Transition
Dotaz
Zobrazit nápovědu
svazky
Scandinavian journal of rheumatology, ISSN 0301-3847 suppl. 64, 1987
62 s. : tab., grafy ; 23 cm
- MeSH
- antiflogistika MeSH
- revmatické nemoci MeSH
- revmatoidní artritida farmakoterapie MeSH
- Publikační typ
- kongresy MeSH
- sborníky MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- revmatologie
- farmakoterapie
Our study demonstrates that nanoplasmonic sensing (NPS) can be utilized for the determination of the phase transition temperature (Tm) of phospholipids. During the phase transition, the lipid bilayer undergoes a conformational change. Therefore, it is presumed that the Tm of phospholipids can be determined by detecting conformational changes in liposomes. The studied lipids included 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), and 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC). Liposomes in gel phase are immobilized onto silicon dioxide sensors and the sensor cell temperature is increased until passing the Tm of the lipid. The results show that, when the system temperature approaches the Tm, a drop of the NPS signal is observed. The breakpoints in the temperatures are 22.5 °C, 41.0 °C, and 55.5 °C for DMPC, DPPC, and DSPC, respectively. These values are very close to the theoretical Tm values, i.e., 24 °C, 41.4 °C, and 55 °C for DMPC, DPPC, and DSPC, respectively. Our studies prove that the NPS methodology is a simple and valuable tool for the determination of the Tm of phospholipids.
BACKGROUND: Transition from child-centered to adult-centered healthcare is a gradual process that addresses the medical, psychological, and educational needs of young people in the management of their autonomy in making decisions about their health and their future clinical assistance. This transfer is challenging across all chronic diseases but can be particularly arduous in rare neurological conditions. AIM: To describe the current practice on the transition process for young patients in centers participating in the European Reference Network for Rare Neurological Diseases (ERN-RND). METHODS: Members of the ERN-RND working group developed a questionnaire considering child-to-adult transition issues and procedures in current clinical practice. The questionnaire included 20 questions and was sent to members of the health care providers (HCPs) participating in the network. RESULTS: Twenty ERN-RND members (75% adult neurologists; 25% pediatricians; 5% nurses or study coordinators) responded to the survey, representing 10 European countries. Transition usually occurs between 16 and 18 years of age, but 55% of pediatric HCPs continue to care for their patients until they reach 40 years of age or older. In 5/20 ERN-RND centers, a standardized procedure managing transition is currently adopted, whereas in the remaining centers, the transition from youth to adult service is usually assisted by pediatricians as part of their clinical practice. CONCLUSIONS: This survey demonstrated significant variations in clinical practice between different centers within the ERN-RND network. It provided valuable data on existing transition programs and highlighted key challenges in managing transitions for patients with rare neurological disorders.
- MeSH
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- nemoci nervového systému * diagnóza terapie MeSH
- poskytování zdravotní péče * MeSH
- průzkumy a dotazníky MeSH
- vzácné nemoci diagnóza terapie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Evropa MeSH
99 s. : il. ; 30 cm
46 stran : tab., grafy, lit.
- Klíčová slova
- péče zdravotní, Slovensko,
- NLK Obory
- veřejné zdravotnictví
- management, organizace a řízení zdravotnictví
- NLK Publikační typ
- publikace WHO
63 stran : tab., grafy, lit.
- Klíčová slova
- péče zdravotní, Švédsko,
- NLK Obory
- veřejné zdravotnictví
- management, organizace a řízení zdravotnictví
- NLK Publikační typ
- publikace WHO
Mitochondria play an important role in the cell aging process. Changes in calcium homeostasis and/or increased reactive oxygen species (ROS) production lead to the opening of mitochondrial permeability transition pore (MPTP), depolarization of the inner mitochondrial membrane, and decrease of ATP production. Our work aimed to monitor age-related changes in the Ca2+ ion effect on MPTP and the ability of isolated rat liver mitochondria to accumulate calcium. The mitochondrial calcium retention capacity (CRC) was found to be significantly affected by the age of rats. Measurement of CRC values of the rat liver mitochondria showed two periods when 3 to 17-week old rats were tested. 3-week and 17-week old rats showed lower CRC values than 7-week old animals. Similar changes were observed while testing calcium-induced swelling of rat liver mitochondria. These findings indicate that the mitochondrial energy production system is more resistant to calcium-induced MPTP opening accompanied by the damaging effect of ROS in adult rats than in young and aged animals.
Alergické ochorenia radíme medzi najčastejšie chronické choroby – vzhľadom na významný nárast prevalencie za posledných 40 rokov. Celosvetovo nimi trpí až 400 miliónov ľudí. Medzi najčastejšie alergické ochorenia patrí alergická nádcha a priedušková astma. V prezentovanej kazuistike je opísaný súvis ochorení, ukázaný prechod alergickej nádchy do závažnejšieho stupňa alergického pochodu – bronchiálnej astmy. Moderné diagnostické postupy prispeli k rýchlemu stanoveniu diagnózy a nasadenie kvalitnej kombinovanej antiastmatickej liečby zase umožnilo rýchlu kontrolu ochorenia.
Allergic disorders belong to the most frequent chronic diseases – due to the significant increase of their prevalence in last 40 years. They affect up to 400 millions of people worldwide. The most prevalent allergic disorders are allergic rhinitis and bronchial asthma. In the presented case report the connection of the two diseases is described as well as the transition of the allergic rhinitis into more severe grade – the bronchial asthma. The use of modern diagnostic procedures contributed to fast diagnosis and a start of quality combined antiasthmatic treatment to a fast control of the disease.
- MeSH
- albuterol analogy a deriváty aplikace a dávkování MeSH
- antiastmatika * terapeutické užití MeSH
- antihistaminika terapeutické užití MeSH
- aplikace inhalační MeSH
- bronchiální astma * diagnóza farmakoterapie MeSH
- budesonid aplikace a dávkování MeSH
- desenzibilizace imunologická metody MeSH
- ethylaminy aplikace a dávkování MeSH
- fixní kombinace léků MeSH
- hormony kůry nadledvin aplikace a dávkování MeSH
- lidé MeSH
- mladý dospělý MeSH
- oxid dusnatý analýza MeSH
- progrese nemoci MeSH
- sezónní alergická rýma * diagnóza farmakoterapie komplikace MeSH
- udržovací chemoterapie MeSH
- Check Tag
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
