Hyponatremia is a crucial complication of therapy with thiazide diuretics. This study compares the epidemiological and biochemical profiles and hospital course of patients using hydrochlorothiazide (HCTZ), indapamide (INDA), and chlorthalidone (CTD) admitted with thiazide-associated hyponatremia (TAH). Data were obtained retrospectively from the hospital's digital registries. The epidemiological and biochemical parameters between the HCTZ, INDA, and CTD groups were compared. The correlation between dose and biochemical parameters in each group was performed. The thiazide groups without diuretic co-medication were compared (HCTZ vs. INDA), and the correlation between dose and biochemical parameters in each group was examined. A comparison of the HCTZ (n = 135), INDA (n = 125), and CTD (n = 27) groups identified differences in serum potassium (s-K; p = 0.03). The hyponatremia correction rate was slower in the CTD group at 96 h after admission (p < 0.001). After the exclusion of diuretic co-medication, the HCTZ group (n = 64/135) showed a higher prevalence of ARBs, s-K (both p < 0.001), and a lower median (IQR) equipotent dose (12.5 (o) mg vs. 2.5 (1.2) mg), prevalence of ACE-I (p < 0.001), and eGFR (p = 0.03), when compared to the INDA group (n = 109/125). In conclusion, except for s-K, we observed no significant difference in biochemical and epidemiological profiles between HCTZ, INDA, and CTD. After excluding the influence of other diuretics, we observed higher s-K in the HCTZ group compared to the INDA group, potentially explained by the lower equipotent dose of HCTZ. The CTD group showed a statistically significant trend of slower hyponatremia correction.
- MeSH
- Antihypertensive Agents adverse effects MeSH
- Chlorthalidone * adverse effects therapeutic use administration & dosage MeSH
- Diuretics adverse effects MeSH
- Potassium blood MeSH
- Hydrochlorothiazide * adverse effects therapeutic use administration & dosage MeSH
- Hypertension * drug therapy MeSH
- Hyponatremia * chemically induced epidemiology blood MeSH
- Indapamide * adverse effects therapeutic use administration & dosage MeSH
- Sodium Chloride Symporter Inhibitors adverse effects MeSH
- Cohort Studies MeSH
- Middle Aged MeSH
- Humans MeSH
- Retrospective Studies MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- MeSH
- Adrenergic beta-Antagonists administration & dosage classification therapeutic use MeSH
- Erectile Dysfunction drug therapy MeSH
- Drug Combinations MeSH
- Hydrochlorothiazide administration & dosage pharmacology therapeutic use MeSH
- Hypertension * MeSH
- Humans MeSH
- Nebivolol * administration & dosage pharmacology adverse effects therapeutic use MeSH
- Heart Failure * drug therapy MeSH
- Patient Selection MeSH
- Check Tag
- Humans MeSH
- Keywords
- kongesce,
- MeSH
- Acetazolamide administration & dosage therapeutic use MeSH
- Diagnostic Imaging MeSH
- Diuretics * administration & dosage pharmacology therapeutic use MeSH
- Furosemide administration & dosage therapeutic use MeSH
- Sodium-Glucose Transporter 2 Inhibitors administration & dosage therapeutic use MeSH
- Hydrochlorothiazide administration & dosage therapeutic use MeSH
- Hyperemia * diagnosis etiology drug therapy MeSH
- Cardio-Renal Syndrome diagnosis etiology drug therapy MeSH
- Humans MeSH
- Natriuretic Peptides analysis MeSH
- Renal Insufficiency complications MeSH
- Heart Failure * complications MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Na 19. kongrese Medicíny pro praxi v Olomouci - kongresu praktických lékařů vysílaném on-line 22.-23. dubna 2021 zazněla přednáška "Doporučené postupy léčby arteriální hypertenze ve světle pandemie covidu-19 - existuje důvod ke změnám?" věnovaná platným doporučením pro diagnostiku a léčbu arteriální hypertenze. MUDr. Pavel Rutar ve své přednášce vycházel zejména z doporučení vydaných Evropskou kardiologickou společností (ESC) a Evropskou společností pro arteriální hypertenzi (EHC) v roce 2018. V první části přednášky se věnuje některým důležitým faktům obsaženým v těchto doporučených postupech, zejména s ohledem na jejich dopad do každodenní klinické praxe. Druhá část jeho přednášky pak byla věnovaná tématu mnohokráte skloňovanému v posledním roce, tedy případnému vztahu mezi onemocněním covid-19 a antihypertenzní terapií.
- MeSH
- Antihypertensive Agents administration & dosage pharmacology therapeutic use MeSH
- Adrenergic beta-Antagonists pharmacology therapeutic use MeSH
- COVID-19 MeSH
- Drug Combinations MeSH
- Hydrochlorothiazide pharmacology therapeutic use MeSH
- Hypertension * diagnosis drug therapy MeSH
- Indapamide pharmacology therapeutic use MeSH
- Blood Pressure drug effects MeSH
- Humans MeSH
- Blood Pressure Determination methods MeSH
- Practice Guidelines as Topic MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
- MeSH
- Antihypertensive Agents therapeutic use MeSH
- Adrenergic beta-Antagonists therapeutic use MeSH
- Angiotensin II Type 1 Receptor Blockers therapeutic use MeSH
- COVID-19 complications MeSH
- Diuretics therapeutic use MeSH
- Drug Combinations MeSH
- Hydrochlorothiazide therapeutic use MeSH
- Hypertension * diagnosis drug therapy MeSH
- Indapamide therapeutic use MeSH
- Angiotensin-Converting Enzyme Inhibitors therapeutic use MeSH
- Comorbidity MeSH
- Humans MeSH
- Blood Pressure Determination methods MeSH
- Heart Disease Risk Factors MeSH
- Practice Guidelines as Topic MeSH
- Check Tag
- Humans MeSH
- Publication type
- Congress MeSH
- News MeSH
- MeSH
- Amlodipine therapeutic use MeSH
- Drug Combinations MeSH
- Hydrochlorothiazide therapeutic use MeSH
- Hypertension drug therapy MeSH
- Amlodipine, Valsartan Drug Combination * adverse effects therapeutic use MeSH
- Blood Pressure * drug effects MeSH
- Humans MeSH
- Practice Guidelines as Topic MeSH
- Valsartan therapeutic use MeSH
- Treatment Outcome MeSH
- Dose-Response Relationship, Drug MeSH
- Check Tag
- Humans MeSH
- Keywords
- studie EXCITE, Valtricom,
- MeSH
- Amlodipine MeSH
- Drug Combinations MeSH
- Hydrochlorothiazide MeSH
- Hypertension * MeSH
- Clinical Studies as Topic MeSH
- Humans MeSH
- Valsartan MeSH
- Check Tag
- Humans MeSH
- MeSH
- Medication Adherence MeSH
- Amlodipine pharmacology therapeutic use MeSH
- Antihypertensive Agents pharmacology therapeutic use MeSH
- Drug Combinations MeSH
- Hydrochlorothiazide pharmacology therapeutic use MeSH
- Hypertension * drug therapy MeSH
- Humans MeSH
- Valsartan pharmacology therapeutic use MeSH
- Check Tag
- Humans MeSH
- MeSH
- Antihypertensive Agents administration & dosage pharmacology classification MeSH
- Chlorthalidone administration & dosage pharmacology MeSH
- Diabetes Mellitus drug therapy MeSH
- Diuretics * administration & dosage pharmacology classification MeSH
- Hydrochlorothiazide administration & dosage pharmacology MeSH
- Hypertension drug therapy MeSH
- Indapamide administration & dosage pharmacology MeSH
- Cardiovascular Diseases prevention & control MeSH
- Humans MeSH
- Practice Guidelines as Topic MeSH
- Thiazides * administration & dosage pharmacology MeSH
- Check Tag
- Humans MeSH
