- MeSH
- chybná diagnóza MeSH
- dengue * diagnóza patologie prevence a kontrola terapie MeSH
- hospitalizace MeSH
- lidé MeSH
- medikační omyly MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- Geografické názvy
- Indie MeSH
Extensive research has been conducted on the SARS-CoV-2 virus in association with various infectious diseases to understand the pathophysiology of the infection and potential co-infections. In tropical countries, exposure to local viruses may alter the course of SARS-CoV-2 infection and coinfection. Notably, only a portion of the antibodies produced against SARS-CoV-2 proteins demonstrate neutralizing properties, and the immune response following natural infection tends to be temporary. In contrast, long-lasting IgG antibodies are common after dengue virus infections. In cases where preexisting antibodies from an initial dengue virus infection bind to a different dengue serotype during a subsequent infection, there is a potential for antibody-dependent enhancement (ADE) and the formation of immune complexes associated with disease severity. Both SARS-CoV-2 and dengue infections can result in immunodeficiency. Viral proteins of both viruses interfere with the host's IFN-I signaling. Additionally, a cytokine storm can occur after viral infection, impairing a proper response, and autoantibodies against a wide array of proteins can appear during convalescence. Most of the reported autoantibodies are typically short-lived. Vaccines against both viruses alter the immune response, affecting the course of viral infection and enhancing clearance. A comprehensive analysis of both viral infections and pathogenicity is revisited to prevent infection, severity, and mortality.
- MeSH
- COVID-19 * imunologie virologie MeSH
- dengue * imunologie virologie MeSH
- koinfekce imunologie virologie MeSH
- lidé MeSH
- protilátky virové * imunologie MeSH
- SARS-CoV-2 * imunologie MeSH
- virus dengue * imunologie MeSH
- zvýšená infektivita v přítomnosti protilátek imunologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
INTRODUCTION: This work focuses on the Dengue-viremia ABC (Atangana-Baleanu Caputo) fractional-order differential equations, accounting for both symptomatic and asymptomatic infected cases. Symptomatic cases are characterized by higher viremia levels, whereas asymptomatic cases exhibit lower viremia levels. The fractional-order model highlights memory effects and other advantages over traditional models, offering a more comprehensive representation of dengue dynamics. METHODS: The total population is divided into four compartments: susceptible, asymptomatic infected, symptomatic infected, and recovered. The model incorporates an immune-boosting factor for asymptomatic infected individuals and clinical treatment for symptomatic cases. Positivity and boundedness of the model are validated, and both local and global stability analyses are performed. The novel Adams-Bash numerical scheme is utilized for simulations to rigorously assess the impact of optimal control interventions. RESULTS: The results demonstrate the effectiveness of the proposed control strategies. The reproduction numbers must be reduced based on specific optimal control conditions to effectively mitigate disease outbreaks. Numerical simulations confirm that the optimal control measures can significantly reduce the spread of the disease. DISCUSSION: This research advances the understanding of Dengue-viremia dynamics and provides valuable insights into the application of ABC fractional-order analysis. By incorporating immune-boosting and clinical treatment into the model, the study offers practical guidelines for implementing successful disease control strategies. The findings highlight the potential of using optimal control techniques in public health interventions to manage disease outbreaks more effectively.
- MeSH
- dengue * MeSH
- epidemický výskyt choroby MeSH
- lidé MeSH
- viremie * MeSH
- virus dengue imunologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
V této kazuistice se budeme věnovat případu 14letého chlapce, který byl přivezen zdravotnickou záchrannou službou (ZZS) na dětské oddělení naší nemocnice pro dva dny trvající horečky, dehydrataci a celkové vyčerpání. Kromě horeček se u chlapce za hospitalizace postupně rozvíjely příznaky respiračního infektu, objevily se průjmovité stolice a makulózní exantém s bílým dermografismem. Z anamnézy bylo při příjmu zjištěno, že se chlapec před dvěma dny vrátil z pobytu v tropické oblasti.
In this article we present a case of a fourteen-year-old boy who was transported via ambulance to our Pediatric Ward due to a two-day-lasting fever, dehydration and total exhaustion. Additionally, the patient progressively developed respiratory symptoms, diarrhoea and rash with white dermographism during hospitalization. The medical history revealed that the boy had been visiting a tropical destination two days prior to hospital admission.
- MeSH
- cestovní nemoci * MeSH
- dengue diagnóza přenos virologie MeSH
- diferenciální diagnóza MeSH
- horečka * diagnóza etiologie klasifikace mikrobiologie MeSH
- koinfekce etiologie klasifikace mikrobiologie MeSH
- lidé MeSH
- mladiství MeSH
- průjem diagnóza etiologie mikrobiologie MeSH
- Salmonella enterica klasifikace patogenita MeSH
- tracheitida diagnóza etiologie farmakoterapie mikrobiologie MeSH
- tropické lékařství MeSH
- Check Tag
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- Aedes virologie MeSH
- dengue * diagnóza etiologie komplikace prevence a kontrola MeSH
- endemické nemoci MeSH
- hemoragická horečka dengue mortalita MeSH
- importované infekce MeSH
- klinický obraz nemoci * MeSH
- koinfekce MeSH
- lidé MeSH
- vakcíny proti horečce dengue terapeutické užití MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
INTRODUCTION: This study aims to describe the epidemiological characteristics of imported cases of dengue (DEN), chikungunya (CHIK), and Zika virus (ZIKV) infections in Czech travellers. MATERIALS AND METHODS: This single-centre descriptive study has retrospectively analysed data of patients with laboratory confirmed DEN, CHIK, and ZIKV infections diagnosed at the Department of Infectious, Parasitic and Tropical Diseases of the University Hospital Bulovka in Prague, Czech Republic from 2004 to 2019. RESULTS: The study included a total of 313 patients with DEN, 30 with CHIK, and 19 with ZIKV infections. Most patients travelled as tourists:263 (84.0%), 28 (93.3%), and 17 (89.5%), respectively (p = 0.337). The median duration of stay was 20 (IQR 14-27), 21 (IQR 14-29), and 15 days (IQR 14-43), respectively (p = 0.935). Peaks of imported DEN and ZIKV infections were noted in 2016, and in 2019 in the case of CHIK infection. Most cases of DEN and CHIKV infections were acquired in Southeast Asia:212 (67.7%) and 15 (50%), respectively, while ZIKV infection was most commonly imported from the Caribbean (11; 57,9%). CONCLUSIONS: Arbovirus infections represent an increasingly significant cause of illness in Czech travellers. Comprehensive knowledge of the specific epidemiological profile of these diseases is an essential prerequisite for good travel medicine practice.
- MeSH
- centra terciární péče MeSH
- dengue * epidemiologie MeSH
- horečka chikungunya * epidemiologie MeSH
- infekce virem zika * epidemiologie MeSH
- lidé MeSH
- retrospektivní studie MeSH
- virus chikungunya * MeSH
- virus zika * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
- MeSH
- dengue * diagnóza epidemiologie terapie MeSH
- diferenciální diagnóza MeSH
- dospělí MeSH
- horečka farmakoterapie MeSH
- importované infekce diagnóza epidemiologie terapie MeSH
- lidé MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
