• MeSH
• neurovědy MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Obory
• neurovědy

• MeSH
• klasifikace MeSH
• transdukce genetická MeSH
• Publikační typ
• příručky MeSH

• Konspekt
• Biochemie. Molekulární biologie. Biofyzika
• NLK Obory
• biochemie
• biologie

BACKGROUND AND PURPOSE: The σ-1 receptor (Sig-1R) agonist cutamesine (SA4503) enhanced functional recovery after experimental stroke with a treatment initiation window of 48 hours and chronic treatment for 28 days. We conducted a phase 2 clinical trial exploring the safety, tolerability, dose range, and functional effects of cutamesine in patients with ischemic stroke. METHODS: Subjects were randomized between 48 and 72 hours after stroke to receive cutamesine 1 mg/d, 3 mg/d, or placebo for 28 days. Effects on safety and function were assessed at baseline, at end of treatment (day 28), and at end of follow-up (day 56). RESULTS: In 60 patients, treatment with both cutamesine dosages was safe and well tolerated without significant differences in numbers of treatment emergent or serious adverse events. No significant effect was observed on the primary efficacy measure (change in National Institutes of Health Stroke Scale from baseline to day 56) or modified Rankin Scale and Barthel Index scores. Post hoc analysis of moderately and severely affected patients (baseline National Institutes of Health Stroke Scale, ≥7 and ≥10) showed greater National Institutes of Health Stroke Scale improvements in the 3 mg/d cutamesine group when compared with placebo (P=0.034 and P=0.038, respectively). A trend toward a higher proportion being able to complete a 10m timed walk was observed for cutamesine-treated subjects. CONCLUSIONS: Cutamesine was safe and well tolerated at both dosage levels. Although no significant effects on functional end points were seen in the population as a whole, greater improvement in National Institutes of Health Stroke Scale scores among patients with greater pretreatment deficits seen in post hoc analysis warrants further investigation. Additional studies should focus on the patient population with moderate-to-severe stroke. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov/show/NCT00639249. Unique identifier: NCT00639249. The EudraCT number is 2007-004840-60 (https://www.clinicaltrialsregister.eu/ctr-search/trial/2007-004840-60/GB).

• MeSH
• časové faktory MeSH
• cévní mozková příhoda patofyziologie   MeSH
• dospělí MeSH
• dvojitá slepá metoda MeSH
• internacionalita MeSH
• ischemie mozku patofyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• obnova funkce fyziologie   MeSH
• piperaziny diagnostické užití   farmakologie   MeSH
• radioizotopy uhlíku diagnostické užití   farmakologie   MeSH
• receptory sigma agonisté   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky, fáze II MeSH
• multicentrická studie MeSH
• práce podpořená grantem MeSH
• randomizované kontrolované studie MeSH

Hand grip strength is one of the most important markers in muscle strength assessment for many reasons. However, its maximal value in kilograms is highly dependent on body size, which may misrepresent results, especially among children. Therefore, correction by body mass index (BMI) can be used as a suitable approach for its objectification. The aims of this study were to create reference values for the grip to BMI ratio and for hand grip strength for children in the Czech Republic. 554 children of both genders, aged from 4 to 14 years, were included in the current study. Reference values were approximated by Tukey’s Hinges percentiles calculation method. The percentile charts were created using the Lambda-Mu-Sigma (LMS) method.

• MeSH
• dítě MeSH
• fyzikální vyšetření metody   MeSH
• index tělesné hmotnosti MeSH
• lidé MeSH
• síla ruky * fyziologie   MeSH
• svalová síla fyziologie   MeSH
• tělesná hmotnost MeSH
• tělesná výška MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• práce podpořená grantem MeSH

• MeSH
• defekace MeSH
• infekce močového ústrojí terapie   MeSH
• inkontinence moči MeSH
• paraplegie komplikace   ošetřování   MeSH
• poranění míchy rehabilitace   komplikace   MeSH
• urologické chirurgické výkony MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Obory
• nefrologie
• neurologie
• urologie

Fat mass and fat-free mass have become useful clinical indices in determining healthy growth and physical development during critical periods of childhood and adolescence; however, despite a wide range of nutritional surveillance its study is limited by a lack of reference data. The purpose of this study was to establish sex-specific and age-specific standards for fat mass and fat-free mass in a large sample of Croatian children and adolescents. In this cross-sectional study, we collected data from 12,678 participants aged 11 to 18 years old (mean age ± standard deviation (SD): 14.17 ± 2.25 years; height 164.56 ± 11.31 cm; weight: 57.45 ± 13.73 kg; body mass index: 21.24 ± 3.67 kg/m2; 53% girls). Fat mass and fat-free mass were measured three times by bioelectrical impedance. The Lambda, Mu and Sigma methods were used to create percentile charts for fat mass index (FMI) and fat-free mass index (FFMI; fat mass and fat-free mass divided by height2). Sex and age differences were calculated using an analysis of variance (ANOVA) with post hoc comparisons. Boys had lower FMI (from 2.66 to 3.89) and higher FFMI values (from 16.90 to 17.80) in all age groups, compared to girls (for FMI from 2.79 to 5.17 and for FFMI from 14.50 to 14.90, p < 0.001). In boys, FMI slightly declined until the age of 14, after which an increase from the age of 15 to 18 was observed. In girls, FMI gradually increased from the age of 11 to 18 (p < 0.001). In general, FFMI increased by age in boys [F(7,5440) = 52.674, p < 0.001], while girls had more stable FFMI across all age groups [F(7,7222) = 2.728, p = 0.057]. The newly established sex-specific and age-specific reference data could be used for national surveillance and to screen for children and adolescents with high FMI and low FFMI.

• MeSH
• dítě MeSH
• elektrická impedance MeSH
• index tělesné hmotnosti MeSH
• lidé MeSH
• mladiství MeSH
• průřezové studie MeSH
• referenční standardy MeSH
• složení těla * MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Little evidence from observational studies has been provided regarding 'optimal' relative schoolbag load during primary education. Also, no study to date has provided reference-based standards for relative schoolbag weight. Therefore, the main purpose of the study was to establish normative values of relative schoolbag weight in a sample of children. In this cross-sectional study, we recruited 584 primary school students aged 6-14 (meanage±SD = 9.6±2.4 yrs, meanheight±SD = 1.4±0.2 m, meanweight±SD = 37.5±13.3 kg, meanbody-mass index±SD = 17.6±3.1 kg/m2, 44.4% girls) chosen from five schools in the city of Brno. Schoolbag weight and child's body weight were objectively measured by using digital scale. Relative schoolbag weight was calculated by dividing schoolbag weight with child's body weight and the result was expressed in percentage. Lambda, Mu and Sigma (LMS) method was used to create sex- and age-percentile curves. Boys carried slightly heavier schoolbag, compared with girls (mean difference 0.2 kg, p = 0.020). No significant differences between sexes in relative schoolbag weight were observed (p = 0.240). Median values (P50) for boys and girls were similar and the largest observed between ages 6-9 in boys (15-17%) and 6-8 in girls (16-18%). The percentage of children carrying relative schoolbag weight beyond 10% of their body weight was very high, especially between ages 6-10 in boys (85.1-100%) and 6-11 in girls (86.8-95.4%). This study provides first sex- and age- relative schoolbag weight normative values in primary school children. Future studies should use similar methods for generating comparable data.

• MeSH
• dítě MeSH
• index tělesné hmotnosti MeSH
• lidé MeSH
• mladiství MeSH
• pilotní projekty MeSH
• průřezové studie MeSH
• sexuální faktory MeSH
• školy MeSH
• studenti MeSH
• zatížení muskuloskeletálního systému * MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH

Purpose: To determine normative data for gait speed and height-normalized gait speed in community-dwelling older men and women. Materials and Methods: In this cross-sectional study, we recruited 565 men and women aged ≥60 years old. Age was calculated from the date of birth and further classified into four categories: (1) 60-65 years, (2) 66-70 years, (3) 71-75 years and (4) ≥76 years. Gait speed was assessed by a pressure platform (ZEBRIS, Munich, Germany) in meters per second (m/s). Height and weight were objectively measured. Height-normalized gait speed was calculated by dividing gait speed by height. We created the 20th, 40th, 60th and 80th percentile curves for both outcome measures using Cole's Lambda (L), Mu (M) and Sigma (S) method. Results: Mean gait speed and height-normalized gait speed was 1.24 (standard deviation 0.28) and 0.75 (0.17). Significant age-related decline in gait speed for both sexes was observed (p < 0.001). Being a woman (β = - 0.09, p < 0.001), being older (β = - 0.02, p < 0.001) and having higher body mass index values (β = - 0.02, p < 0.001) were significantly associated with slower gait speed. Conclusion: Gait speed significantly declines with age in both older men and women. Providing normative data can be used in screening and monitoring "slow" walkers to prevent from foot pain and higher risk of falls.

• MeSH
• chůze (způsob) fyziologie   MeSH
• index tělesné hmotnosti MeSH
• lidé středního věku MeSH
• lidé MeSH
• průřezové studie MeSH
• referenční standardy MeSH
• rychlost chůze fyziologie   MeSH
• samostatný způsob života MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• sexuální faktory MeSH
• tělesná hmotnost MeSH
• tělesná výška fyziologie   MeSH
• věkové faktory MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Německo MeSH

Cíle: Hledání vztahů rutinně i zatím řídce užívaných biochemických ukazatelů k zátěži resekčním výkonem. Nemocní a metody: Soubor 37 operantů tvorily dva podsoubory podle povahy postižení tlustého střeva vyžadujícího resekci. Mezi malignitami dominovala diagnóza adenokarcinomu tračníku (23 pacienti, prům. BMI 25,59, prům. věk 63,65 roku). Nejčetnějšími benigními onemocněními byly Crohnova nemoc a komplikovaná divertikulámí nemoc tračníku (14 nemocných, prům. BMI 21,91, prům. věk 39,50). Vzorky krve byly odebírány před operací, ihned po ní a v 6:00 hodin 1., 3. a 5. pooperační den. Stanovení ukazatelů bylo provedeno rutinními biochemickými metodami (albumin, CRP, cholinesteráza, haptoglobin, cholesterol), speciálními metodami (SOD, glutation) a ELISA metodami (leptin, IL-2r a IL-8, TNF). Získané údaje byly zpracovány statistickými metodami programů Sigma-Stat, OneWay ANOVA a testem Uneární regrese. Výsledky: Průměrné sérové koncentrace albuminu, leptinu a cholesterolu klesaly pooperačné významně oproti předoperačním hodnotám. Průměrné sérové koncentrace CRP kulminovaly 3. pooperační den, kdy dosahovaly 722 % u benignit a 1814 % u malignit oproti předoperačním hodnotám. Hodnoty u cholinesterázy, glutationu, SOD a haptoglobinu významnější dynamiku v kolemoperačním období nevykazovaly. Sérové koncentrace leptinu korelovaly s BMI, ale sérové koncentrace většiny ukazatelů s BMI ani s věkem operantů významněji nekorelovaly. Závěry: Sérové koncentrace leptinu, albuminu, haptoglobinu a C-reaktivního proteinu vykazují významnou dynamiku v kolemoperačním období. Kolem 5. pooperačního dne se stabilizují a dosahují předoperačních hodnot. Vzájemná korelace jednotlivých sledovaných ukazatelů je minimální.

Aims; An investigation of some relationships of routinely and rarely used biochemical markers to surgical (operating) trauma. Patients and methods: A group of 37 patients was divided to two subgroups according type of disease with need a resection of large bowel for malignant or benign malady. Large hovel adenocarcinoma was dominated in a subgroup of malignancies (23 patients, mean BMI 25.59, mean age 63.65 years) and Crohn's disease and complicated diverticullary disease were the reasons to operate in the second subgroup of benignities (14 patients, mean BMI 21.21, mean age 39.5 year). Blood samples were taken before an operation, postoperatively (immediately) and at 6:00 a.m. the 1st 3rd and 5th postoperative day. The routine methods (albumin, CRP, cholinesterase, haptoglobin, cholesterol), special methods (SOD, glutathion) and ELISA methods (leptin, IL-2r, IL-8, TNF) were used for evaluation markers. The results were estimated by statistic methods Sigma-Stat, One Way x\NOVA and linear regresion test. Results: The mean serum concentrations of albumin, leptin, cholesterol shifted down very clearly compared to preoperative values. The mean serum concentrations shifted up the 3rd day postoperatively to 722% in benignities and to 1814% in malignancies respectively. The values of cholinesterase, glutation, SOD, and haptoglobin didn't show any more serious dynamics perioperatively. The serum leptin concentrations correlated with BMI but other markers serum concentrations didn't correlate with BMI or with age. Conclusions: The serum leptin, albumin, haptoglobin, CRP concentrations demonstrated serious dynamics perioperatively. These concentrations are stabilized and they reach preoperative levels the 5th postoperative day. Each-other markers correlation is minimal.

• MeSH
• biologické markery krev   MeSH
• dospělí MeSH
• finanční podpora výzkumu jako téma MeSH
• index tělesné hmotnosti MeSH
• klinické laboratorní techniky metody   statistika a číselné údaje   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nemoci střev diagnóza   etiologie   chirurgie   MeSH
• pooperační komplikace diagnóza   etiologie   MeSH
• pooperační období MeSH
• senioři MeSH
• tlusté střevo chirurgie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• přehledy MeSH
• srovnávací studie MeSH