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First published xviii, 174 s.
INTRODUCTION: Numerous variations are characteristic for hand anatomy. Although a lot of work has been done in the field, a detailed description of the branches of the radial artery is still missing. The aim of this study is to determine the incidence and diameter of the accessory artery, which can be found running on the dorsal surface of the interosseus dorsalis primus muscle, to deliver the detailed description of this arterial variation and based on that to suggest a systematic name of the artery which would be in line with Terminologia Anatomica. METHODS: We used 133 complete donor bodies and 237 cadaverous hands in our study, giving us a total sample size of 503 samples. When possible, we determined the age of the donors which was between 62 and 90 years. We performed detailed anatomical dissection to determine the individual branching. We also measured the diameter of selected arteries. When relevant we performed statistical comparisons. To do that we first applied Shapiro-Wilk test to determine the normality of distribution and after that we used Mann-Whitney U test and One-way ANOVA. RESULTS: The variation of interest was found in 11.93% of cases. Based on the anatomical differences we determined four types of branching, type 1-3 forming the anastomosis with superficial palmar arch (being considered as positive findings) and type 4 which did not form this anastomosis (thus considered to be a negative finding). DISCUSSION: We successfully determined the incidence of this arterial variation on a sufficient sample size. We also described the anatomy of this branching in detail and were able to determine four types of this branching. After careful consideration of these findings we proposed the new name for this artery and suggest to use the name superficial dorsal branch of radial artery. This could contribute to a better understanding of this branching and potential use in clinical practice.
- MeSH
- arteria radialis anatomie a histologie MeSH
- charakteristické znaky pohlaví MeSH
- disekce metody MeSH
- lidé středního věku MeSH
- lidé MeSH
- mrtvola MeSH
- ruka anatomie a histologie krevní zásobení MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Understanding the architecture and function of RNA molecules requires methods for comparing and analyzing their tertiary and quaternary structures. While structural superposition of short RNAs is achievable in a reasonable time, large structures represent much bigger challenge. Therefore, we have developed a fast and accurate algorithm for RNA pairwise structure superposition called SETTER and implemented it in the SETTER web server. However, though biological relationships can be inferred by a pairwise structure alignment, key features preserved by evolution can be identified only from a multiple structure alignment. Thus, we extended the SETTER algorithm to the alignment of multiple RNA structures and developed the MultiSETTER algorithm. RESULTS: In this paper, we present the updated version of the SETTER web server that implements a user friendly interface to the MultiSETTER algorithm. The server accepts RNA structures either as the list of PDB IDs or as user-defined PDB files. After the superposition is computed, structures are visualized in 3D and several reports and statistics are generated. CONCLUSION: To the best of our knowledge, the MultiSETTER web server is the first publicly available tool for a multiple RNA structure alignment. The MultiSETTER server offers the visual inspection of an alignment in 3D space which may reveal structural and functional relationships not captured by other multiple alignment methods based either on a sequence or on secondary structure motifs.
Objectives: A significant portion of care related to cardiorespiratory diseases is provided at home, usually but not exclusively, after the discharge of a patient from hospital. It is the purpose of the present study to present the technical means which we have developed, in order to support the adaptation of the continuity of care of cardiorespiratory diseases at home. Methods: We have developed an integrated system that includes: first, a prototype laptop-based portable monitoring system that comprises low-cost commercially available components, which enable the periodical or continuous monitoring of vital signs at home; second, software supporting medical decision-making related to tachycardia and ventricular fibrillation, as well as fuzzy-rules-based software supporting home-ventilation optimization; third, a typical continuity of care record (CCR) adapted to support also the creation of a homecare plan; and finally, a prototype ontology, based upon the HL7 clinical document architecture (CDA), serving as basis for the development of semantically annotated web services that allow for the exchange and retrieval of homecare information. Results: The flexible design and the adaptable data-exchange mechanism of the developed system result in a useful and standard-compliant tool, for cardiorespiratory disease-related homecare. Conclusions: The ongoing laboratory testing of the system shows that it is able to contribute to an effective and low-cost package solution, supporting patient supervision and treatment. Furthermore, semantic web technologies prove to be the perfect solution for both the conceptualization of a continuity of care data exchange procedure and for the integration of the structured medical data.
- MeSH
- informační systémy normy MeSH
- internet MeSH
- kardiovaskulární nemoci MeSH
- kontinuita péče o pacienty MeSH
- lidé MeSH
- sémantika MeSH
- služby domácí péče MeSH
- systémová integrace MeSH
- telemetrie metody přístrojové vybavení MeSH
- ukládání a vyhledávání informací metody MeSH
- zajištění kvality zdravotní péče metody MeSH
- Check Tag
- lidé MeSH
E-photosynthesis framework is a web-based platform for modeling and analysis of photosynthetic processes. Compared to its earlier version, the present platform employs advanced software methods and technologies to support an effective implementation of vastly diverse kinetic models of photosynthesis. We report on the first phase implementation of the tool new version and demonstrate the functionalities of model visualization, presentation of model components, rate constants, initial conditions and of model annotation. The demonstration also includes export of a model to the Systems Biology Markup Language format and remote numerical simulation of the model.
Moderní technologie umožňují mimo jiné i zpestření výuky, učinit ji inteaktivnější. Jako důkaz se nabízí e-learning, který nezastoupí v plném rozsahu osobnost erudovaného vyučujícího, ale lze ji považovat za nejefektivnější z alternativních vyučovacích metod. Výuka první pomoci je neustále velkým úskalím. Předpokládá se, že laickou první pomoc by měl umět každý, pravdou ovšem zůstává, že tomu tak ve skutečnosti není. Mnohdy se setkáváme s texty popisujícími postup při poskytování první pomoci, často však schází názornost, která by pomohla lepšímu zapomatování a upevnění nabytých poznatků. Výše uvedené skutečnosti nás dovedly k vytvoření internetových stránek o poskytování laické první pomoci – www.prvni-pomoc.net. Tyto webové stránky jsou určeny široké veřejnosti, domníváme se, že podpoří v zájmu o tuto problematiku i děti a dospívající (virtuální záchranáři, kteří tvoří průvodce-odborníky).
Web sites available at www.prvni-pomoc.net were established to support laypeople training in the first aid, mainly in urgent resuscitation. Modern technologies enable to manage the courses in a more interactive way. It is supposed that everyone should have basic knowledge about the first aid procedures, but the real situation is different. There are numerous text documents describing the first aid techniques, but they are not clear enough. This was the main reason why our web sites were developed.
- MeSH
- internet využití MeSH
- počítačem řízená výuka * využití MeSH
- první pomoc * MeSH
- terapie náhlých příhod MeSH
- zdravotní výchova * metody trendy MeSH
- Geografické názvy
- Česká republika MeSH
Základní a střední školy mají legislativně uložené povinnosti v oblasti poskytování první pomoci svým pracovníkům i žákům a také v zajištění výuky žáků v této oblasti. Co však chybí, to jsou standardy, které by jednoznačně definovaly obsah i rozsah vzdělávání pracovníků škol i výuky žáků v první pomoci a to v návaznosti na současný systém fungování přednemocniční neodkladné péče. V příspěvku představujeme výstupy vzdělávacích projektů, které byly zaměřeny na komplexní zpracování tématu první pomoci pro potřeby škol. Představujeme návrh koncepce vzdělávání pracovníků škol a školských zařízení a také vhodnou metodiku, kterou jsme za tímto účelem vypracovali a kterou jsme v rámci projektů na cílové skupině ověřili.
Primary and secondary schools have legislatively given duties in the area of giving first aid to their employees and students and also in ensuring the education of their students in this sphere. However, there is a lack of standards which would unambiguously define the content and extent of the employees and students education in first aid in context of the current system of prehospital emergency care. We present outputs of educational projects which have been focused on the complex treating of first aid for school needs in this article. We also introduce a draft concept of training for school employees and educational institutions and of proper methodology which we have prepared for this purpose and which we have tested on a target group within the project.
Caver Web 1.0 is a web server for comprehensive analysis of protein tunnels and channels, and study of the ligands' transport through these transport pathways. Caver Web is the first interactive tool allowing both the analyses within a single graphical user interface. The server is built on top of the abundantly used tunnel detection tool Caver 3.02 and CaverDock 1.0 enabling the study of the ligand transport. The program is easy-to-use as the only required inputs are a protein structure for a tunnel identification and a list of ligands for the transport analysis. The automated guidance procedures assist the users to set up the calculation in a way to obtain biologically relevant results. The identified tunnels, their properties, energy profiles and trajectories for ligands' passages can be calculated and visualized. The tool is very fast (2-20 min per job) and is applicable even for virtual screening purposes. Its simple setup and comprehensive graphical user interface make the tool accessible for a broad scientific community. The server is freely available at https://loschmidt.chemi.muni.cz/caverweb.
- MeSH
- algoritmy * MeSH
- benchmarking MeSH
- interakční proteinové domény a motivy MeSH
- internet MeSH
- kvarterní struktura proteinů MeSH
- lidé MeSH
- ligandy MeSH
- sekvence aminokyselin MeSH
- simulace molekulového dockingu MeSH
- terciární struktura proteinů MeSH
- transportní proteiny chemie metabolismus MeSH
- uživatelské rozhraní počítače * MeSH
- vazba proteinů MeSH
- vazebná místa MeSH
- výpočetní biologie metody MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- MeSH
- farmaceuti MeSH
- internet MeSH
- lidé MeSH
- poradenství metody organizace a řízení MeSH
- první pomoc * metody MeSH
- zdravotní výchova metody MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- novinové články MeSH
- Klíčová slova
- iPhone, iPad, medicínské aplikace,
- MeSH
- internet MeSH
- lidé MeSH
- mobilní telefon využití MeSH
- počítače využití MeSH
- počítačem řízená výuka metody MeSH
- první pomoc MeSH
- telemedicína * trendy MeSH
- urgentní zdravotnické služby metody MeSH
- Check Tag
- lidé MeSH
