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MeSH: nemoc štěpu proti hostiteli-terapie

29 záznamů v Medvik Filtry

Článek

Quo vadis, hematologie?

Viktorová, Kateřina
Autor Autorita

Remedia. 2022 ; 32 (4) : 398-404.

ISSN 0862-8947
Medvik
Zdroj

MeSH
chronická myeloidní leukemie farmakoterapie patologie MeSH
folikulární lymfom terapie MeSH
hematologie * MeSH
hormony kůry nadledvin škodlivé účinky terapeutické užití MeSH
imunoterapie adoptivní MeSH
inhibitory tyrosinkinasy aplikace a dávkování škodlivé účinky terapeutické užití MeSH
lidé MeSH
nemoc štěpu proti hostiteli terapie MeSH
Check Tag
lidé MeSH
Publikační typ
zprávy MeSH

Článek

Analysis of extracorporeal photopheresis within the frame of the WAA register

Transfusion and apheresis science. 2021 ; 60 (5) : 103172. [pub] 20210527

Transfus Apher Sci
ISSN 1473-0502
Medvik
Zdroj

The aim of the study was to investigate safety and if extracorporeal photopheresis (ECP) may change health criteria (HC) and quality of life (QoL).MATERIAL AND METHOD: 560 patients (33 % women) were treated with ECP for a total of 13,871 procedures during a 17-years period. Mean age was 48 years (±18, range 3-81 years). Self-estimation of QoL was graded: 0 (suicidal) up to 10 (best ever) and HC: 0 (Bed ridden, ICU condition) up to 10 (athletic). Adverse events were analyzed. ANOVA and paired comparisons were performed. RESULTS: Patients were treated due to graft versus host disease (GVHD, n = 317), skin lymphoma (n = 70), solid organ transplants (n = 47), skin diseases (n = 20) and other diseases (n = 106). Adverse events (AEs) were registered in 5.4 % of the first treatments and in 1.2 % of the subsequent procedures. Severe AEs were present in 0.04 % of all procedures. No patient died due to the procedure. Tingling and stitching were the most common AE. For those with GVHD an improvement was noticed within approximately 10 procedures of ECP in the severity stage, QoL (from a mean of 6.1 to 6.8, p < 0.002) and the HC (6.1 -> 6.4, p < 0.014) and improved further with added procedures. CONCLUSION: Photopheresis is an established therapy with few side effects. The present study of soft variables indicate that GVHD shows benefits upon ECP within approximately 10 procedures in regard to the severity of mainly skin GVHD, and lower baseline levels of HC and QoL.

MeSH
chronická nemoc MeSH
dítě MeSH
dospělí MeSH
fotoferéza metody MeSH
hemodynamika MeSH
kvalita života MeSH
lidé středního věku MeSH
lidé MeSH
lymfom psychologie terapie MeSH
mladiství MeSH
mladý dospělý MeSH
nádory kůže psychologie terapie MeSH
nemoc štěpu proti hostiteli psychologie terapie MeSH
předškolní dítě MeSH
registrace MeSH
retrospektivní studie MeSH
senioři nad 80 let MeSH
senioři MeSH
Check Tag
dítě MeSH
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mladiství MeSH
mladý dospělý MeSH
mužské pohlaví MeSH
předškolní dítě MeSH
senioři nad 80 let MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH

Článek

Comparison of the immunomodulatory effect of single MSC batches versus pooled MSC products

Cell and tissue banking. 2020 ; 21 (1) : 119-129. [pub] 20191220

Cell Tissue Bank
ISSN 1573-6814
Medvik
Zdroj

Severe corticosteroid-refractory graft-versus-host-disease (GVHD) is a major non-relapse cause of mortality and morbidity after an allogeneic hematopoietic stem cell transplantation (allo-HSCT). One of the most promising treatment options is using advanced therapy medicinal products based on mesenchymal stem cells (MSCs) immunomodulation ability. The protocols of MSC application differ in many parameters including a source of MSC, a dose, a number of doses or way of preparation of the medicinal product. The process is limited by the need for laborious and expensive manufacturing processes fraught with batch-to-batch variability. In our study, we compared the immunomodulatory effects of different MSC batches versus pooled MSC, specifically the influence on lymphocyte proliferation, the metabolic activity, and the expression of activation markers on T cells. Our goal was to determine whether the effect depends on donor-to-donor heterogeneity and if pooling of MSCs could increase their immunomodulatory ability. All tested batches showed an immunomodulatory effect, with no significant differences between the groups. Our study suggests that immunosuppressive potential is comparable in single batches and pooled products, and the use of products got from individual donors is suitable to treat corticosteroid-refractory GVHD.

MeSH
aktivace lymfocytů MeSH
dárci tkání MeSH
imunomodulace * MeSH
kokultivační techniky MeSH
kultivované buňky MeSH
lidé MeSH
mezenchymální kmenové buňky cytologie imunologie MeSH
nemoc štěpu proti hostiteli etiologie imunologie terapie MeSH
proliferace buněk MeSH
separace buněk MeSH
T-lymfocyty cytologie imunologie MeSH
transplantace hematopoetických kmenových buněk škodlivé účinky MeSH
transplantace mezenchymálních kmenových buněk MeSH
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lidé MeSH
Publikační typ
časopisecké články MeSH
srovnávací studie MeSH

Kapitola

Akútna reakcia štepu proti hostitelovi - použitie extrakorporálnej fotoferézy a ruxolitinibu

Sopko, Ladislav
Autor Autorita Klinika hematologie a transfúziológie LF UK, SZU a UN, Bratislava

Hematologie a hematoonkologie v kazuistikách. 2020 ; () : 229-232.

ISBN 978-80-7345-681-8
Medvik
Zdroj

Klíčová slova
ruxolitinib,
MeSH
akutní myeloidní leukemie komplikace terapie MeSH
fotoferéza metody škodlivé účinky MeSH
homologní transplantace škodlivé účinky MeSH
inhibitory Janus kinas aplikace a dávkování škodlivé účinky MeSH
kojenec MeSH
kombinovaná terapie metody škodlivé účinky MeSH
kontraindikace léčebného výkonu MeSH
lidé středního věku MeSH
methylprednisolon aplikace a dávkování MeSH
nemoc štěpu proti hostiteli * diagnóza farmakoterapie patologie terapie MeSH
průjem etiologie MeSH
recidiva MeSH
transplantace kostní dřeně škodlivé účinky MeSH
Check Tag
kojenec MeSH
lidé středního věku MeSH
mužské pohlaví MeSH
Publikační typ
kazuistiky MeSH

Kapitola

Vírusové komplikácie po alogénnej transplantácii krvotvornými kmeňovými bunkami u pacienta s Hodgkinovým lymfómom

Ladická, Miriam
Autor Autorita Klinika onkohematológie, Národný onkologický ústav, LF UK, Bratislava

Hematologie a hematoonkologie v kazuistikách. 2020 ; () : 233-238.

ISBN 978-80-7345-681-8
Medvik
Zdroj

Článek

NFKB1 gene single-nucleotide polymorphisms: implications for graft-versus-host disease in allogeneic hematopoietic stem cell transplantation

Annals of hematology. 2020 ; 99 (3) : 609-618. [pub] 20200130

Ann Hematol
ISSN 1432-0584
Medvik
Zdroj

Graft-versus-host disease (GVHD) represents a significant cause of mortality after allogeneic hematopoietic stem cell transplantation (HSCT). NF-kB system is a master regulator of innate immunity responses. It controls the expression of various cytokines and chemokines many of which are involved in GVHD pathogenesis. Chemo(radio) therapy administered during conditioning induces DNA damage and activates DNA damage response (DDR) signaling resulting in irreversible cell cycle arrest - cellular senescence which has been described to be associated with robust pro-inflammatory secretion mostly controlled by NF-kB. The NFKB1 gene encodes the DNA-binding subunit of the NF-kB complex. Using the candidate gene approach, we analyzed possible association of two single-nucleotide polymorphisms (SNPs) rs3774937 C/T and rs3774959 A/G of the NFKB1 gene with GVHD and transplant-related mortality (TRM) occurrence in 109 recipients allografted from HLA-identical donor. Both SNPs in recipients were found to be strongly associated with acute GVHD. Nevertheless, no significant association with chronic GVHD and TRM was found. Presented pilot results contribute to pre-clinical observations and suggest that NF-kB may be an important regulator of HSCT-related inflammatory reactions such as acute GVHD. Novel pathogenic mechanisms of GVHD may arise from perspectives of DDR and cellular senescence where NF-kB plays an essential role.