrogram (CFAE) potentials, and last ones are the most effective targets for ablation. The electrophysiological substrate is then localised by a suitable signal processing method. Sample Entropy is a statistic scarcely applied to electrograms but can arguably become a powerful tool to analyse these time series, supported by its results in other similar biomedical applications. However, the lack of an analysis of its dependence on the perturbations usually found in electrogram data, such as missing samples or spikes, is even more marked. This paper applied SampEn to the segmentation between non-CFAE and CFAE records and assessed its class segmentation power loss at different levels of these perturbations. The results confirmed that SampEn was able to significantly distinguish between non-CFAE and CFAE records, even under very unfavourable conditions, such as 50% of missing data or 10% of spikes.
- MeSH
- elektrofyziologické techniky kardiologické * MeSH
- entropie * MeSH
- fibrilace síní diagnóza MeSH
- katetrizační ablace MeSH
- lidé MeSH
- srdeční elektrofyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- angiografie MeSH
- biomedicínský výzkum MeSH
- dospělí MeSH
- elektrokardiografie metody přístrojové vybavení MeSH
- lidé středního věku MeSH
- lidé MeSH
- počítače MeSH
- převodní systém srdeční patofyziologie MeSH
- senioři MeSH
- srdeční arytmie diagnóza MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- srovnávací studie MeSH
