Celiakia je celoživotná intolerancia lepku, ktorý sa nachádza v základných obilninách a tým aj v množstve bežne konzumovaných potravín. Celiakia je ochorenie, ktoré sa čoraz častejšie manifestuje v subklinickej alebo oligosymptomatickej forme alebo atypickými prejavmi. Problémy zubnej skloviny, pri ochorení celiakiou, sú pomerne časté a postihujú hlavne permanentný chrup. Často sú vo forme zmeny farby - sivobiele, žlté alebo s hnedými škvrnami na zuboch, s chybnou tvorbou skloviny, s drobnými priehlbinkami či kaskádovitým vzhľadom. Tieto poruchy sú symetrické s najčastejším výskytom na rezákoch a molároch.
Celiac disease is a lifelong intolerance to gluten which is found in basic cereals as well as in a number of commonly consumed foods. Celiac disease is a condition which is increasingly manifested in a subclinical or oligosymptomatic form or by atypical symptoms. In patients with celiac disease, tooth enamel problems are relatively common, particularly affecting the permanent dentition. They often present with discoloration - off-white, yellow, or with brown spots on the teeth, defective enamel formation, small depressions, or cascading appearance. These defects are symmetrical and most commonly occur in the incisors and molars. Material and method: The paper presents an analysis of a group of 48 patients investigated during a 10-year period (2011-2020), aged 7-20 years, of whom 17 were men (35.4%) and 31 women (64.6%). Patients with celiac disease were most often diagnosed with dental malocclusion, delayed tooth eruption, enamel defects, unequal tooth size as well as recurrent aphthous stomatitis or fissured tongue. Discussion: Manifestations in the oral cavity are caused, in particular, by insufficient nutrition, primarily lacking the protein component as well as vitamins and trace elements. The changes in teeth are often permanent and cannot be improved without the patient following a gluten-free diet, the only causal treatment for celiac disease. Conclusion: Patients with celiac disease require a multidisciplinary approach, and good patient cooperation is necessary not only with a gastroenterologist, but also with a dentist. The quality of oral health, including teeth and oral mucosa, often significantly limits the overall health of not only those with celiac disease.
Celiac disease (CD) is a disorder that affects both children and adults. Over the few last decades, several new atypical cases have been identified through improved diagnostic tools. On the other hand, the onset of CD at a later age, including atypical CD forms whose clinical picture overlaps with other autoimmune diseases, shows that currently there are several unknown gene mutations, which could be responsible for the disease development. Non-celiac gluten sensitivity (NCGS) is entity included by the ingestion of gluten leading to intestinal, or extraintestinal symptoms that improve once the gluten is removed from the nutrition. In this article relationships between genetically modified rodent animals with previously unknown multiple organ changes and CD, respectively NCGS are reviewed. Relationships between the small bowel histological changes and other organs pathology are discussed. Results of research document that changes have similar genetic background and can develop to serious autoimmune systematic diseases, including small bowel inflammation resembling atypical CD or NCGS. These may have extra-intestinal symptomatology but without a clear explanation of causes and differences in their manifestations. Research on animal models helps to discover links between several disorders associated with gastrointestinal damage. New methods based on individual gene mutations can help in atypical adult CD and NCGS recognitions in the future.
- MeSH
- celiakie * genetika MeSH
- gluteny MeSH
- hlodavci * MeSH
- modely u zvířat MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
OBJECTIVE: The aim of the study was to evaluate the seroprevalence of West Nile virus (WNV) among the variable population of Eastern Slovakia. METHODS: A serologic survey was conducted using 464 serum samples. The basic demographic, epidemiologic and clinical information was obtained for each serum sample at the time of specimen collection. The presence of antibodies against WNV was investigated using a commercial enzyme-linked immunosorbent assay (ELISA). All the ELISA positive samples were further analysed by a neutralization test with WNV and Usutu virus. RESULTS: Three serum samples (0.65%) from the participants (N = 464) were considered positive for antibodies to WNV. A 29-year-old female was repeatedly exposed to mosquito bites working as a shepherdess and participating in many outdoor activities. Two other females (61 and 76 years old) were treated at the Department of Neurology due to monoparesis of the upper extremity, vertigo; both had a significant epidemiological history with frequent tick and mosquito bites and stay in an endemic region. CONCLUSIONS: Although there was no evidence of WNV infection in the Slovak Republic, the epidemiological situation in the neighbouring countries warrants vigilance and appropriate measures, including the introduction of specific diagnostic tools into clinical practice. The constant monitoring of birds and mosquitoes also seems necessary.
- MeSH
- Culicidae MeSH
- ELISA MeSH
- protilátky virové MeSH
- séroepidemiologické studie MeSH
- virus západního Nilu izolace a purifikace MeSH
- západonilská horečka diagnóza epidemiologie MeSH
- zvířata MeSH
- Check Tag
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Slovenská republika MeSH
OBJECTIVE: Celiac disease (CD) is a chronic long-term disease with autoimmune disorder connected to an allergic reaction to the molecule of gluten. CD is manifested in persons who are genetically predisposed. The only therapy for CD is a strong gluten-free (GF) diet. The aim of our study was to follow the adherence to the gluten-free diet in the selected group of parents and caregivers of children with CD, and to compare factors influencing the adherence to GF diet and therefore influencing also clinical symptoms of CD. We compared and examined important food-related activities as well, by using a personal questionnaire in the group of CD children's parents or caregivers. METHODS: We designed a cross-sectional study; 325 parents or caregivers of children with CD were recruited in the sample. CD was confirmed by the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) criteria. The anonymous questionnaires were collected at summer camps within period data 2012-2016 and followed factors which might have an influence on compliance with GF diet, according to parents' opinions. RESULTS: Adherence to GF diet was statistically significantly higher among girls compared to boys. Parents' questionnaires confirmed that younger group of children and children with the family history of CD had statistically higher compliance with GF diet. Parents with higher education confirmed better adherence to GF diet, statistical analyses confirmed higher adherence in mother´s education compared to father's education. Duration of CD, socio-demographic factors of parents - age of parent, gender of parent, and residency were not statistically significant in terms of compliance with the diet. CONCLUSIONS: Our study confirmed important factors influencing adherence to the GF diet, which are connected to the symptoms and consequences of CD. The assessment of parents' opinions and burden on the families of children with celiac disease should be also reflected in the evaluation of patient's status. Important is also the role of parents in order to facilitate and support clinical interventions and prevention of CD.
- MeSH
- adherence pacienta psychologie statistika a číselné údaje MeSH
- bezlepková dieta * psychologie MeSH
- celiakie dietoterapie psychologie MeSH
- dítě MeSH
- gluteny aplikace a dávkování MeSH
- lidé MeSH
- průřezové studie MeSH
- rodiče psychologie MeSH
- rozložení podle pohlaví MeSH
- stupeň vzdělání MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Slovenská republika MeSH
OBJECTIVE: The aim of our study is to evaluate immune response after receiving the primary vaccination against tick-borne encephalitis (TBE), and to establish a link between seropositivity and selected factors in soldiers. METHODS: Blood samples, questionnaires and vaccination records were obtained. TBE antibodies were detected using both ELISA and a neutralization test (NT). We used logistic regression for statistical analysis. RESULTS: Overall, seropositivity (presence of IgG) was detected in 88% of participants. The proportion of seropositive subjects in relation to the number of doses of vaccine was 69% (2 doses) and 91% (3 doses). A statistically significant relationship was found between seropositivity and the number of vaccine doses. No statistical significance was identified in relation to age and sex. There was no statistical significance of seropositivity, depending on the time of the last dose of the vaccine. CONCLUSIONS: TBE immunisation should be targeted at individuals in the most affected locations and those at highest risk of exposure according to lifestyle and occupation.
- MeSH
- dospělí MeSH
- ELISA MeSH
- imunoglobulin G krev MeSH
- klíšťová encefalitida krev imunologie prevence a kontrola MeSH
- lidé středního věku MeSH
- lidé MeSH
- neutralizační testy MeSH
- ozbrojené síly statistika a číselné údaje MeSH
- protilátky virové krev MeSH
- vakcinace * MeSH
- virové vakcíny aplikace a dávkování imunologie MeSH
- viry klíšťové encefalitidy imunologie izolace a purifikace MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- demineralizace zubů MeSH
- DMF Index MeSH
- dospělí MeSH
- Lactobacillus patogenita MeSH
- lidé MeSH
- obličejová bolest diagnóza klasifikace MeSH
- salivace * MeSH
- senioři MeSH
- Streptococcus mutans patogenita MeSH
- xerostomie * MeSH
- ztráta zubů MeSH
- zubní kaz * etnologie MeSH
- zuby - přehledy zdravotního stavu MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- senioři MeSH
- Publikační typ
- pozorovací studie MeSH
