• MeSH
• Cells MeSH
• Herpesviridae MeSH
• Humans MeSH
• Virus Replication MeSH
• In Vitro Techniques MeSH
• Check Tag
• Humans MeSH

• MeSH
• Herpesviridae isolation & purification   MeSH
• Rodentia MeSH

• MeSH
• Glycoproteins classification   metabolism   MeSH
• Glycosylation MeSH
• Herpesviridae classification   MeSH
• Viral Envelope Proteins MeSH
• Virus Replication immunology   MeSH
• Simplexvirus genetics   MeSH
• Viral Proteins biosynthesis   genetics   MeSH
• Publication type
• Review MeSH

• MeSH
• Antiviral Agents MeSH
• Drug Combinations MeSH
• Flavones MeSH
• Herpesviridae drug effects   MeSH
• In Vitro Techniques MeSH

• MeSH
• Herpes Simplex immunology   classification   pathogenicity   MeSH
• Herpesviridae immunology   classification   pathogenicity   MeSH

• MeSH
• Autoradiography MeSH
• Cytomegalovirus analysis   isolation & purification   MeSH
• Electrophoresis MeSH
• Herpesviridae analysis   isolation & purification   MeSH
• Mice MeSH
• Peptides analysis   MeSH
• Simplexvirus analysis   isolation & purification   MeSH
• Check Tag
• Mice MeSH
• Publication type
• Comparative Study MeSH

• MeSH
• Cytomegalovirus pathogenicity   MeSH
• Herpesviridae pathogenicity   MeSH
• Laboratory Infection MeSH
• Mice MeSH
• Animals MeSH
• Check Tag
• Mice MeSH
• Animals MeSH
• Publication type
• Comparative Study MeSH

• MeSH
• Fluorescent Antibody Technique MeSH
• Herpesviridae Infections microbiology   MeSH
• Hybrid Cells MeSH
• Simplexvirus MeSH
• Herpesvirus 4, Human MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• infekční lékařství
• mikrobiologie, lékařská mikrobiologie

Herpetické viry patří mezi významné patogeny v imunosuprimované populaci, což vede ke stoupající spotřebě antiherpetik a také ke stoupajícímu problému se vznikem rezistence k těmto lékům. Článek stručně pojednává o nejvýznamnějších zástupcích z antiherpetik, o základních mechanismech vzniku rezistence a u vybraných herpetických virů také o současných znalostech o prevalenci rezistentních kmenů a genetických změnách spojených se vznikem rezistence.

Herpesviruses belong to important pathogens in immunosuppressed population, which lead to increased consumption of antiherpeticsand of course also in increased level of resistant viruses to these therapeutics. This paper review basic informationsabout the most important members of antiherpetics, basic mechanisms resistance to antiherpetics and up to date knowledgeabout resistance prevalence and genomic changes associated to resistance.

• MeSH
• Anti-Retroviral Agents pharmacology   classification   therapeutic use   MeSH
• Cytomegalovirus genetics   pathogenicity   drug effects   MeSH
• Herpes Simplex drug therapy   virology   MeSH
• Herpesviridae classification   pathogenicity   drug effects   MeSH
• Herpesviridae Infections drug therapy   virology   MeSH
• Humans MeSH
• Mutation MeSH
• Drug Resistance, Viral * genetics   drug effects   MeSH
• Herpesvirus 3, Human genetics   drug effects   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH
• Review MeSH