V odborné literatuře se traduje názor, že vynikající antimikrobní vlastnosti kyseliny peroxooctové byly objeveny teprve v 50. letech 20. století (Greenspan, U. S. Patent, 1950). Američané Freer a Novy však popsali její velmi dobré baktericidní a sporicidní účinky již v roce 1902.
In scientific literature the discovery of the outstanding antimicrobial properties of peracetic acid is attached to Greenspan (U. S. Patent, 1950). Nevertheless Americans Freer and Novy described its very good bactericidal and sporicidal effects as early as 1902.
ECETOC JACC, ISSN 0733-6339 no. 40
146 s. : tab. ; 32 cm
- Conspectus
- Lékařské vědy. Lékařství
- NML Fields
- toxikologie
- environmentální vědy
A comparative study on the efficacyofperacetic acid and sodium hypochlorite in inactivating resistant stages of microorganisms such as Cryp-tosporidium, Giardia and Cl. perfingens was carried out. Furthermore the evaluation of the potential reciprocal correlation among the concentrations of the organisms was performed. The results obtained indicate that, at the same experimental conditions, peracetic acid and sodium hypochlorite have nearly similar reduction power against the resistant stages of Giardia and Cl. perfringens. Both the oxidants are instead less efficientintheabatementof Cryptosporidium oocysts. Findings have also confirmedourpreviousstudiesontheabsenceofassociationbetweenClostridium and the protozoa.
- MeSH
- Sodium Hypochlorite chemistry MeSH
- Clostridium perfringens drug effects MeSH
- Disinfection methods MeSH
- Giardia drug effects MeSH
- Peracetic Acid chemistry MeSH
- Drug Resistance MeSH
- Humans MeSH
- Sewage microbiology MeSH
- Oocysts drug effects MeSH
- Spores drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Evaluation Study MeSH
AIMS: An effective decontamination procedure of personnel wearing personal protective equipment is required by CBRN responders and healthcare workers when dealing with biological warfare agents or natural outbreaks caused by highly contagious pathogens. This study aimed to identify critical factors affecting the efficacy of peracetic acid (PAA)-based disinfectants and products containing either hydrogen peroxide or sodium hypochlorite under the same conditions. METHODS AND RESULTS: The influence of concentration, application (contact) time, erroneous human behaviour, interfering substance, technical assets and weather conditions on disinfection efficacy against Bacillus subtilis spores were assessed in 14 experimental groups. Residual contamination of protective suits was measured to provide responders with readily understandable information (up to 100 colony forming units classified a suit as disinfected). Weather conditions, short application time and erroneous human behaviour substantially affected the effectiveness of PAAs (P < 0·05). Non-PAA-based disinfectants (either liquid or foam) did not reach comparable efficacy (P < 0·001). CONCLUSIONS: Peracetic acid was effective at a concentration of 6400-8200 ppm and an application time of 4 min. SIGNIFICANCE AND IMPACT OF THE STUDY: The study provides operationally relevant data for the use of PAA-based disinfectants in preparedness planning and management of biological incidents and natural outbreaks.
- MeSH
- Decontamination * MeSH
- Disinfection MeSH
- Disinfectants * pharmacology MeSH
- Peracetic Acid * pharmacology MeSH
- Humans MeSH
- Personal Protective Equipment * microbiology MeSH
- Hydrogen Peroxide pharmacology MeSH
- Spores, Bacterial MeSH
- Health Personnel MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
