• MeSH
• Rheumatic Diseases MeSH
• Publication type
• Periodical MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• revmatologie

• MeSH
• Dermatology MeSH
• Venereology MeSH
• Publication type
• Periodical MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• dermatovenerologie
• dermatovenerologie

• MeSH
• Sexually Transmitted Diseases MeSH
• Publication type
• Periodical MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• dermatovenerologie
• dermatovenerologie

• MeSH
• Bombyx genetics   MeSH
• Glycoproteins genetics   isolation & purification   MeSH
• Genes, Insect genetics   MeSH
• Lepidoptera genetics   MeSH
• Molecular Sequence Data MeSH
• Animals MeSH
• Check Tag
• Animals MeSH

• Publication type
• Meeting Abstract MeSH

• Publication type
• Abstracts MeSH

Expresní a funkční studie regulačních faktorů ribozomální transkripce prováděné na souboru leukemických buněčných linií a na leukocytech z krve pacientů s krevními malignitami. Charakterizace specifického granulocytárního proteinu p25. I. Exprese, interakce a posttranslační modifikace proteinů regulujících transkripci ribozomálního genu v krevních buňkách. II. Studium lidského granulocytárního proteinu p25. The Ribosomal Gene Transcription in Transformed Blood Cells: Expreáion and Interaction of the Regulatory Proteins and their Posttranslational Modifications. The Study of the HumanGranulocytic Protein p25.; Expression and function studies of transcription factors invelved in ribozomal gene transcription performed on a set of leukemic cell lines,in vitro stimulated lamphocytes and blood cells of leukemic patients. Characterization of the specific granulocytic protein p25.

• MeSH
• Lymphocytes MeSH
• Cell Transformation, Neoplastic MeSH
• Reverse Transcriptase Polymerase Chain Reaction methods   MeSH
• Gene Expression Regulation, Neoplastic MeSH
• DNA, Ribosomal MeSH
• RNA, Ribosomal MeSH
• RNA Polymerase I MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• hematologie a transfuzní lékařství
• biologie
• NML Publication type
• závěrečné zprávy o řešení grantu IGA MZ ČR

• Publication type
• Abstracts MeSH

AIM: The aim of this study was to determine the antifungal activity of titanium dioxide activated by indoor light on Czapek Yeast Agar (CYA). METHODS: The agar plate method was used and titania P25 (Evonik) was added to the medium in the amount of 20 g.dm(-3). The control experiments without titania were also carried out. The water activity (a(w)) of the basal media was adjusted to 0.999, 0.997, 0.975, 0.950, 0.900 and 0.850 with sodium chloride. The photoactivity of titania was tested for six strains of potentially pathogenic fungi: Aspergillus versicolor (WB130, W11), Stachybotrys chartarum (STA1), Pseudallescheria boydii (AP25), Pseudallescheria ellipsoidea (ZUT1 2), Scedosporium apiospermum (ZUT1 1), Scedosporium aurantiacum (ZUT4BIS). After inoculation with fungal spore suspensions, one part of CYA plates was incubated in dark, while another part was daily exposed to indoor light for 12 hours per day.The plates were incubated at 25°C for 10 days. The daily growth rates (mm x day(-1)) were calculated from the linear regression equation. RESULTS: The CYA supplementation with titanium dioxide for different availability of water resulted in the decrease of fungal growth rates in dark and under irradiation. The lowest and the highest rates of daily growth were obtained in the presence and absence of titania for the low and high water activity (0.900 a(w) and 0.999 a(w)), respectively. CONCLUSIONS: Fungi did not grow on all examined media with the lowest water activity (a(w) ≤ 0.850) which confirmed necessity of water for their growth. The fungi Pseudallescheria-Scedosporium were the most sensitive to titania and water activity, while the strains of Aspergillus versicolor were the most resistant to the presence of titania and lack of water. It has been shown that the lack of accessible water resulted in the strongest action of titanium dioxide both in dark and under irradiation. For the lowest amount of accessible water irradiation of titania resulted in complete inhibition of fungal growth. While, under dark conditions, titania presence enhanced the growth of persistent fungi, i.e., Aspergillus versicolor. It is assumed that these fungi could obtain water from the water-rich titania surface.

• MeSH
• Antifungal Agents pharmacology   MeSH
• Fungi drug effects   MeSH
• Humans MeSH
• Lighting * MeSH
• Titanium pharmacology   MeSH
• Water administration & dosage   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

We report the results of linkage analysis in a large American family of Czech descent with dominantly inherited "pure" essential tremor (ET) and genetic anticipation. Genetic loci on chromosome 2p22-p25 establish linkage to this region with a maximum LOD score (Zmax) = 5.92 for the locus, D2S272. Obligate recombinant events place the ETM gene in a 15-cM candidate interval between the genetic loci D2S168 and D2S224. Repeat expansion detection analysis suggests that expanded CAG trinucleotide sequences are associated with ET. These findings will facilitate the search for an ETM gene and may further our understanding of the human motor system.

• MeSH
• X Chromosome MeSH
• Chromosome Aberrations genetics   MeSH
• Chromosome Disorders MeSH
• Child MeSH
• Adult MeSH
• Phenotype MeSH
• Genetic Linkage genetics   MeSH
• Haplotypes genetics   MeSH
• Middle Aged MeSH
• Humans MeSH
• Chromosomes, Human, Pair 2 genetics   MeSH
• Adolescent MeSH
• Pedigree MeSH
• Aged MeSH
• Severity of Illness Index MeSH
• Tremor diagnosis   genetics   MeSH
• Trinucleotide Repeats genetics   MeSH
• Check Tag
• Child MeSH
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Aged MeSH
• Publication type
• Journal Article MeSH
• Research Support, U.S. Gov't, P.H.S. MeSH
• Geographicals
• Czech Republic MeSH
• United States MeSH