- MeSH
- Adrenergic beta-Antagonists administration & dosage adverse effects therapeutic use MeSH
- Bisoprolol * administration & dosage adverse effects therapeutic use MeSH
- Drugs, Generic administration & dosage adverse effects therapeutic use MeSH
- Drug Evaluation methods standards trends MeSH
- Hypertension drug therapy prevention & control MeSH
- Myocardial Ischemia * drug therapy prevention & control MeSH
- Humans MeSH
- Meta-Analysis as Topic MeSH
- Arrhythmias, Cardiac drug therapy prevention & control MeSH
- Heart Failure * drug therapy prevention & control MeSH
- Statistics as Topic MeSH
- Check Tag
- Humans MeSH
- MeSH
- Biological Therapy * economics methods utilization MeSH
- Biotechnology economics methods standards trends MeSH
- Drugs, Generic administration & dosage economics pharmacology therapeutic use MeSH
- Drug Evaluation MeSH
- Immunotherapy * economics ethics methods standards trends utilization MeSH
- Pharmaceutical Preparations * economics MeSH
- Medical Oncology * MeSH
- Humans MeSH
- Drug Approval MeSH
- Research MeSH
- Check Tag
- Humans MeSH
- Publication type
- Newspaper Article MeSH
- Keywords
- levotyroxin,
- MeSH
- Drugs, Generic * administration & dosage pharmacokinetics adverse effects MeSH
- Hypothyroidism * etiology drug therapy blood MeSH
- Iodine administration & dosage urine deficiency MeSH
- Iodide Peroxidase physiology drug effects MeSH
- Pharmaceutical Preparations MeSH
- Drug Interactions MeSH
- Humans MeSH
- Therapeutic Equivalency * MeSH
- Thyrotropin blood MeSH
- Thyroxine * administration & dosage pharmacokinetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
- MeSH
- Economics, Pharmaceutical trends MeSH
- Drugs, Generic * administration & dosage economics therapeutic use supply & distribution MeSH
- Cardiovascular Diseases economics drug therapy prevention & control MeSH
- Humans MeSH
- Drug Costs statistics & numerical data MeSH
- Check Tag
- Humans MeSH
- Publication type
- Newspaper Article MeSH
- Keywords
- šíře terapeutického indexu, léková anamnéza pacienta, generická preskripce,
- MeSH
- Pharmacists MeSH
- Drugs, Generic * administration & dosage economics pharmacology chemistry classification standards therapeutic use supply & distribution MeSH
- Informed Consent MeSH
- Pharmaceutical Preparations MeSH
- Drug Prescriptions * MeSH
- Humans MeSH
- Drug Substitution * economics ethics classification methods standards statistics & numerical data trends utilization MeSH
- Drug Costs MeSH
- Patents as Topic MeSH
- Therapeutic Equivalency MeSH
- Legislation as Topic MeSH
- Legislation, Drug * MeSH
- Check Tag
- Humans MeSH
- MeSH
- Biosimilar Pharmaceuticals * administration & dosage economics therapeutic use toxicity MeSH
- Pharmacokinetics MeSH
- Drugs, Generic * administration & dosage economics therapeutic use toxicity MeSH
- Drug Prescriptions MeSH
- Humans MeSH
- Neoplasms drug therapy MeSH
- Drug Substitution adverse effects MeSH
- Drug Approval methods organization & administration MeSH
- Adverse Drug Reaction Reporting Systems MeSH
- Therapeutic Equivalency MeSH
- Dose-Response Relationship, Drug MeSH
- Check Tag
- Humans MeSH
Anticholinergika jsou látky, které jsou v medicíně široce používány. V urologii jsou lékem první volby v terapii hyperaktivního měchýře. Jejich vysoká účinnost byla prověřena v mnoha klinických studiích. Hlavní nevýhodou této léčby je relativně častý výskyt vedlejších antimuskarinových účinků. Autoři se ve svém článku zaměřují především na mechanizmus vzniku těchto obtěžujících projevů.
Anticholinergic agents are widely used in medicine. In urology, they are the first-choice drugs in the treatment of overactive bladder. Their high efficacy has been proved in many clinical trials. The main drawback of this treatment is the relatively frequent occurrence of antimuscarinic side effects. The article mainly deals with the mechanism of origin of these annoying symptoms.
- Keywords
- antimuskarinika, muskarinové receptory, vedlejší účinky anticholinergik,
- MeSH
- Muscarinic Antagonists * administration & dosage adverse effects therapeutic use MeSH
- Cholinergic Antagonists administration & dosage adverse effects therapeutic use MeSH
- Drugs, Generic administration & dosage adverse effects therapeutic use MeSH
- Urinary Bladder, Overactive * drug therapy MeSH
- Comorbidity MeSH
- Humans MeSH
- Drug-Related Side Effects and Adverse Reactions drug therapy complications MeSH
- Receptors, Muscarinic * classification therapeutic use drug effects MeSH
- Statistics as Topic MeSH
- Urology methods trends MeSH
- Age Factors MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Erektilní dysfunkce (ED) postihuje 54 % českých mužů ve věku nad 35 let. Definujeme ji jako neschopnost dosáhnout a udržet ztopoření dostatečné k realizaci uspokojivého sexuálního styku. ED je často prvním příznakem závažných chorob, nejčastěji kardiovaskulárních. Moderní léčba ED představuje podávání inhibitorů PD E5, tato léčba je bezpečná a účinná i u rizikových nemocných. Druhou linii léčby představují intrakavernózní injekce prostaglandinu E 1. Léčba erektilní dysfunkce zlepšuje párovou satisfakci a kvalitu života postiženého muže.
Czech men (aprox. 54 %) suffer from erectile dysfunction (ED). Erectile dysfunction is defined as an inability to achieve and maintain an erection sufficient for satisfactory sexual intercourse. Erectile dysfunction is the first symptom of seriouse diseases, especially cardio vascular ones. Modern oral therapy by PDE 5 inhibitors is safe, effective and well tolerated. The second line therapy is based on intracavernous injections of prostaglandin E 1. ED therapy leeds to achievement partner’s satisfaction and quality of life of inable man.
- Keywords
- kardiovaskulární morbidita, inhibitory PD E5, intrakavernózní léčba,
- MeSH
- Diabetes Mellitus MeSH
- Erectile Dysfunction * diagnosis etiology therapy MeSH
- Drug Therapy methods utilization MeSH
- Drugs, Generic administration & dosage adverse effects therapeutic use MeSH
- Phosphodiesterase Inhibitors * administration & dosage adverse effects therapeutic use MeSH
- Myocardial Ischemia complications MeSH
- Comorbidity MeSH
- Humans MeSH
- Prostaglandins E * administration & dosage adverse effects therapeutic use MeSH
- Practice Guidelines as Topic MeSH
- Age Factors MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- Case Reports MeSH
- Review MeSH
- MeSH
- Drugs, Generic administration & dosage therapeutic use supply & distribution MeSH
- Catalogs, Drug as Topic MeSH
- Drug Prescriptions * economics MeSH
- Humans MeSH
- Professional Misconduct ethics MeSH
- Universal Health Insurance * economics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Newspaper Article MeSH
