Relational database
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1st ed. xv, 451 s.
- Klíčová slova
- Databáze,
- MeSH
- databáze jako téma MeSH
- informační systémy MeSH
- Publikační typ
- monografie MeSH
- Konspekt
- Programování. Software
- NLK Obory
- technika
UNLABELLED: The Plant rDNA database (www.plantrdnadatabase.com) is an open access online resource providing detailed information on numbers, structures and positions of 5S and 18S-5.8S-26S (35S) ribosomal DNA loci. The data have been obtained from >600 publications on plant molecular cytogenetics, mostly based on fluorescent in situ hybridization (FISH). This edition of the database contains information on 1609 species derived from 2839 records, which means an expansion of 55.76 and 94.45%, respectively. It holds the data for angiosperms, gymnosperms, bryophytes and pteridophytes available as of June 2013. Information from publications reporting data for a single rDNA (either 5S or 35S alone) and annotation regarding transcriptional activity of 35S loci now appears in the database. Preliminary analyses suggest greater variability in the number of rDNA loci in gymnosperms than in angiosperms. New applications provide ideograms of the species showing the positions of rDNA loci as well as a visual representation of their genome sizes. We have also introduced other features to boost the usability of the Web interface, such as an application for convenient data export and a new section with rDNA-FISH-related information (mostly detailing protocols and reagents). In addition, we upgraded and/or proofread tabs and links and modified the website for a more dynamic appearance. This manuscript provides a synopsis of these changes and developments. DATABASE URL: http://www.plantrdnadatabase.com.
IRESite is an exhaustive, manually annotated non-redundant relational database focused on the IRES elements (Internal Ribosome Entry Site) and containing information not available in the primary public databases. IRES elements were originally found in eukaryotic viruses hijacking initiation of translation of their host. Later on, they were also discovered in 5'-untranslated regions of some eukaryotic mRNA molecules. Currently, IRESite presents up to 92 biologically relevant aspects of every experiment, e.g. the nature of an IRES element, its functionality/defectivity, origin, size, sequence, structure, its relative position with respect to surrounding protein coding regions, positive/negative controls used in the experiment, the reporter genes used to monitor IRES activity, the measured reporter protein yields/activities, and references to original publications as well as cross-references to other databases, and also comments from submitters and our curators. Furthermore, the site presents the known similarities to rRNA sequences as well as RNA-protein interactions. Special care is given to the annotation of promoter-like regions. The annotated data in IRESite are bound to mostly complete, full-length mRNA, and whenever possible, accompanied by original plasmid vector sequences. New data can be submitted through the publicly available web-based interface at http://www.iresite.org and are curated by a team of lab-experienced biologists.
- MeSH
- databáze nukleových kyselin MeSH
- financování organizované MeSH
- iniciace translace peptidového řetězce MeSH
- iniciační faktory metabolismus MeSH
- internet MeSH
- messenger RNA chemie MeSH
- nepřekládané oblasti chemie MeSH
- plazmidy chemie MeSH
- promotorové oblasti (genetika) MeSH
- regulační sekvence ribonukleových kyselin MeSH
- RNA virová chemie MeSH
- uživatelské rozhraní počítače MeSH
- MeSH
- lidé MeSH
- revize kvality lékařské péče MeSH
- zdravotní pojištění MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- databáze MeSH
1st ed. vii, 280 s.
1st ed., repr. x, 448 s.
- MeSH
- databáze jako téma MeSH
- Publikační typ
- příručky MeSH
- Konspekt
- Informační věda
- NLK Obory
- knihovnictví, informační věda a muzeologie
BACKGROUND AND OBJECTIVE: Obstructive sleep apnoea (OSA) and hyperlipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and prevalence of hyperlipidaemia in patients of the European Sleep Apnea Database (ESADA) cohort. METHODS: The cross-sectional analysis included 11 892 patients (age 51.9 ± 12.5 years, 70% male, body mass index (BMI) 31.3 ± 6.6 kg/m2 , mean oxygen desaturation index (ODI) 23.7 ± 25.5 events/h) investigated for OSA. The independent odds ratio (OR) for hyperlipidaemia in relation to measures of OSA (ODI, apnoea-hypopnoea index, mean and lowest oxygen saturation) was determined by means of general linear model analysis with adjustment for important confounders such as age, BMI, comorbidities and study site. RESULTS: Hyperlipidaemia prevalence increased from 15.1% in subjects without OSA to 26.1% in those with severe OSA, P < 0.001. Corresponding numbers in patients with diabetes were 8.5% and 41.5%, P < 0.001. Compared with ODI quartile I, patients in ODI quartiles II-IV had an adjusted OR (95% CI) of 1.33 (1.15-1.55), 1.37 (1.17-1.61) and 1.33 (1.12-1.58) (P < 0.001), respectively, for hyperlipidaemia. Obesity was defined as a significant risk factor for hyperlipidaemia. Subgroups of OSA patients with cardio-metabolic comorbidities demonstrated higher prevalence of HL. In addition, differences in hyperlipidaemia prevalence were reported in European geographical regions with the highest prevalence in Central Europe. CONCLUSION: Obstructive sleep apnoea, in particular intermittent hypoxia, was independently associated with the prevalence of hyperlipidaemia diagnosis.
- MeSH
- hyperlipidemie epidemiologie MeSH
- kardiovaskulární nemoci epidemiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- obezita epidemiologie MeSH
- obstrukční spánková apnoe epidemiologie MeSH
- polysomnografie MeSH
- prevalence MeSH
- průřezové studie MeSH
- rizikové faktory MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa MeSH
ChannelsDB (http://ncbr.muni.cz/ChannelsDB) is a database providing information about the positions, geometry and physicochemical properties of channels (pores and tunnels) found within biomacromolecular structures deposited in the Protein Data Bank. Channels were deposited from two sources; from literature using manual deposition and from a software tool automatically detecting tunnels leading to the enzymatic active sites and selected cofactors, and transmembrane pores. The database stores information about geometrical features (e.g. length and radius profile along a channel) and physicochemical properties involving polarity, hydrophobicity, hydropathy, charge and mutability. The stored data are interlinked with available UniProt annotation data mapping known mutation effects to channel-lining residues. All structures with channels are displayed in a clear interactive manner, further facilitating data manipulation and interpretation. As such, ChannelsDB provides an invaluable resource for research related to deciphering the biological function of biomacromolecular channels.
- MeSH
- aminokyseliny chemie metabolismus MeSH
- cytochrom P-450 CYP2D6 chemie genetika metabolismus MeSH
- databáze proteinů * MeSH
- eukaryotické buňky cytologie enzymologie MeSH
- exprese genu MeSH
- hydrofobní a hydrofilní interakce MeSH
- iontové kanály chemie genetika metabolismus MeSH
- jaderný pór chemie genetika metabolismus MeSH
- katalytická doména MeSH
- koenzymy chemie metabolismus MeSH
- lidé MeSH
- mutace MeSH
- prokaryotické buňky cytologie enzymologie MeSH
- software * MeSH
- statická elektřina MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
