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BACKGROUND: Antimicrobial coatings of central venous catheters (CVC) have the potential to reduce the risk of infectious complications. The aim of this study was to examine the efficacy of a catheter with a non-leaching antimicrobial coating against catheter colonization and bloodstream infections (BSI). METHODS: The study was conducted in two centers using a prospective, randomized, double-blind and controlled design (680 intensive care patients; a protective CVC (Certofix® protect) or a standard CVC (Certofix®). Primary objectives were the rates of catheter colonization and BSI in the two groups. Other baseline demographics, APACHE II score, insertion site, location of CVC placement (ICU or theatre), indwelling time and length of ICU stay were comparable for both groups. RESULTS: While the rate of catheter colonization between the coated and uncoated CVC (17.4% vs. 18.7%, P=0.7477) and the rate of microbiologically confirmed catheter associated infections were similar (1.4% vs. 1.9%, P=0.7521), the coated CVC showed a significantly lower incidence of BSI (2.0% vs. 6.5%, P=0.0081) and a significantly lower mean incidence of BSI per 1000 catheter days (3.2 vs. 8.3, P=0.0356). CONCLUSION: The non-leaching antibacterial coating of the protective catheter was effective in reducing the incidence of BSI but not the rate of catheter colonization. However, the incidence of BSI is a better surrogate marker for the risk of developing clinical signs of infection suggesting that use of the non-leaching protective catheter is effective in this regard. Trial number: ClinicalTrials.gov (ID: NCT00555282), https://clinicaltrials.gov/show/NCT00555282.

MeSH
antibakteriální látky aplikace a dávkování MeSH
centrální žilní katétry * MeSH
dvojitá slepá metoda MeSH
jednotky intenzivní péče MeSH
katetrizace centrálních vén MeSH
katétrové infekce prevence a kontrola MeSH
lidé středního věku MeSH
lidé MeSH
prospektivní studie MeSH
senioři MeSH
sepse prevence a kontrola MeSH
Check Tag
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
randomizované kontrolované studie MeSH

Článek

Zajištění obtížných dýchacích cest u dospělých a dětí

Anesteziologie a intenzivní medicína. 2019 ; 30 (3-4) : 173-186.

ISSN 1214-2158
Medvik
Zdroj

Článek online

Ten years with AKUTNĚ.CZ®

Mefanet journal. 2019 ; 6 (1) : 9-17.

ISSN 1805-9163
Medvik
Zdroj

The 18 October, 2017 marked the 10-year anniversary of the day when, upon entering the domain name akutne.cz, educational content was displayed in the worldwide Internet network for the first time. It is rather unique that, throughout the ten years, this has been a strictly academic activity aimed to unify and modernize the education of acute medicine. Recently, education in medical fields has undergone dynamic changes and a shift to modern teaching methods. The educational and publishing portal of AKUTNĚ.CZ (the AKUTNĚ.CZ Portal) reflects these changes and brings to light the modern forms of education for both under- and postgraduate candidates in Anaesthesiology and Intensive Medicine (AIM). It is a great appreciation and, at the same time, commitment to the future that a large part of more than 150 students of the Faculty of Medicine of Masaryk University who participated in its development have chosen AIM for their further professional grow.