OBJECTIVES: The prevalence of restless legs syndrome (RLS) in functional movement disorders (FMD) is not known. Patients with FMD often present with multiple motor and sensory symptoms. Some of these symptoms might be due to comorbid RLS. Therefore, our objective was to evaluate possible association between FMD and RLS. DESIGN: Case-control study. SETTING: Movement Disorders Center, 1st Faculty of Medicine and General University Hospital in Prague, Czech Republic. PARTICIPANTS: 96 consecutive patients with clinically established FMD (80 females, mean age (SD) 45.0 (13) years), and 76 matched controls. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome measure was prevalence of RLS based on updated International RLS Study Group criteria. Secondary outcome measures included prevalence of periodic limb movements (PLM) using actigraphy; pain, motor and sensory symptoms in lower limbs; organic comorbidities and medication affecting RLS. RESULTS: RLS criteria were fulfilled in 43.8% of patients (95% CI 34 to 54) and in 7.9% of controls (95% CI 3 to 17, p<0.00001). Both RLS and PLM indices (PLMi) ≥22.5/hour were found in 21.2% of patients with FMD and 2.6% of controls. Patients with FMD with RLS had a higher mean PLMi (p<0.001) and a higher proportion of PLMi ≥22.5/hour (p<0.01) than RLS-negative patients. Patients with RLS had higher prevalence of pain and sensory symptoms in lower limbs, no difference was found in medication and prevalence of organic comorbidities in patients with FMD with and without RLS. CONCLUSIONS: We found an increased prevalence of RLS in patients with FMD. Clinical diagnosis of RLS was supported by actigraphic measurement of clinically relevant PLM in a significant proportion of patients with FMD. Although functional motor and sensory symptoms may mimic RLS, RLS may be unrecognised in patients with FMD. This finding may have clinical implications in management of FMD, and it raises the possibility of common pathophysiological mechanisms of FMD and RLS/PLM.
- MeSH
- dospělí MeSH
- dystonie patofyziologie MeSH
- konverzní poruchy epidemiologie patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- myoklonus patofyziologie MeSH
- neurologické poruchy chůze patofyziologie MeSH
- pohybové poruchy epidemiologie patofyziologie MeSH
- poruchy hybnosti oka patofyziologie MeSH
- poruchy řeči patofyziologie MeSH
- prevalence MeSH
- studie případů a kontrol MeSH
- svalová slabost patofyziologie MeSH
- syndrom neklidných nohou epidemiologie MeSH
- tremor patofyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Intramural MeSH
- Geografické názvy
- Česká republika MeSH
The main purpose of this retrospective analysis was to evaluate the incidence and lateralization value of rhythmic ictal nonclonic hand (RINCH) motions in patients with temporal lobe epilepsy (TLE), who were classified as Engel I at least 2 years after epilepsy surgery. We analyzed the distribution of ictal activity at the time of RINCH appearance in patients in whom RINCH motions were present during invasive EEG monitoring. A group of 120 patients was included in this study. In total, we reviewed 491 seizures: 277 seizures in patients with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (TLE-HS group) and 214 in TLE caused by other lesions (TLE-OTH group). We analyzed 29 patients (79 of the seizures) during invasive EEG monitoring. Fisher's exact test and binomial test were used for the statistical analysis. RINCH motions were observed in 24 out of 120 patients (20%) and in 48 out of 491 seizures (9.8%). There was no significant difference between the occurrence of RINCH motions in patients with TLE-HS and in patients with TLE-OTH, or between gender, right/left-sided TLE, and language dominant/nondominant TLE. RINCH motions were contralateral to the seizure onset in 83.3% of patients and 91.7% of seizures (p=0.0015; p<0.001, respectively). There were no differences in the lateralizing value of RINCH motions in patients with TLE-HS or TLE-OTH. We analyzed RINCH motions in 5 patients/7 seizures during invasive EEG. In all 7 seizures with RINCH motions, we observed the widespread activation of the temporal lobe (mesial and lateral, opercular and polar regions) contralateral to the side of RINCH motions. In all 7 seizures, we observed that at the time of RINCH motion onset, at least 1 explored region of the frontal lobe was affected by the ictal activity. In 3 seizures, we observed time-locked epileptic activation associated with the appearance of RINCH motions, i.e., in the orbitofrontal cortex in 2 seizures and in both the orbitofrontal cortex and anterior cingulate gyrus in 1 seizure. RINCH motions are a relatively frequent ictal sign in patients with TLE. They have a high lateralizing value in these patients, occurring contralateral to the ictal onset. RINCH motions usually occur after the spread of ictal activity beyond the temporal lobe, and their appearance is usually associated with the presence of ictal activity in various regions of the contralateral frontal lobe, mainly the orbitofrontal cortex and anterior cingulate gyrus. This is the first study analysing this phenomenon during invasive EEG recording.
- MeSH
- dítě MeSH
- dospělí MeSH
- elektroencefalografie metody MeSH
- epilepsie temporálního laloku komplikace patofyziologie chirurgie MeSH
- funkční lateralita fyziologie MeSH
- incidence MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mozek patologie MeSH
- nádory mozku komplikace patologie MeSH
- pohybové poruchy epidemiologie etiologie patofyziologie MeSH
- retrospektivní studie MeSH
- ruka patofyziologie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- MeSH
- dítě MeSH
- hodnocení léčiv statistika a číselné údaje MeSH
- klinické zkoušky jako téma statistika a číselné údaje MeSH
- kofein terapeutické užití MeSH
- kognitivní poruchy epidemiologie MeSH
- lidé MeSH
- nemoci nedonošenců farmakoterapie prevence a kontrola MeSH
- neuroprotektivní látky terapeutické užití MeSH
- novorozenec nedonošený MeSH
- novorozenec MeSH
- pohybové poruchy epidemiologie MeSH
- předškolní dítě MeSH
- výsledek terapie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- Klíčová slova
- centrální koordinační porucha, posturální aktivita, posturální odchylka, asymetrie, hyperabdukce, anteverze, fyzioterapie, Vojtova metoda, handling, Bobathova technika,
- MeSH
- časná diagnóza MeSH
- financování organizované MeSH
- fyzioterapie (techniky) MeSH
- kineziologie aplikovaná metody MeSH
- kojenec MeSH
- lidé MeSH
- longitudinální studie MeSH
- novorozenec s nízkou porodní hmotností MeSH
- novorozenec s velmi nízkou porodní hmotností MeSH
- pohybové poruchy diagnóza epidemiologie terapie MeSH
- postura těla fyziologie MeSH
- reflexní terapie MeSH
- růstová retardace plodu MeSH
- statistika jako téma MeSH
- věkové faktory MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
INTRODUCTION: Studies of brain morphology suggest a link between movement sequencing ability and basal ganglia dysfunction. Unfortunately, relevant studies have provided inconsistent data, which may be the result of differences in the methods of brain morphology assessment, statistical analysis or heterogeneity of the populations studied. AIM: To test the hypothesis of a link between the dysfunction of movement sequencing and basal ganglia morphology in a homogenous sample of first-episode schizophrenia patients. METHOD: Thirty-seven first-episode schizophrenia patients underwent an assessment of movement sequencing abilities using the NES scale and basal ganglia morphology from MR images. The data were compared with a group of 19 age- and sex-matched healthy controls. RESULTS: The group of first-episode patients had a higher concentration of gray matter than healthy controls in the putamen and pallidum in both hemispheres. Patients with abnormal sequencing of movements had lower gray matter concentration than patients without such abnormalities in the left putamen, and no differences were found between the symptomatic group and healthy controls. SUMMARY AND CONCLUSION: Our study suggests the involvement of the left putamen in the movement sequencing abnormalities in schizophrenia. Because of the potential confounding effect of medication, the lack of support from external evidence and the low power to perform the whole-brain analysis the results should be considered as preliminary. Further studies, especially with antipsychotic-naive first-episode schizophrenia patients are needed to solve these issues.
- MeSH
- akutní nemoc MeSH
- bazální ganglia anatomie a histologie patologie MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- mladý dospělý MeSH
- pohybové poruchy diagnóza epidemiologie MeSH
- schizofrenie diagnóza epidemiologie MeSH
- stupeň závažnosti nemoci MeSH
- Check Tag
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- práce podpořená grantem MeSH
Závěrečná zpráva o řešení grantu Interní grantové agentury MZ ČR
Přeruš. str. : il., tab. ; 30 cm
Incidence of the locomotor system diseases and painful conditions of the backbone in school age children. Study of risk factors supposedly accounting for poor posture in children (age, overweight, low physical activities, positive history in family, long-term disease).
Výskyt onemocnění pohybového aparátu a bolestivých stavů páteře u dětí školního věku. Výzkum předpokládaných rizikových faktorů vadného držení těla u dětí (věk, nadváha, nízká pohybová aktivita, pozitivní rodinná anamnéza, dlouhodobé onemocnění dítěte).
- MeSH
- dítě MeSH
- muskuloskeletální systém - fyziologické jevy genetika imunologie účinky léků MeSH
- pohybové poruchy diagnóza epidemiologie prevence a kontrola MeSH
- postura těla MeSH
- prevalence MeSH
- rizikové faktory MeSH
- vývoj člověka MeSH
- Check Tag
- dítě MeSH
- Konspekt
- Pediatrie
- NLK Obory
- pediatrie
- ortopedie
- zdravotní výchova
- NLK Publikační typ
- závěrečné zprávy o řešení grantu IGA MZ ČR
- MeSH
- hypertenze epidemiologie MeSH
- kardiovaskulární nemoci epidemiologie MeSH
- lidé MeSH
- morbidita trendy MeSH
- nemoci endokrinního systému epidemiologie MeSH
- pohybové poruchy epidemiologie MeSH
- senioři statistika a číselné údaje trendy MeSH
- Check Tag
- lidé MeSH
- senioři statistika a číselné údaje trendy MeSH
