OBJECTIVE AND BACKGROUND: The 10-item Edinburgh Postnatal Depression Scale (EPDS) is a widely-used screening measure for postnatal depression. Factor analysis studies have suggested an embedded sub-scale could be used for screening for anxiety disorders. The current investigation sought to replicate and extend a recent study supporting this assertion. METHODS: A cross-sectional design. EPDS data were collected at up to two years postpartum. Confirmatory factor analysis, correlational and distributional characteristics of the measure were examined. Participants were a large sample (N = 985) of postpartum women in the Czech Republic. RESULTS: Factor structure findings substantially replicated the models evaluated by Della Vedova et al. (2022). Bifactor models, however, offered a better fit to data. A general factor of depression explained most of the variance in data in most models compared to embedded sub-scales across models. CONCLUSION: The model proposed by Della Vedova et al. (2022) offered an excellent fit to data. However, the findings from the bifactor modelling suggest the dominance of a general factor of depression which indicates the potential application of an embedded anxiety sub-scale for screening may be overstated.

• MeSH
• Adult MeSH
• Factor Analysis, Statistical MeSH
• Humans MeSH
• Young Adult MeSH
• Depression, Postpartum * diagnosis   psychology   MeSH
• Cross-Sectional Studies MeSH
• Psychiatric Status Rating Scales * standards   MeSH
• Psychometrics MeSH
• Reproducibility of Results MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Young Adult MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Czech Republic MeSH

OBJECTIVES: This study aimed to assess the effectiveness of Comprehensive Geriatric Assessment (CGA) compared to standard of care in improving pain, physical function, and stiffness in older adults with knee osteoarthritis (OA) over six months. Secondary outcomes included multidimensional frailty and quality of life. DESIGN: An exploratory, multicentre, randomized controlled trial (RCT). SETTING: Five European geriatric centres in Italy, Germany, Turkiye and the Czech Republic. PARTICIPANTS: Seventy older adults (mean age 76.1 ± 6.8 years; 80% female) with knee OA (Kellgren-Lawrence Grades 1-2) were randomized into two groups: CGA (n = 35) or standard of care (n = 35). INTERVENTION: The CGA group underwent a multidimensional geriatric assessment and intervention, identifying impairments and tailoring interventions accordingly, while the control group received standard of care. MAIN OUTCOME MEASURES: The primary endpoint was improvement in pain, stiffness, and functional limitations measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) over six months. Secondary outcomes included changes in multidimensional frailty (Multidimensional Prognostic Index, MPI), quality of life (SF-36), and adherence to interventions. RESULTS: The CGA group showed a non-significant improvement in total WOMAC scores (-4.49 ± 3.40, p = 0.19), with slight reductions in pain (-1.12 ± 0.96) and functional limitations (-3.26 ± 2.21). MPI slightly improved (-0.02 ± 0.04, p = 0.69), but no significant changes were observed in SF-36 scores. No falls, hospitalizations, or severe adverse events were reported. CONCLUSIONS: CGA may offer potential benefits for managing knee OA in older adults, particularly for pain and function, though statistical significance was not achieved. Larger studies with longer follow-up are warranted to confirm these findings. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05659979.

• MeSH
• Osteoarthritis, Knee * therapy   physiopathology   diagnosis   MeSH
• Geriatric Assessment * methods   MeSH
• Quality of Life MeSH
• Humans MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Check Tag
• Humans MeSH
• Male MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Multicenter Study MeSH
• Randomized Controlled Trial MeSH

OBJECTIVE: This study aimed to evaluate the reliability and validity of the Binge Eating Disorder Screener-7 (BEDS-7) across 42 countries and 26 languages, assessing its reliability and validity as a screening tool for binge-eating disorder (BED) in diverse cultural contexts. Specifically, it sought to enhance early recognition of BED symptoms in primary care settings globally, contributing to a standardized framework for assessing BED. METHOD: The International Sex Survey, a cross-sectional online study, was conducted in 42 countries and 26 languages. A diverse community sample of 82,243 participants, aged 18 years or older, completed the BEDS-7 and measures of sexuality, mental health, substance use, and sociodemographic characteristics. Confirmatory factor analyses and tests of measurement invariance were employed to evaluate the reliability and validity of the BEDS-7 across languages, countries, genders, and sexual orientations. RESULTS: The BEDS-7 demonstrated scalar factorial invariance across languages and countries, indicating consistent factor loadings and item intercepts. In contrast, the screener showed residual invariance across gender and sexual orientation groups, supporting its robustness across these demographics. Kruskal-Wallis tests revealed significant differences in BED symptoms across languages, countries, genders, and sexual orientations, with the highest BED scores observed among queer, pansexual, and gender-diverse individuals. The BEDS-7 also demonstrated adequate reliability (Cronbach's alpha > 0.80) and moderate criterion validity. DISCUSSION: The findings provide further evidence of the reliability and validity of the BEDS-7 as a potential screening tool for identifying probable cases of BED globally, facilitating early intervention in primary care settings.

• MeSH
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Cross-Sectional Studies MeSH
• Surveys and Questionnaires MeSH
• Psychiatric Status Rating Scales * standards   MeSH
• Psychometrics MeSH
• Reproducibility of Results MeSH
• Cross-Cultural Comparison * MeSH
• Binge-Eating Disorder * diagnosis   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Validation Study MeSH

BACKGROUND AND AIMS: Despite the last decade's significant development in the scientific study of work addiction/workaholism, this area of research is still facing a fundamental challenge, namely the need for a valid and reliable measurement tool that shows cross-cultural invariance and, as such, allows for worldwide studies on this phenomenon. METHODS: An initial 16-item questionnaire, developed within an addiction framework, was administered alongside job stress, job satisfaction, and self-esteem measures in a total sample of 31,352 employees from six continents and 85 cultures (63.5% females, mean age of 39.24 years). RESULTS: Based on theoretical premises and psychometric testing, the International Work Addiction Scale (IWAS) was developed as a short measure representing essential features of work addiction. The seven-item version (IWAS-7), covering all seven components of work addiction, showed partial scalar invariance across 81 cultures, while the five-item version (IWAS-5) showed it across all 85 cultures. Higher levels of work addiction on both versions were associated with higher job stress, lower job satisfaction, and lower self-esteem across cultures. The optimal cut-offs for the IWAS-7 (24 points) and IWAS-5 (18 points) were established with an overall accuracy of 96% for both versions. DISCUSSION AND CONCLUSIONS: The IWAS is a valid, reliable, and short screening scale that can be used in different cultures and languages, providing comparative and generalizable results. The scale can be used globally in clinical and organizational settings, with the IWAS-5 being recommended for most practical and clinical situations. This is the first study to provide data supporting the hypothesis that work addiction is a universal phenomenon worldwide.

• MeSH
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Behavior, Addictive * diagnosis   MeSH
• Occupational Stress diagnosis   MeSH
• Job Satisfaction * MeSH
• Surveys and Questionnaires standards   MeSH
• Psychiatric Status Rating Scales standards   MeSH
• Psychometrics * standards   instrumentation   MeSH
• Reproducibility of Results MeSH
• Self Concept MeSH
• Cross-Cultural Comparison * MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Validation Study MeSH

STUDY OBJECTIVES: Sleep is essential for proper function of the mind and body. Studies report the effect of sleep problems on cognition but focus on only a single or limited number of sleep indicators or on clinical populations (e.g., sleep apnea), and/or provide only cross-sectional results. This study examined cross-sectional and longitudinal associations between multidimensional assessment of sleep health and cognitive function. METHODS: 3398 adults (Mage=56years) provided self-reported sleep and objective cognitive data for the Midlife in the United States study. A subsample of 2119 participants also provided sleep and cognitive data at follow-up approximately 9years later. A multidimensional, composite measure of sleep health composed of regularity, satisfaction, alertness, efficiency, and duration based on the Ru-SATED model was utilized (higher score=better sleep health) to evaluate self-reported sleep, and cognitive function was assessed using the Brief Test of Adult Cognition by Telephone. RESULTS: Cross-sectionally, better sleep health was associated with better cognition (B=0.121, SE=0.017, p<.001). This relationship remained significant even after adjusting for sociodemographic and health covariates (B=0.039, SE=0.014, p=.006). Longitudinally, improvement in sleep health from baseline to follow-up was associated with better cognitive performance at follow-up (B=0.031, SE=0.011, p=.004); however, this relationship did not remain significant after adjusting for covariates (B=0.015, p=.139). CONCLUSION: Findings suggest better sleep health measured across multiple domains is associated with higher cognitive function. Future studies may want to examine potential mechanisms by which better sleep health relates to better cognitive function over time, such as reduction in stress or inflammation.

• MeSH
• Adult MeSH
• Cognition * physiology   MeSH
• Sleep Quality * MeSH
• Middle Aged MeSH
• Humans MeSH
• Longitudinal Studies MeSH
• Cross-Sectional Studies MeSH
• Sleep * physiology   MeSH
• Self Report MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• United States MeSH

OBJECTIVE: To determine the relationships between psilocybin dose, psychedelic experiences, and therapeutic outcome in treatment-resistant depression. METHODS: For treatment-resistant depression, 233 participants received a single dose of 25, 10, or 1 mg of COMP360 psilocybin (a proprietary, pharmaceutical-grade synthesized psilocybin formulation, developed by the sponsor, Compass Pathfinder Ltd.) with psychological support. The resulting psychedelic experience (Five-Dimensional Altered States of Consciousness questionnaire [5D-ASC] and Emotional Breakthrough Inventory [EBI]) were measured. These proximal variables and outcome 3 weeks post-administration (change in Montgomery-Åsberg Depression Rating Scale [MADRS]) were explored using correlation analysis. RESULTS: The mean intensity of psychedelic effects was dose-related, but distributions of scores for different doses overlapped considerably. Depression response correlated with select aspects of the psychedelic experience overall and for individual doses. At the 25 mg dose, 5D-ASC dimensions Oceanic Boundlessness (Pearson correlation coefficient r = -0.508) and Visual Restructuralization (r = -0.516), and EBI (r = -0·637) were the variables with the strongest correlation to the Week 3 change from Baseline in MADRS score. LIMITATIONS: The existence of correlation does not establish causation and exploratory findings require further replication, preferably in larger independent samples. CONCLUSIONS: The intensity of psychedelic experience overlaps widely across doses and mitigates the risk of unblinding to dose. Correlations between psychedelic experience and outcome suggest specificity in psilocybin's mechanism of action. Quality and intensity of psychedelic experience may be a measure of pharmacodynamic effect and reveal an effective dose response phenomenon for single oral doses.

• MeSH
• Depressive Disorder, Treatment-Resistant * drug therapy   MeSH
• Depressive Disorder, Major drug therapy   MeSH
• Adult MeSH
• Double-Blind Method MeSH
• Hallucinogens * administration & dosage   pharmacology   MeSH
• Middle Aged MeSH
• Humans MeSH
• Psilocybin * pharmacology   administration & dosage   MeSH
• Psychiatric Status Rating Scales MeSH
• Treatment Outcome MeSH
• Dose-Response Relationship, Drug MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Randomized Controlled Trial MeSH

Aim: Pre- and postnatal depressive symptoms may have a negative impact on maternal mental health and on mother-child bonding and interactions. The aim of the study was to assess the role of various factors on women's mental health during pregnancy and to evaluate the role of selected health care strategies in preventing mental health issues before and after delivery, with an emphasis on the development of fear of childbirth and postnatal depression. Design: A quantitative study. Methods: A non-standardized 125-item questionnaire was developed with questions about pregnancy, delivery, and puerperium, including questions about mental health, physical health, and different forms of care received before, during and after delivery, as well as personal satisfaction with these forms of care was developed. The Edinburgh Postnatal Depression Scale (EPDS) was used to assess depressive symptoms after delivery. Enrollment was purposive, and 361 women between six weeks and nine months postpartum were addressed. Statistical analysis was performed using SASD 1.5.8. Results: Fear of childbirth was found to be positively correlated with mental health issues during pregnancy and with the decision to have a cesarean delivery. No correlation was found between fear of childbirth and antenatal class attendance or trust in health professionals. Postnatal depression was positively correlated with mental health issues during pregnancy and with receiving information from the midwife about psychological changes during pregnancy, but negatively correlated with satisfaction with mother-infant bonding after delivery and with having a birth plan. No correlation was found between postnatal depression and sociodemographic characteristics or physical complications during pregnancy. Conclusion: Mental health issues during pregnancy and postpartum can negatively affect the quality of mother-child interactions and family interactions. It is crucial to pay attention to preventive measures, to educate both midwives and gynecologists about the importance of mental health during pregnancy, and to include mental health interventions during pregnancy in antenatal classes. It is important to pay attention to mother-infant bonding straight in the delivery ward as it is strongly associated with postnatal depression in the mother and well-being of the child.

• Keywords
• Edinburská škála postnatální deprese,
• MeSH
• Mental Health MeSH
• Clinical Studies as Topic methods   MeSH
• Humans MeSH
• Depression, Postpartum * psychology   MeSH
• Parturition psychology   MeSH
• Surveys and Questionnaires MeSH
• Psychiatric Status Rating Scales * MeSH
• Fear MeSH
• Pregnancy psychology   MeSH
• Mother-Child Relations psychology   MeSH
• Check Tag
• Humans MeSH
• Pregnancy psychology   MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH

BACKGROUND AND OBJECTIVE: Stone size has traditionally been measured in one dimension. This is reflected in most of the literature and in the EAU guidelines. However, recent studies have shown that multidimensional measures provide better prediction of outcomes. METHODS: We performed a systematic review and meta-analysis of the prognostic accuracy of measures of stone size (PROSPERO reference CRD42022346967). We considered all studies reporting prognostic accuracy statistics on any intervention for kidney stones (extracorporeal shockwave lithotripsy [ESWL], ureterorenoscopy [URS], or percutaneous nephrolithotomy [PCNL]; Population) using multiplane measurements of stone burden (area in mm2 or volume in mm3; Intervention) in comparison to single-plane measurements of stone burden (size in mm; Intervention) for the study-defined stone-free rate (Outcome) in a PICO-framed question. We also assessed complication rates (overall and by Clavien-Dindo grade) and the operative time as secondary outcomes. Searches were made between 1970 and August 2023. We used the DeLong method to compare receiver operating characteristic (ROC) curves. KEY FINDINGS AND LIMITATIONS: Of 24 studies included in the review, 12 were eligible for comparative analysis with the DeLong test following meta-analysis of prognostic accuracy. For prediction of stone-free status, the area under the ROC curve (AUC) was significantly higher for stone volume than for stone size (0.71 vs 0.67; p < 0.001). Subanalyses confirmed this for ESWL and URS, but not for PCNL. For URS, the AUC was also significantly higher for stone area than for stone size (0.79 vs 0.77; p < 0.001). Throughout all analyses, there was no difference in AUC between stone area and stone volume. There was high risk of bias for all analyses apart from the URS subanalyses. CONCLUSIONS AND CLINICAL IMPLICATIONS: According to the limited data currently available, stone-free rates are predicted with significantly higher accuracy using multidimensional measures of stone burden in comparison to a single linear measurement. PATIENT SUMMARY: We reviewed different ways of measuring the size of stones in the kidney or urinary tract and compared their accuracy in predicting stone-free rates after treatment. We found that measurement of the stone area (2 dimensions) or stone volume (3 dimensions) is better than stone diameter (1 dimension) in predicting stone-free status after treatment.

• Publication type
• Journal Article MeSH
• Review MeSH

PURPOSE: The Core Outcome Measures Index (COMI) is a short, multidimensional instrument translated into several languages that covers five domains recommended in the assessment of outcome in patients with low-back and neck pain. The purpose of this study was to cross-culturally adapt the COMI from English to Czech language and to test the face and construct validity and reproducibility of its results in patients with low-back and neck pain. METHODS: Participants (n = 125) were included from primary and secondary care. The participants reported moderate pain and disability levels. All participants filled in the COMI forms before and after surgery. Descriptive statistics, Wilcoxon paired test, Crombach's alpha, principal component analysis and information entropy calculation were used. RESULTS: The instrument was successfully forward and back-translated. It can be seen that the questionnaire applied as part of our intervention study produces answers with a sufficient degree of variability and with a satisfactory degree of representation of extreme values. It can be also seen that the questionnaire can diagnose an objectively occurring change associated with the surgeon within the intervention procedure. Our other findings support the idea of ​​a possible reduction in the number of questions that measure the same latent variable. Our investigations also showed that it is possible to reduce the range of the point scale of the perception of pain to 5 degrees of intensity and thus unify the range with the other questions. CONCLUSION: The Czech COMI shows acceptable properties and is thus suitable to use as a short instrument for measuring important domains in patients with low-back and neck pain.

• MeSH
• Neck Pain * diagnosis   MeSH
• Adult MeSH
• Outcome Assessment, Health Care methods   MeSH
• Middle Aged MeSH
• Humans MeSH
• Low Back Pain * diagnosis   MeSH
• Pain Measurement methods   MeSH
• Disability Evaluation MeSH
• Surveys and Questionnaires standards   MeSH
• Reproducibility of Results MeSH
• Aged MeSH
• Cross-Cultural Comparison * MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Czech Republic MeSH

PROBLEM: Up to 75 % of at-risk perinatal women do not receive treatment in Czechia. BACKGROUND: Pregnant women with mental health difficulties are more likely to undergo less controversial nonpharmaceutical treatment during pregnancy, but structural and psychological barriers interfere with their capacity to seek professional help. AIM: We tested the effectiveness of the telephone-based peer support intervention Mom Supports Mom (MSM) in Czech pregnant women at risk of mental disorder. METHODS: The Edinburgh Postnatal Depression Scale (EPDS) was used to assess risk in women (EPDS ≥ 10). Women at risk were randomized into two groups; the intervention group received the MSM, while the control group received the care as usual, which did not contain any psychological support intervention. One month after completing the EPDS, the women's mental statuses were again measured and compared, this time with data before and after the intervention, using the Perinatal Anxiety Screening Scale (PASS) to measure anxiety, the EPDS to measure depression, the Prenatal Psychosocial Profile (PPP) to measure stress, and the Prenatal Attachment Inventory - Revised (PAI-R) to measure attachment. The trial was registered under the name Pregnancy without psychosocial stress (ClinicalTrials.gov ID NCT04853693). FINDINGS: A total of 167 women were included in the study and randomized into two groups. Depressive symptoms did not decrease (Cohen ́s d; 95 % CI = 0.48; 0.17-0.79; p = .002), but levels of anxiety (Cohen ́s d; 95 % CI = 0.44; 0.13-0.75; p = .005) and psychosocial stress (Cohen ́s d; 95 % CI = 0.55; 0.20-0.82; p = .002) were reduced in women in the intervention group compared with women in the control. In addition, prenatal attachment increased among intervened women (Cohen ́s d; 95 % CI = 0.48; 0.17-0.79; p = .002). DISCUSSION: The telephone-based peer support intervention MSM is effective in reducing stress and anxiety and increasing prenatal attachment but does not reduce depression among high-risk women.

• MeSH
• Adult MeSH
• Humans MeSH
• Mothers psychology   MeSH
• Prenatal Care methods   MeSH
• Psychiatric Status Rating Scales MeSH
• Social Support * MeSH
• Pregnancy MeSH
• Pregnant People MeSH
• Peer Group * MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Pregnancy MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Randomized Controlled Trial MeSH
• Geographicals
• Czech Republic MeSH