- MeSH
- Diagnostic Techniques and Procedures MeSH
- Diagnosis MeSH
- Cardiology MeSH
- Heart Diseases diagnosis MeSH
- Publication type
- Congress MeSH
Clinics in perinatology, ISSN 0095-5108 vol. 12, no. 1, February 1985
x, 304 s. : il., tab., grafy ; 23 cm
- MeSH
- Diagnostic Techniques and Procedures MeSH
- Diagnosis MeSH
- Infant, Newborn MeSH
- Check Tag
- Infant, Newborn MeSH
- Publication type
- Collected Work MeSH
- Conspectus
- Pediatrie
- NML Fields
- perinatologie a neonatologie
- diagnostika
Najnovším pokrokom v oblasti zobrazenia srdca je neinvazívna elektrokardiograficky synchronizovaná angiografia multidetektorovou špirálovou computerovou tomografiou (MSCT). Z možností MSCT v neinvazívnej kardiológii využívame 2 základné klinické aplikácie: stanovenie kalciového skóre a kontrastnú angiografiu epikardiálnych koronárnych ciev. MSCT koronarografia má potenciál vylúcit alebo potvrdit koronárny postih. Otvára možnost nielen vizualizovat stenózy, ale aj diferencovat morfológiu plátu a stanovit jeho charakter, rozsah a závažnost. Je významným pokrokom v kardiologickej diagnostike a prínosom pre další manažment pacientov. Ako alternatívna metóda selektívnej koronarografie (SKG) má aj výrazný medicínsky a ekonomický dopad, spocívajúci v znížení poctu „zbytocne realizovaných“ negatívnych SKG a tým uvolnením kapacity pre reálne potrebné výkony, ale aj v možnosti realizácie angioplastiky na jedno sedenie pri už vytvorenej predstave o stave koronárnej cirkulácie pomocou MSCT nálezu. Pri súcasnom pocte a kapacite katetrizacných pracovísk na Slovensku je táto potreba viac ako aktuálna.
The most recent contribution in the field of heart imaging is electrocardiographically synchronized angiography executed through Multidetector Spiral Computerized Tomography (MSCT). From the vast area of clinical applications in noninvasive cardiology, we use two basic ones- the setting of calcium levels and mainly the contrasting angiography of epicardial coronary vessels. MSCT coronarography has the potential to eliminate or to confirm coronary damage. It opens up a new possibility not only to visualize stenosis, but also to differentiate morphology of the plate and to set its character, scope and importance. MSCT coronarography brings important progress to cardiological diagnostics and contributes positively to further management of patients as an alternative method of selective coronarography (SKG), MSCT has a significant medical and economic impact consisting mostly of the elimination of "wastingly done" negative SKG’s. This elimination will free the capacity for really necessary procedures. It will also give the possibility of doing a percutaneous transluminal coronary angioplasty in one sitting, based on previously created idea of the state in which the coronary circulation finds itself diagnosed through MSCT. The need for the above described changes is a hot issue due to the present lack of catheterization workplaces in Slovakia.
- MeSH
- Atherosclerosis diagnosis etiology MeSH
- Diagnostic Techniques, Cardiovascular trends utilization MeSH
- Cardiomyopathies diagnosis etiology MeSH
- Coronary Angiography methods utilization MeSH
- Coronary Vessels chemistry pathology MeSH
- Coronary Disease diagnosis etiology MeSH
- Tomography, Spiral Computed methods utilization MeSH
- Calcium chemistry metabolism adverse effects MeSH
OBJECTIVE: To evaluate the clinical and economic impact of adopting noninvasive prenatal testing (NIPT) using circulating cell-free DNA as a first-line screening method for trisomy 21, 18, and 13 in the general pregnancy population. METHODS: A decision-analytical model was developed to assess the impact of adopting NIPT as a primary screening test compared to conventional screening methods. The model takes the Belgium perspective and includes only the direct medical cost of screening, diagnosis, and procedure-related complications. NIPT costs are EUR 260. Clinical outcomes and the cost per trisomy detected were assessed. Sensitivity analysis measured the impact of NIPT false-positive rate (FPR) on modelled results. RESULTS: The cost per trisomy detected was EUR 63,016 for conventional screening versus EUR 66,633 for NIPT, with a difference of EUR 3,617. NIPT reduced unnecessary invasive tests by 94.8%, decreased procedure-related miscarriages by 90.8%, and increased trisomies detected by 29.1%. Increasing the FPR of NIPT (from < 0.01 to 1.0%) increased the average number of invasive procedures required to diagnose a trisomy from 2.2 to 4.5, respectively. CONCLUSION: NIPT first-line screening at a reasonable cost is cost-effective and provides better clinical outcomes. However, modelled results are dependent on the adoption of an NIPT with a low FPR.
- MeSH
- Cost-Benefit Analysis MeSH
- Aneuploidy * MeSH
- Genetic Testing * MeSH
- Humans MeSH
- Decision Support Techniques MeSH
- Noninvasive Prenatal Testing * MeSH
- Uncertainty MeSH
- Pregnancy MeSH
- Check Tag
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
[1st ed.] viii, 392 s. : il.
- MeSH
- Aortic Valve abnormalities surgery MeSH
- Heart Valve Prosthesis Implantation methods utilization MeSH
- Cardiac Surgical Procedures methods utilization MeSH
- Humans MeSH
- Mitral Valve abnormalities surgery MeSH
- Pulmonary Valve abnormalities surgery MeSH
- Heart Valves abnormalities surgery MeSH
- Check Tag
- Humans MeSH
